Basic Clinical Radiobiology
6th Edition
Published on 8. January 2025
360 pages
978-1-040-19426-3 (ISBN)
Description
The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy. As previously, a multi-national authorship includes some of the top radiation oncologists, biologists, and physicists from North America and Europe, who highlight the core principles of radiobiology.
More details
Edition
6th edition
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
Professional and scholarly
Illustrations
48 Tables, black and white; 175 Line drawings, color; 6 Line drawings, black and white; 13 Halftones, color; 1 Halftones, black and white; 188 Illustrations, color; 7 Illustrations, black and white
ISBN-13
978-1-040-19426-3 (9781040194263)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Michael C. Joiner | Albert van der KogeJ. l
Basic Clinical Radiobiology
Book
01/2025
6th Edition
CRC Press
€298.50
Shipment within 10-20 days
Michael C. Joiner | Albert van der KogeJ. l
Basic Clinical Radiobiology
Book
01/2025
6th Edition
CRC Press
€123.50
Shipment within 10-20 days
Persons
Michael C. Joiner, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at Wayne State University, Detroit, Michigan, USA.
Albert J. van der Kogel, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.
Albert J. van der Kogel, PhD, is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.
Content
Preface
About the editors
List of contributors
Glossary
1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment. 2. Irradiation-induced damage and the DNA damage response. 3. Cell death after irradiation - how, when and why cells die. 4. Quantifying cell kill and cell survival. 5. Radiation dose-response relationships. 6. Linear energy transfer and relative biological effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8. Tumour growth and response to radiation. 9. Fractionation: The Linear-Quadratic approach. 10. The linear-quadratic approach in clinical practice. 11. Modified fractionation. 12. Early effects in epithelial tissues, the role of stem cells and time factors. 13. The dose-rate effect. 14. Pathogenesis of late normal tissue effects. 15. Volume effects, regional responses, and risk models. 16. Biological modifiers of normal tissue effects. 17. The oxygen effect and therapeutic approaches to tumour hypoxia. 18. The tumour microenvironment and cellular hypoxia responses. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy. 22. Molecular image guided radiotherapy. 23. Retreatment tolerance of normal tissues. 24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical aspects. 26. Radiation and the immune system. 27. Second cancers after radiotherapy.
Index
About the editors
List of contributors
Glossary
1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment. 2. Irradiation-induced damage and the DNA damage response. 3. Cell death after irradiation - how, when and why cells die. 4. Quantifying cell kill and cell survival. 5. Radiation dose-response relationships. 6. Linear energy transfer and relative biological effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8. Tumour growth and response to radiation. 9. Fractionation: The Linear-Quadratic approach. 10. The linear-quadratic approach in clinical practice. 11. Modified fractionation. 12. Early effects in epithelial tissues, the role of stem cells and time factors. 13. The dose-rate effect. 14. Pathogenesis of late normal tissue effects. 15. Volume effects, regional responses, and risk models. 16. Biological modifiers of normal tissue effects. 17. The oxygen effect and therapeutic approaches to tumour hypoxia. 18. The tumour microenvironment and cellular hypoxia responses. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy. 22. Molecular image guided radiotherapy. 23. Retreatment tolerance of normal tissues. 24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical aspects. 26. Radiation and the immune system. 27. Second cancers after radiotherapy.
Index
