Inter-Organellar Ca2+ Signaling in Health and Disease - Part A
Academic Press
Published on 9. July 2021
308 pages
978-0-12-824035-9 (ISBN)
Description
Inter-Organellar Ca2+ Signaling in Health and Disease - Part A, Volume 362, the latest release in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the International Review of Cell and Molecular Biology series
- Updated release includes the latest information on the topic of Inter-Organellar Ca2+ Signaling in Health and Disease - Part A
More details
Other editions
Additional editions
Lorenzo Galluzzi | Saverio Marchi
Inter-Organellar Ca2+ Signaling in Health and Disease - Part A: Volume 362
Book
07/2021
Academic Press
€231.50
Shipment within 15-20 days
Persons
Content
- Intro
- Inter-Organellar Ca2+ Signaling in Health and Disease - Part A
- Copyright
- Contents
- Contributors
- Preface: Ca2+ in health and disease
- Acknowledgments
- Conflict of interest statement
- References
- Chapter One: Calcium signaling in neuroglia
- 1. Introduction: Supportive and protective neuroglia
- 2. Glial cells
- 2.1. Astrocytes
- 2.1.1. Protoplasmic astrocytes
- 2.1.2. Fibrous astrocytes
- 2.1.3. Juxtavascular astrocytes
- 2.1.4. Surface-associated astrocytes
- 2.1.5. Velate astrocytes
- 2.1.6. Pituicytes
- 2.1.7. Perivascular and marginal astrocytes
- 2.1.8. Glia limitans
- 2.1.9. Gomori astrocytes
- 2.1.10. Ependymocytes, choroid plexus cells and retinal pigment epithelial cells
- 2.1.11. Radial astrocytes
- 2.1.12. Human-specific astroglia
- 2.2. Oligodendrocytes
- 2.3. Microglia
- 3. Astrocytic Ca signaling
- 3.1. Ca as a second messenger
- 3.2. Astroglial Ca homeostasis
- 3.2.1. Intracellular Ca]i in astrocytes
- 3.2.2. Astrocytes possess a special form of excitability
- 3.2.3. Astroglial Ca excitability
- 3.2.3.1. Metabotropic receptors, ER Ca entry
- 3.2.3.2. Ca entry
- 3.3. Astrocytic Ca signals display a remarkable diversity
- 3.4. Functional significance of Ca signals in astrocytes
- 4. Ca signaling in oligodendrocytes
- 5. Ca signaling in microglia
- 6. Conclusions
- Acknowledgments
- References
- Chapter Two: Ca homeostasis in brain microvascular endothelial cells
- 1. Introduction
- 2. Calcium measurements in brain microvascular endothelial cells
- 2.1. Calcium measurements in cell cultures
- 2.2. Calcium measurements in freshly isolated brain endothelium
- 2.3. Measurements of in vivo calcium waves
- 3. Ion channels/receptors regulating Ca homeostasis in brain microvascular endothelial cells
- 3.1. TRP channels
- 3.2. Purinergic receptors
- 3.3. Bradykinin receptors
- 3.4. Muscarinic receptors
- 4. Ca homeostasis and cytoskeleton organization in the blood brain barrier
- 4.1. The cytoskeleton of brain microvascular endothelial cells
- 4.2. Relation between Ca homeostasis and cytoskeleton remodeling and function in brain microvascular endothelial cells
- 5. Alterations of Ca homeostasis in the blood brain barrier associated with neuropathologies
- 5.1. Alterations of Ca homeostasis in BBB associated with epilepsy
- 5.2. Alterations of Ca homeostasis in BBB associated with Alzheimer´s disease
- 5.3. Alterations of Ca homeostasis in BBB associated with Parkinson´s disease
- 5.4. Alterations of Ca homeostasis in BBB associated with amyotrophic lateral sclerosis
- 5.5. Alterations of Ca homeostasis in BBB associated with ischemic stroke
- 6. Opening of the blood brain barrier and its role in CNS chemotherapy
- 6.1. Osmotic opening of the blood brain barrier
- 6.2. Opening of the blood brain barrier by the activation of bradykinin B2 receptors
- 6.3. Ultrasound opening of the blood brain barrier
- Acknowledgments
- References
- Chapter Three: Mitochondrial calcium homeostasis in hematopoietic stem cell: Molecular regulation of quiescence, function ...
- 1. Introduction
- 2. Intracellular Ca homeostasis in HSC maintenance and commitment
- 2.1. Ca driven commitment of HSC
- 2.2. Ca control of HSC quiescence
- 3. Mitochondrial calcium in HSC regulation
- 4. Calcium homeostasis deregulation in malignant hematopoiesis
- 5. Conclusion
- Author contributions
- Funding
- Conflicts of interest
- References
- Chapter Four: Lysosomal calcium and autophagy
- 1. Introduction
- 2. Endolysosomal calcium channels
- 3. Two-pore channels (TPCs)
- 4. Two-pore channels (TPCs) and autophagy pathway
- 5. TRPMLs
- 6. TRPML1 and autophagy
- 7. TRPML1 and chaperone-mediated autophagy (CMA)
- 8. TRPML3 and autophagy
- 9. Lysosomal calcium and selective autophagy
- 10. Concluding remarks
- Acknowledgments
- References
- Chapter Five: Mitochondrial Ca and cell cycle regulation
- 1. Introduction
- 2. Cytosolic calcium signaling during the cell cycle
- 3. Mitochondrial Ca uniporter complex (MCUC) and its regulatory mechanisms
- 3.1. Extramitochondrial Ca elevation as the driving signal
- 3.2. Mitochondrial Ca sensing mechanism
- 3.3. Post-translational modification of MCU
- 4. Mitochondrial calcium signaling during the cell cycle
- 4.1. Facilitating energy production and mitochondrial metabolism
- 4.2. Reactive oxygen species (ROS) production
- 4.3. Mitochondrial permeability transition pore (mPTP) opening
- 4.4. Cytosolic Ca buffering and signaling
- 4.5. In vivo evidence of mitochondrial Ca mediated cell cycle regulation
- 4.6. Mitochondrial Ca signaling imaging during the cell cycle
- 5. The mitochondrial calcium uptake mechanism
- 5.1. Fertilization-induced egg activation
- 5.2. Mitosis
- 5.3. G1/S transition
- 5.4. Initiation of hematopoietic stem cells division
- 6. Mitochondrial Ca dependent cell cycle regulation in tumorigenesis
- 7. Conclusions
- Acknowledgments
- Conflict of interest
- References
- Chapter Six: The mitochondrial calcium homeostasis orchestra plays its symphony: Skeletal muscle is the guest of honor
- 1. Introduction
- 2. Physiological roles of mitochondrial calcium uptake
- 3. Calcium transport through the outer mitochondrial membrane
- 4. Calcium transport through the inner mitochondrial membrane
- 5. The mitochondrial calcium uniporter complex
- 5.1. MCU
- 5.2. MCUb
- 5.3. EMRE
- 5.4. MICU proteins
- 6. Mitochondrial calcium extrusion
- 7. Mitochondrial calcium uptake and ROS production
- 8. Mitochondrial calcium accumulation and cell death
- 9. Ca in skeletal muscle: a bidirectional signaling route
- 10. The role of mitochondrial bioenergetics in the control of skeletal muscle function
- 11. Skeletal muscle mitochondrial biogenesis: A nuclear receptor network controls mitochondrial respiratory function and ...
- 12. Impairment of Ca signaling in muscular dystrophy
- 13. Ryanodine receptor myopathies: Neuromuscular disorders affecting EC coupling and Ca homeostasis
- References
- Chapter Seven: Mitochondrial Ca homeostasis in trypanosomes
- 1. Introduction
- 2. The mitochondrial Ca uniporter: Discovery
- 3. The mitochondrial Ca uniporter of trypanosomes: The pore subunits
- 4. The mitochondrial Ca uniporter of trypanosomes: The gatekeeper subunits
- 5. The mitochondrial Ca uniporter of trypanosomes: Interaction with the ATP synthase
- 6. Mechanism of mitochondrial Ca efflux in trypanosomes
- 7. Role of mitochondrial Ca uptake
- 7.1. Cytosolic Ca buffering system
- 7.2. Regulation of mitochondrial metabolism
- 7.3. Regulation of cell survival
- 8. Conclusions and open questions
- Acknowledgments
- References
