Pharmaceutical Polymer Formulations and its Applications
Description
The book is an essential resource for anyone in the pharmaceutical field, as it provides in-depth insights into the versatile roles of polymers in controlled drug delivery, highlighting their critical applications in product innovation, development, and manufacturing.
Pharmaceutical Polymer Formulations and Its Applications provides an overview of the applications of pharmaceutical polymers in the vast field of controlled drug delivery. Polymers have the potential for a range of uses in the design of pharmaceutical dosage forms. They can be used as suspending, emulsifying, binding, or flocculant agents, as well as adhesives and packaging and coating materials. They can be used to make gels, nanoparticles, microparticles, and various capsules. Polymers have played an indispensable role in the manufacture of pharmaceutical products. This volume includes various polymers used in pharmacy based on their applications. The overviews focus on the use of pharmaceutical polymers for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined, and applications of polymers for controlled drug delivery are also discussed.
Readers will find the book:
- Explores the latest tactics utilized for the application of polymers in the healthcare industry;
- Showcases the numerous innovations of polymers in manufacturing of pharmaceuticals;
- Provides essential elements for the conceptualization and comprehension of polymer products by highlighting their aspects and overcoming manufacturing, regulatory, and quality control obstacles.
Audience
The book will interest chemists and healthcare professionals interested in pharmaceutical innovation using polymers.
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Persons
Raj K. Keservani, PhD is a professor on the Pharmacy faculty at the Chhatrapati Shahu Ji Maharaj Group of Institutions, with over 12 years of teaching experience. He has published over 30 peer-reviewed papers in national and international journals, six patents, over 70 book chapters, three co-authored books, and over 40 edited books. He is also active as a reviewer for several international scientific journals. His research interests include nutraceutical and functional foods, novel drug delivery systems (NDDS), transdermal drug delivery, health science, cancer biology, and neurobiology.
Eknath D. Ahire, PhD is an assistant professor in the Department of Pharmaceutics at MET's Institute of Pharmacy in Bhujbal Knowledge City with over six years of experience. He is a reviewer for 15 reputed international journals and serves as an associate editor and editorial advisory board member with different journals. He has over 110 publications in national and international journals, as well as eight textbooks and six edited books. His research interests include nanotechnology-based drug delivery systems, novel drug delivery systems, and nutraceuticals.
Rajesh K. Kesharwani, PhD is an associate professor in the Department of Computer Applications at Nehru Gram Bharati University with over 11 years of experience. He has authored over 55 peer-reviewed articles, 35 book chapters, and 27 edited books with international publishers. He is a reviewer for many international journals and has presented many papers at various national and international conferences. His research interests include medical informatics, protein structure and function prediction, computer-aided drug designing, structural biology, drug delivery, cancer biology, and nanobiotechnology.
Content
Preface xxiii
1 Overview and Introduction of Polymers Used in Pharmaceuticals 1
Nikhil Rajnani, Nalini Kurup, Nikita Rajnani and Selvakumar Sambandan
1.1 Introduction 2
1.2 Classification of Polymers 2
1.3 Ideal Characteristics of Polymer 4
1.4 Characterization of Polymer 4
1.5 Applications of Polymers in Drug Delivery System 5
1.6 Conclusions 11
Acknowledgement 11
References 11
2 Biopolymers as Potential Carriers in the Novel Drug Delivery System 17
Madhuri D. Deshmukh, Eknath D. Ahire, Moreshwar P. Patil, Prasad Rayte, Sheetal Gosavi, Shruti S. Moarnkar and Amit Kumar Rajora
2.1 Introduction 18
2.2 Classification 18
2.3 Properties of Biopolymer 22
2.4 Characterization Techniques of Biopolymer 23
2.5 Frequently Studied Biopolymers 27
2.6 Future Prospective 33
2.7 Conclusion 33
Acknowledgements 34
References 34
3 Functional Polymers as Drug Carriers in Pharmaceuticals Development 41
Eknath D. Ahire, Gangadhar Magar, Shruti Morankar and Amit Kumar Rajora
3.1 Introduction 42
3.2 Polymers' Role in Drug Delivery 45
3.3 Biomaterials for Delivery Systems 46
3.4 Polymers for Medication Delivery 46
3.5 How Polymers Release Drugs 49
3.6 Polymeric System Selection Criteria 50
3.7 Applications 58
3.8 Conclusion and Future Trends 63
Acknowledgements 64
References 64
4 Nanopolymer for Drug Delivery 71
Anju, Mishra Prakash Shyambabu, Amit Kumar Singh and Shanti Bhushan Mishra
4.1 Introduction 72
4.2 Classification of Polymer Nanoparticles 72
4.3 Polymers Used in the Manufacturing of PNPs 74
4.4 Conventionally Used Methods for Making Polymeric Nanoparticles (PNPS) 75
4.5 Pros and Cons of Polymeric Nanoparticles 80
4.6 Characterizing Polymeric Nanoparticles 81
4.7 Controlled Drug Delivery Polymeric Nanoparticles 84
4.8 Applications of Polymeric Nanoparticles 85
4.9 Recent Advances in the Field of PNPs 90
4.10 Future Prospects and Challenges 93
4.11 Conclusion 94
Acknowledgement 95
References 95
5 Natural Polymers for Drug Delivery 105
Mishra Prakash Shyambabu, Mukul Maurya, Amit Kumar Singh, Pradeep Kumar Vishwakarma and Shanti Bhushan Mishra
5.1 Introduction 106
5.2 General Methods of Extraction for Natural Polymers 108
5.3 Plant-Based Natural Polymers 111
5.4 Animal-Based Natural Polymers 119
5.5 Microorganism-Based Natural Polymers 123
5.6 Marine-Based Natural Polymers 127
5.7 Conclusion 131
Acknowledgement 131
References 131
6 Intelligent Drug Delivery Systems for Safe and Effective Cancer Treatment: Smart Bio-Responsive Polymers 143
Siva Nageswara Rao Gajula and Lakshmi Vineela Nalla
6.1 Introduction 144
6.2 Smart Materials with Endogenous Triggering 147
6.3 Smart Materials with External Triggers 151
6.4 Biological Perspective 154
6.5 Conclusion and Future Perspective 164
Acknowledgment 165
References 165
7 Polymers and Their Uses in Drug Delivery 181
Shilpa Amit Gajbhiye, Eknath D. Ahire, Moreshwar P. Patil, Preeti R. Meshram and Yogita M. Patil
7.1 Introduction 182
7.2 A Polymeric Drug Delivery System's Fundamentals 184
7.3 Classification of Polymers 184
7.4 Types of Polymers Used Depending Upon Their Inherent Property 186
7.5 Traditional Use of Polymers in Drug Delivery 192
7.6 Smart Polymers 192
7.7 Polymers in Novel Drug Delivery Systems 193
7.8 Recent Polymer Drug Delivery System Advances 194
7.9 Conclusion 194
Acknowledgement 195
References 195
8 Polymers in Oral Hygiene and Oral Drug Delivery 207
Kumari Supriya, Eknath D. Ahire, Amit Kumar Rajora and Shruti Morankar
8.1 Introduction 208
8.2 Oral Hygiene 208
8.3 Polymers 209
8.4 History of Oral Polymeric Materials 210
8.5 Dental Polymers Natural and Synthetic 212
8.6 The Use of Polymers in Oral Hygiene 212
8.7 Polymers' Part in the Oral Delivery of Drug 214
8.8 Oral Disease Management 217
8.9 Manufacturing of Dental Products 218
8.10 Polymers in Oral Health 218
8.11 Oral Drug Delivery System 226
8.12 Application of Polymers in Oral Dosage Forms 227
8.13 Conclusions 234
Acknowledgment 235
References 235
9 Polymers in Controlled Drug Delivery System 241
Amruta Balekundri and Eknath D. Ahire
9.1 Introduction 241
9.2 Controlled Drug Delivery 244
9.3 Mechanism of Controlled Drug Delivery System 245
9.4 Polymers in Controlled Drug Delivery System 246
9.5 Conclusion 250
Acknowledgment 250
References 250
10 Polymers: An Update on Their Use in Ocular Drug Delivery Systems and Other Recent Developments 255
Shweta H. Shahare, Hitesh V. Shahare, Yunus N. Ansari, Charulata T. Nemade, Khemchand R. Surana, Rani S. Kankate and Eknath D. Ahire
10.1 Introduction 256
10.2 Ideal Ophthalmic Drug Delivery System Characteristics 257
10.3 Routes of Administration of ODDS 257
10.4 Approaches for Ophthalmic Drug Delivery System 258
10.5 Polymers in the Delivery of Drug to the Eyes 263
10.6 Conclusion 267
Acknowledgement 267
References 267
11 Polymers and Approaches in Dental Preparations 273
Hitesh V. Shahare, Yunus N. Ansari, Eknath D. Ahire, Kavita R. Chandramore, Kshtija P. Deshmukh, Shweta H. Shahare and Deepti G. Phadtare
11.1 Introduction 273
11.2 Polymers Used in Dentistry 276
11.3 Branches of Dentistry 279
11.4 Properties of Polymers 279
11.5 Applications of Polymers in Dentistry 281
11.6 Recent Advancements in Use of Polymers in Dentistry 284
11.7 Conclusion 286
Acknowledgment 286
References 286
12 Role and Types of Polymers Used in Cosmetics 291
Shweta H. Shahare, Bhavesh B. Amrute, Hitesh V. Shahare, Nayana S. Baste, Eknath D. Ahire, Parag A. Pathade and Sandhya Borse
12.1 Introduction 291
12.2 Classification of Cosmetics 292
12.4 Polymers in Cosmetics 296
12.5 Natural Polymers 297
12.7 Synthetic Polymers 302
12.8 Conclusion 304
Acknowledgement 304
References 305
13 Potential Natural Polymers in the Modern Drug Delivery Systems 309
Maruti K. Shelar and Shubhangi V. Shekade
13.1 Introduction 310
13.2 Type of Modern Drug Delivery System 311
13.3 Conclusion 326
Acknowledgments 326
References 326
14 Polymers in Nutritional Applications 333
Shilpa Amit Gajbhiye, Eknath D. Ahire, Preeti R. Meshram and Yogita M. Patil
14.1 Introduction 333
14.2 Classification 334
14.3 Advantages 336
14.4 Disadvantages 337
14.5 Application of Nutritional Polymer 338
14.6 Current Innovative Research in the Field of Nutritional Polymer 339
14.7 Future Perception to Nutritional Polymer Research 341
14.8 Conclusion 345
Acknowledgement 345
References 346
15 Green Polymers and Their Uses in Pharmacy 349
Pavan Kumar Padarthi, Kore Kakasaheb Jagannath, Varsha Deva, Sudhahar Dharmalingam, Santosh Karajgi, V. Rao, Manchineni Prasada Rao and Senthil Prabhu Rajendran
15.1 Introduction 350
15.2 Natural (Green) Polymer 352
15.3 Future Indications 359
15.4 Conclusion 360
References 361
16 Polymers in Gene Delivery 367
Niloufer K. Kotwal, Rishi Pal, Sultana Razia, Jaffar Shaik and Meenakshi Jaiswal
16.1 Introduction 368
16.2 Application of Polymers in Gene Delivery 370
16.3 Methods for Delivering Genes 370
16.4 Polymers Used 371
16.5 Future Prospective 379
16.6 Conclusion 379
References 380
17 Introduction, Overview and Various Uses of Synthetic Polymers in Pharmacy 385
Rajesh Kumar, Jyoti Prakash, Anmol Gautam, Gaurav Dhiman, Pradeep Saha, Dhruv Dev and Mohammad Shahnaz
17.1 Introduction 385
17.2 Synthetic Polymers in Pharmaceutical Formulation Developments 388
17.3 Synthetic Polymer-Conjugates Applications in Pharmaceuticals 393
17.4 Applications 395
17.5 Future Prospects 396
17.6 Conclusion 397
References 397
18 Semiconducting Polymer 405
Senthil Prabhu Rajendran
18.1 Introduction 405
18.2 Polymers that are Conjugated as Semiconductors 408
18.3 Polymers with Semiconducting Properties 409
18.4 Applications of Semiconducting Polymers in Pharmaceutical and Medical Sciences Neural Applications 410
18.5 Conclusion 413
References 414
19 Nanostructured Polymer Systems and Pharmacy 421
K. Bhaskar Reddy, Vishal Satish Patil, P.S. Minhas, Madhusmruti Khandai, Varinder Soni, V. Ragini, Sanjesh Kumar Gotam Rathi and Dhruv Dev
19.1 Introduction 422
19.2 Nanostructured Polymers 424
19.3 Utilization of Polymeric Nanostructured Systems in the Drug Delivery System Nanocapsules 425
19.4 Future Perspective 432
19.5 Conclusion 433
References 434
20 Microstructured Polymer System and Its Application in Pharmacy 441
Anasuya Patil, Kavita Vijay, P.S. Minhas, Mahaveer Singh, Ashish Ashokkumar Jaiswal, Sandeep Sharma and Vaibhav Dagaji Aher
20.1 Introduction 442
20.2 Pharmaceutical Products Using Micro/Nanostructured Polymeric Materials 444
20.3 Polymeric Polymers as Pharmaceutical Drug Delivery Matrices 445
20.4 Methods for Preparing Nano- and Microparticles 453
20.5 Future Perspective 457
20.6 Conclusion 458
References 458
Index 467
