Reflections on Biochemistry

Biographical Introduction: Severo Ochoa and the Development of BiochemistryI. Energy Metabolism, Photosynthesis, Fermentation The Role of Lactic Acid in the Development of Biochemistry Origins of the Concept of Oxidative Phosphorylation: Retrospectives and Perspectives Reflections on the Evolutionary Transition from Prokaryotes to Eukaryotes A Pathway from Psychiatry to Cancer Bioenergetics: Past, Present and Future Enzymes Revisited Unraveling the Pentose Phosphate Pathway Reducing Power and the Regulation of Photosynthesis Studies on High-Energy Phosphate Bonds: From Biosynthetic to Mechanochemical Reactions Glutamate Fermentation and the Discovery of B12 Coenzymes Trailing the Propionic Acid Bacteria Biosynthesis of Cell Components from Acetate Lessons in Learning The Impact of the ATP-Generating SystemsII. Lipids, Saccharides, Cell Walls On the Evolution of a Biosynthetic Pathway My Expeditions into Sulfur Biochemistry The Clostridium kluyveri-Acetyl-CoA Epoch Biotin Unmasked The Seven Veils of Dipicolinic Acid Enzymic Mechanisms Involved in the Synthesis of Yeast Cell WallIII. Regulation The Pasteur Effect in the Allosteric Era Comparative Aspects of Hormonal Regulation of Adipose Tissue Lipolysis Reflections on the Relevance of Biochemistry for the Understanding of Living Systems Formation and Cleavage of C-N Bonds in Arginine Biosynthesis and Urea Formation Molecular EcologyIV. Nucleic Acids and the Genetic Code For the Love of Enzymes From Enzyme Chemistry to Genetic Manipulation The Search for the Structural Relationship between Gene and Enzyme Synthesis in the Study of Nucleic Acids A Phage in New York Bacteriophage ø29V. Protein Biosynthesis Protein Synthesis: Early Waves and Recent Ripples Ten Years in Protein Synthesis Bacteriophages, Colicins and Ribosomes: Some Reflections on my Research Career Ribosomes: Structure, Function and Evolution Thoughts on Polypeptide Chain Elongation Twenty-Five Years of Research on Inhibitors of Protein Synthesis: Prospects for Future Developments in the SubjectVI. Cell Biology and Neurobiology A Biochemist Looks at the Nervous System Brain Damage and Perinatal Biochemistry My Interrupted Association with Potassium A Personal Account of My Research on Collagen and FibrosisVII. Science in the Time of Ochoa Reminiscences of Severo Ochoa from Our Oxford Days Highlights of a Friendship Discovery Made Easy Comments on the Productivity of Scientists Prebiological Chemistry and the Origin of Life: A Personal Account My Homage to Severo OchoaName IndexSubject Index