Abbreviations

5-HT1A serotonin 1A receptor ACh acetylcholine AChE acetylcholinesterase AcOH acetic acid ACPC 1-aminocyclopentanecarboxylic acid AD Alzheimer's disease ADC antibody drug conjugate ADM s-adenosyl-L-methionine AI artificial intelligence ALARA as low as reasonably achievable AMDP aminomethylenediphosphonate AMT a-Methyl-L-tryptophan ATP adenosine triphosphate ATTR amyloid transthyretin BACE beta-secretase BAT brown adipose tissue BBB blood-brain barrier Bmax maximum concentration of target binding sites BOx benzoxazole BP binding potential BP British Pharmacopeia Bq becquerel BTA aryl-benzothiazole BZD benzodiazepine CAD coronary artery disease cAMP cyclic adenosine monophosphate CBF cerebral blood flow CBS compton backscattered [11C]ACHC aminocyclohexanecarboxylic acid [11C]DASB [11C]3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile [11C]DOPA [11C dihydroxyphenylalanine [11C]DTBZ [11C]Dihydrotetrabenazine [11C]HED [11C]hydroxyephedrine [11C]PiB [11C]Pittsburgh compound B (PIB ([N-methyl-11C]6-Me-BTA-1) CFR Code of Federal Regulations cGMP current Good Manufacturing Practice Ci curie ClogD calculated distribution coefficient at pH 7.4 ClogP calculated partition coefficient CMC chemistry, manufacturing, and controls CMO contract manufacturing organization CNS central nervous system COMT catecholamine O-methyl transferase CSF cerebrospinal fluid CT computed tomography CTA clinical trial application CV cardiovascular CXCR4 CXC-chemokine receptor-4 Da daltons DAT dopamine transporter DBU 1,8-diazabicyclo[5.4.0]undec-7-ene DDD drug discovery and development DIPE di-isopropyl ether DMA N,N-dimethylacetamide DMF N,N-dimethylformamide DMF drug master file DMSO dimethyl sulfoxide DNA deoxyribose nucleic acid DOTA 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid DPA dipicolylamine DPzA dipyrazolylamine Dx dextran EANM European Association of Nuclear Medicine EC electron capture ECD [99mTc]ethylcysteine dimer eCTD electronic common technical document EGFR epidermal growth factor receptor eLINACS electron linear accelerators EMA European Medicines Agency EOB end-of-bombardment EOS end-of-synthesis EP European Pharmacopeia EPI epinephrine EtOH ethanol EU European Union eV electron volt FA fatty acid FAAH fatty acid amide hydrolase [18F]FACBC 1-amino-3-[18F]fluorocyclobutanecarboxylic acid (Fluciclovine, Axumin) FDA Food and Drug Administration [18F]FDG 2-deoxy-2-[18F]fluoro-D-glucose FDH formate dehydrogenase [18F]FDOPA 6-[18F]fluorodihydroxyphenylalanine [18F]FES [18F]fluoroestradiol [18F]FET 2-[18F]fluoroethyl)-L-tyrosine [18F]FMISO [18F]fluoromisonidazole [18F]FMT [18F]fluoromethyltyrosine [18F]FPEB [18F]3-fluoro-5-(pyridin-2- ylethynyl)benzonitrile [18F]FSPG (S-4-(3-[18F]fluoropropyl)-L-glutamic acid g gram GABA gamma amino butyric acid GC gas chromatography GIST gastrointestinal stromal tumors GLP Good Laboratory Practice GMP Good Manufacturing Practice HBED N,N'-bis(2-hydroxybenzyl)ethylendiamine-N,N'-diacetic acid HDA hexadecanoic acid HER human epidermal growth factor receptor HEU highly enriched uranium HITS high-throughput screening HIV/AIDS human immunodeficiency virus/ acquired immunodeficiency syndrome HMPAO [99mTc]hexamethylpropyleneamine oxime HMR heart mediastinal ratio HPLC high-performance liquid chromatography HSA human serum albumin HYNIC hydrazinonicotinamide IAEA International Atomic Energy Agency IB investigators brochure IBZM iodobenzamide ICH International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use ID injected dose ID/g injected dose per gram IHC immunohistochemistry IMPD investigational medicinal product dossier IMZ iomazenil IND investigational new drug iNOS inducible nitric oxide synthase IVS interventricular septum Kd equilibrium dissociation constant, affinity of ligand toward the target LAF laminar air flow LET linear energy transfer LV left ventricular MAA macroaggregated albumin ... mAb monoclonal antibody