Immune Regulators In Transfer Factor
Published on 2. December 2012
786 pages
978-0-323-14254-0 (ISBN)
Description
Immune Regulators in Transfer Factor is a collection of papers presented at the Third International Symposium on Transfer Factor held on October 12-14, 1978 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors focus on immune regulators occurring in transfer factor, a dialyzable component of leukocyte lysates. The isolation and characterization of the immunologically active molecules, as well as tests for in vitro and in vivo, are described. This volume is organized into five sections encompassing 73 chapters and begins with an overview of animal models used in research on dialyzable leukocyte extracts, their modulation of suppressor activity, effects in mice, and activity and specificity of human and bovine transfer factor. The next section considers in vitro testing, touching on topics such as the quantification and biological assays of transfer factor; the specificity of transfer factor action on macrophage migration; and the effect of transfer factor therapy on antibody-dependent cytotoxic activity in humans. The reader is then introduced to the preparation, purification, and characterization of transfer factor, as well as clinical investigations ranging from phase I studies to randomized controlled trials. This book will be of interest to scientists and researchers in fields such as molecular medicine, biomedicine, microbiology, immunology, oncology, pathology, and immunotherapy.
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Immune Regulators in Transfer Factor
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01/1979
Academic Press
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Content
List of ParticipantsPrefaceAcknowledgmentsSection I Animal Models Introductory Remarks Modulation of Suppressor Activity by Treatment with Dialyzable Leucocyte Extract Evidence for Specific and Nonspecific Effects of Dialyzable Leukocyte Extracts (Containing Transfer Activity) in Mice A Murine Model for Studying the Transfer of DTH with Dialyzable Human Transfer Factor Bovine Dialyzable Transfer Factor: Stimulation of Antigen-Specific Leukocyte Reactivity in C57BL/6 Mice Guinea Pig as an Experimental Model for Testing Activity and Specificity of Human and Bovine Transfer Factor Specificity Determinants of Dialyzable Transfer Factor (DTF) in the Rhesus Monkey Model Nonspecificity of the Transfer of KLH Hypersensitivity to Marmoset Monkeys with TFd Prepared from the Leucocytes of KLH-Sensitive Rhesus Monkeys The in Vitro Augmentation of Antigen-Induced Proliferation of Spleen Cells Obtained from Human Dialyzable Leukocyte Lysate (HDLL)-Recipient Mice Sensitized to KLH Detection of a New Protein Component in Canine Plasma after Transfer Factor Administration: Correlation with Delayed-Type Skin ReactivitySection II In Vitro Testing Introductory Remarks Induction of Cortisone Resistance and Increased Mitogen Responsiveness in Thymocytes by Transfer Factor Effects of Transfer Factor (TF) and Thymosin on the Recovery of E-Rosetting Capacity in Trypsinised Lymphocytes Contribution of Prostaglandins to the Biological Activity of Dialyzable Leukocyte Extracts Containing Transfer Factor Activity Quantification and Biological Assays of Transfer Factor In Vitro Effects of Bovine Dialyzable Lymph Node Extracts on Human Cell-Mediated Immunity Effects of Human Dialyzable Leukocyte Extract on the Leukocyte Migration Inhibition Assay Possible Identification of an Antigen-Independent Leukocyte Migration Inhibitory Activity in Human Dialyzable Leukocyte Extracts as Neutrophil Immobilizing Factor In Vitro Augmentation of LIF Synthesis by Transfer Factor and by Its Components L-Serine and Glycine The Relationship of L-Serine, O-Phospho-L-Serine, and Glycine to the in Vitro Activity of Human Transfer Factor Mechanism of the in Vitro Augmentation of Lymphocyte Transformation by Transfer Factor and by Other Cellular Dialysates Augmentation of Lymphocyte Transformation: An Assay for Transfer Factor? Specificity of Transfer Factor Action on Macrophage Migration Effect of Transfer Factor Therapy on Antibody-Dependent Cytotoxic Activity in HumansSection III Preparation, Purification and Characterization Introductory Remarks Comparison of Polymorphonuclear and Mononuclear Cell "Transfer Factor" Preparation Transfer of DTH to SK-SD and Tetanus Toxoid in BALB/c Mice by TFd Prepared from Purified Subpopulations of Murine Lymphocytes Comparison of Different Modes of Lymphapheresis for Transfer Factor Concern for Variables in Production of Transfer Factor in Relationship to Different Biological Activities Obtained In Vitro Produced Transfer Factor: Clinical Observations and Antiviral Activity Variations of Antitumor Antibodies in Patients Treated with Transfer Factor Modification of Intradermal Delayed Hypersensitivity by Components of Leukocyte Dialysates Production of Rabbit Antibodies to Human Leukocyte Dialysates Containing Transfer Factor (TFd) Appearance of New Components in Guinea Pig T-Cell Extracts after Sensitization A Structural Model for Human Transfer Factor Suggested by Enzymatic Susceptibilities Biological Activity and Characterization of Immunopeptide Transfer of Cutaneous DTH with Human TFd to BALB/c Mice: Partial Purification of Active Components Purification and Structural Analysis of the Transfer Factorlike Activity Detected in Vitro by Leukocyte Migration InhibitionSection IV Clinical InvestigationPart 1 Introductory Remarks Intravenous Long-Term Transfer Factor Therapy Oral Administration of Bovine and Human Dialyzable Transfer Factor to Human Volunteers Modulation of Immunoglobulin Synthesis in Vi
