Brain Signal Transduction and Memory
Published on 2. December 2012
310 pages
978-0-323-15658-5 (ISBN)
Description
Brain Signal Transduction and Memory is a compilation of the proceedings of the Fifth Takeda Science Foundation Symposium on Bioscience, held on November 28-30, 1988, in Kyoto, Japan. The symposium provided a forum for the discussion of a wide range of topics on brain signal transduction and its role in memory formation. Topics covered include the role of phosphoinositides in neural signaling; the homeostasis of calcium ions; the involvement of protein kinase C in brain signal transduction and memory formation; long-term potentiation in the hippocampus; synaptic plasticity and memory; and organization of neural tissues by plasticity. This book is comprised of 21 chapters and begins with an analysis of the phosphoinositide signaling system and how it might function within the nervous system, followed by a discussion on the molecular heterogeneity of the protein kinase C family and its implications for the regulation of neuronal cells. The formation and reorganization of synaptic contacts in the developing nervous system, as well as the factors that influence the plasticity of this process, are then explored. Other chapters focus on the biochemical mechanisms involved in the generation and maintenance of enhanced synaptic transmission; quantal release in the hippocampus; molecular mechanisms of long-term depression in the cerebellum; and cellular mechanisms for reorganization of synaptic inputs after early brain damage. This monograph will appeal to biologists, physiologists, bioscientists, and clinicians.
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Masao Ito | Y. Nishizuka
Brain Signal Transduction and Memory
Book
07/1997
Academic Press
€71.80
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Content
ForewordPrefaceI. Overviews Phosphoinositides and Neural Signaling The Heterogeneity of Protein Kinase C and Its Implications for Neuronal Cell Regulation Molecular Mechanisms for Long-Term Memory in AplysiaII. Homeostasis of Calcium Ions Mechanisms Underlying the Generation and Control of [Ca2-]i Transients in Neurons and Neurosecretory Cells Heterogeneous Distribution and Temporal Changes of Cytoplasmic Free Calcium in Gastric Parietal Cells and Platelets The Role of Ca2+/Calmodulin-Dependent Protein Kinase II in Neuronal FunctionsIII. Involvement of Protein Kinase C Cytochemical Evidence of Protein Kinase C in Neuronal Tissues The Protein Kinase C Substrate Protein B-50 in Neural Signal Transduction and Plasticity Modulation of Two K + Currents by Inositol Trisphosphate and Protein Kinase C The Role of Protein Kinase C and Phosphoinositide Metabolites in Neurons That Control Prolonged Reproductive Behaviors in AplysiaIV. Long-Term Potentiation in the Hippocampus Quantal Release in the Hippocampus Mechanisms Involved in the Initiation and Expression of Long-term Potentiation Cholinergic and Noradrenergic Modulation of Long-Term Potentiation in Hippocampal CA3 Neurons Presynaptic Mechanisms Underlying the Maintenance of Long-term Potentiation in the HippocampusV. Synaptic Plasticity and Memory Molecular Mechanisms of Long-Term Depression in the Cerebellum Molecular Basis for the Hebb Synapse The Physical Reality of Memory Molecular Mechanisms Underlying Synaptic Plasticity in the Developing Visual CortexVI. Organization of Neural Tissues by Plasticity Terminal Sprouting and Functional Plasticity at Neuromuscular Junctions Roles of Nerve Growth Factor in the Central Nervous System Cellular Mechanisms for Reorganization of Synaptic Inputs after Early Brain DamageIndex
