Controversial issues in cardiac pathophysiology

The cross-bridge cycle in muscle. Mechanical, biochemical, and structural studies on single skinned rabbit psoas fibers to characterize cross-bridge kinetics in muscle for correlation with the actomyosin-ATPase in solution.- Calcium sensitivity of myofilaments in cardiac muscle - effect of myosin phosphorylation.- Ca-pools involved in the regulation of cardiac contraction under positive inotropy. X-ray microanalysis on rapidly-frozen ventricular muscles of guinea-pig.- The contribution of Na channel block to the negative inotropic effect of antiarrhythmic drugs.- Cardiac oxygen consumption and systolic pressure volume area.- The concept of "end-systolic" pressure-volume and length-tension relations of the heart from a muscle physiologist's point of view.- Local myocardial and global ventricular function compared during positive inotropic medication.- On the role of optimization in the cardiovascular system.- Some problems of cardiac energetics.- Myothermal economy of rat myocardium, chronic adaptation versus acute inotropism.- The influence of myosin isoenzyme pattern on increase in myocardial oxygen consumption induced by catecholamines.- Function and energy-rich phosphate content of the hypertrophied ventricle after global ischemia and reperfusion.- Metabolic aspects of the development of experimental cardiac hypertrophy.- Intracellular turnover and cardiac hypertrophy.- Correlation between total catecholamine content and redistribution of myosin isoenzymes in pressure loaded ventricular myocardium of the spontaneously hypertensive rat.- Significance of physical exercise in hypertension. Influence of water temperature and beta-blockade on blood pressure, degree of cardiac hypertrophy and cardiac function in swimming training of spontaneously hypertensiverats.- Basis and clinical significance of regression of hypertensive hypertrophy.- Histochemically determinable changes in cardiac insufficiency and their functional significance.- Morphological reaction patterns in experimental cardiac hypertrophy - a quantitative stereological study.- Pathophysiological mechanisms in cardiac insufficiency induced by chronic pressure overload - an attempt to analyze specific factors in animal experiment.- Immunologic regulator and effector functions in perimyocarditis, postmyocarditic heart muscle disease and dilated cardiomyopathy.- Alterations of ?-adrenoceptors subsequent to myocardial infarction.