Handbook of Mutagenicity Test Procedures
2nd Edition
Published on 2. December 2012
876 pages
978-0-444-60098-1 (ISBN)
Description
The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.
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Handbook of Mutagenicity Test Procedures
Book
03/1984
2nd Edition
Elsevier
€253.86
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Content
Preface to the First EditionPreface to the Second EditionList of Contributors Chapter 1. Newer Methods for Determining Genotoxicity Using DNA Repair-Deficient and Repair-Proficient Escherichia coliChapter 2. Bacillus Subtilis Repair TestChapter 3. Methods for Studying Excision Repair of Eukaryotic DNA Damaged by Physical and Chemical MutagensChapter 4. Methods for Detecting Carcinogens and Mutagens with the Alkaline Elution/Rat Hepatocyte assayChapter 5. Induced Reversion Using Human AdenovirusChapter 6. Revised Methods for the Salmonella Mutagenicity TestChapter 7. The Fluctuation Test in BacteriaChapter 8. Mutagen Testing Using TRP+ Reversion in Escherichia coliChapter 9. Methodologies for the Direct and Animal-Mediated Determination of Various Genetic Effects in Derivatives of Strain 343/113 of Escherichia coliChapter 10. Basic Principles and Methods of Genotoxicity Testing in the Yeast Saccharomyces CerevisiaeChapter 11. Procedures for the L5178y/TK+/- ¿ TK-/- Mouse Lymphoma Cell Mutagenicity assayChapter 12. a Quantitative Test for Mutagenicity in V79 Chinese Hamster CellsChapter 13. Genetic Markers for Quantitative Mutagenesis Studies in Chinese Hamster Ovary Cells: Applications to Mutagen Screening StudiesChapter 14. Chemical Mutagenesis with Diploid Human FibroblastsChapter 15. 6-Thioguanine-Resistant Lymphocytes in Human BloodChapter 16. The Specific Locus Test in the MouseChapter 17. Procedures and Evaluation of Results of the Mouse Spot TestChapter 18. Human Peripheral Blood Lymphocytes for the Analysis of Chromosome Aberrations in Mutagen TestsChapter 19. In Vitro Anaphase and Metaphase Preparations in Mutation TestingChapter 20. The Bone Marrow Micronucleus TestChapter 21. Cytogenetic Analysis of Structural Chromosome Aberrations and Aneuploidies in Oocytes, Zygotes and Preimplantation Embryos of MammalsChapter 22. The Dominant Lethal assay in the Male MouseChapter 23. Test for Heritable Translocations in Male MammalsChapter 24. The Methodology of Sister Chromatid ExchangesChapter 25. Root Tips of Vicia Fab a for the Study of the Induction of Chromosomal Aberrations and Sister Chromatid Exchanges Chapter 26. Drosophila as An assay System for Detecting Genetic ChangesChapter 27. Eye Pigmentation Changes in Drosophila Melanogaster as a Sensitive Test for MutagenicityChapter 28. Metabolic Activation Systems in Short-Term In Vitro TestsChapter 29. The Intraperitoneal Host-Mediated assayChapter 30. The Isolated Perfused Liver as a Metabolizing System in Mutagenicity TestingChapter 31. The Detection of Induced Chromosome Aneuploidy Using Strains of the Yeast Saccharomyces CerevisiaeChapter 32. Methods for Detecting The Induction of Mitotic Chromosomal Misdistribution in aspergillus NidulansChapter 33. Systems for Detecting Meiotic Aneuploidy in Sordaria and NeurosporaChapter 34. Sperm Morphology Testing in MiceChapter 35. Safety Precautions in Work with Mutagenic and Carcinogenic ChemicalsChapter 36. Handling of Mutagenic Chemicals: Experimental SafetyChapter 37. aspects of Statistical Inference in Testing for Genetic ToxicityChapter 38. Prevention, Detection and Control of Mycoplasmal Infection of Cell CulturesChapter 39. Mutation Epidemiology and Its Prospects for Detecting Human Germinal MutagensIndex
