Ion Exchange Resins
Biomedical and Environmental Applications
Published on 25. January 2023
174 pages
978-1-64490-221-9 (ISBN)
Description
The book focuses on the applications of ion exchange resins in processes. Keywords: Ion Exchange Resins, Protein Separation and Purification, Partition and Purgation of Vitamins, Toxic Heavy Metal Ions, Bioactive Molecules, Sustained Drug Release, Ion-Exchange Chromatography, Clinical Applications, Electrodialysis, Ultrasound, Water Softening.
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Inamuddin | Maha Khan | Mohammad Mazumder
Ion Exchange Resins
Biomedical and Environmental Applications
Book
01/2023
Materials Research Forum LLC
€100.90
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Content
- Intro
- front-matter
- Table of Contents
- Preface
- 1
- Applications of Ion Exchange Resins in Protein Separation and Purification
- 1. Introduction
- 2. Types of ion exchange resins
- 3. Functionalization of ion exchange resin
- 4. Characterization of ion exchange resin
- 4.1 Elemental analysis
- 4.2 FT-IR spectra
- 4.3 Thermogravimetric analysis
- 5. Analysis of variables for protein IEC
- 5.1 Stability and pI of proteins
- 5.2 Effect of the support on the chromatographic separation of proteins
- 5.3 Effect of buffer and mobile phase
- 6. Steps of protein separation by IEC
- 7. Types of protein purified by IEC
- 8. Future prospects of IEC
- Acknowledgments
- References
- 2
- Applications of Ion Exchange Resins in Vitamins Separation and Purification
- 1. Introduction
- 2. Importance of vitamins
- 3. Categorisation of vitamins
- 3.1 Water soluble vitamins
- 3.2 Fat soluble vitamins
- 4. Origin of vitamins
- 5. Isolation and purgation of vitamin
- 6. Ion-exchange chromatography
- 7. Ion exchange chromatographic isolation and purgation of vitamin K1
- 8. Ion exchange chromatographic isolation and purgation of vitamin C
- 9. Ion exchange chromatographic isolation and purgation of vitamin B1, vitamin B2 and vitamin B6
- Conclusion
- References
- 3
- Application of Ion Exchange Resins in Protein Separation and Purification
- 1. Basic principle of protein separation and purification by chromatographic method
- 2. Chromatographic methods of protein purification
- 2.1 Gel filtration or permeation chromatography
- 2.2 Affinity chromatography
- 2.3 Immuno affinity chromatography
- 2.4 Metal chelate chromatography
- 2.5 Other Chromatographic techniques
- 3. Principle of separation of proteins by ion exchange chromatography
- 4. Strong and weak ion exchange resin
- 5. Choice of buffer
- 6. Experimental procedure of ion exchange resin
- 6.1 Equilibration
- 6.2 Sample Application and Wash
- 6.3 Elution
- 6.4 Regeneration
- 7. Morphology of ion exchange resin
- 7.1 Capacity of ion exchange resin
- 7.2 Stability
- 7.3 Cross linking of resins
- 7.4 Donnan equilibrium
- 8. Parameters for optimisation of ion exchange methods
- 8.1 Resolution
- 8.2 Efficiency
- 8.3 Selectivity
- Summary
- References
- 4
- Ion Exchange Resins for Selective Separation of Toxic Metals
- 1. Introduction
- 2. Ion exchange resins (IERs)
- 3. Type of IERs
- 4. Synthesis of IERs
- 5. Uses of IERs
- 6. Activity of IERs
- 7. Properties of IERs
- 7.1 IE capacity of resin
- 7.2 Water retention capacity of ion exchange resin
- 7.3 Density of ion exchange resin
- 7.4 Surface area of ion exchange resin
- 7.5 Regeneration of ion exchange resin
- 8. Selectivity of IERs
- 9. Toxic metals
- 10. Selective separation of toxic metals
- 11. Modern ion exchange separation method in industry and its future prospects
- Conclusion
- References
- 5
- Separation and Purification of Bioactive Molecules by Ion Exchange
- 1. Introduction
- 1.1 Reversed phase chromatography
- 2. Polymeric sorbents for preparative chromatography of biologically active compounds
- 2.1 Designing a biochemical purification
- 3. Ion-exchange separation and purification of polyphenols
- 3.1 Separation of bioactive catechin derivatives by AEC
- 4. Ion-exchange separation and purification of protein
- 5. Use of ion-exchange chromatography for the separation of peptide
- 5.1 Separation of human C-peptide by ion exchange
- 6. Separation of Alkaloids from Chinese Medicines by ion-exchange
- 7. Separation of plasmid DNA using ion-exchange chromatography
- 8. Separation of carbohydrates from seaweed using ion-exchange chromatography
- 9. Future Prospects
- References
- 6
- Ion Exchange Resins as Carriers for Sustained Drug Release
- 1. Introduction
- 2. Principles of sustained drug release
- 2.1 Evolution of sustained drug delivery systems
- 2.2.1 First-generation delivery systems
- 2.2.2 Second-generation delivery systems
- 2.2.3 Third/ Next generation delivery systems
- 3. Types of sustained drug delivery systems
- 3.1 Diffusion-controlled system
- 3.1.1 Reservoir system
- 3.1.2 Matrix system
- 3.2 Osmotic system
- 3.3 Floating system
- 3.4 Bioadhesive system
- 3.5 Liposome system
- 4. IERs as drug delivery systems
- 4.1 Chemistry of IERs
- 4.2. Complexation of IER and the drug
- 4.2.1 Selection of the drug
- 4.2.2 Purification of resins
- 4.2.3 Drug loading
- 4.2.3.1 Batch method
- 4.2.3.2 Column method
- 4.2.4 Factors affecting drug loading
- 4.2.4.1 Particle size
- 4.2.4.2 Porosity and swelling
- 4.2.4.3 Available capacity
- 4.2.4.4 Acid-base strength
- 4.2.5 Evaluation of drug resinates
- 5. Modified resinates
- 6. Release kinetics of drugs complexed with IERs
- 7. Efficiency of IERs as the delivery mechanism
- 7.1 Oral drugs
- 7.2 Nasal drugs
- 7.3 Ophthalmic drugs
- 7.4 Oro-dispersible films (ODF)
- 7.5 Oral liquid suspensions
- 8. Commercial IERs used in sustained drug delivery
- 8.1 Dowex 50W
- 8.2 Indion 244
- 8.3 Amberlite IRP-69
- 9. Future perspectives
- References
- 7
- Ion Exchange Resins for Clinical Applications
- 1. Introduction
- 2. Application of resins in formulation-related issues
- 2.1 Taste development
- 2.2 Aiding in dissolution
- 2.3 Role as disintegrating agents
- 2.4 Drug stabilization
- 2.5 Water purification for the production of pharmaceuticals
- 2.6 Anti-deliquescence
- 3. Applications in drug release systems
- 3.1 Simple resinates
- 3.2 Microencapsulated resinates
- 3.3 Hollow fiber system
- 3.4 Gastric retentive system
- 3.5 Sigmoidal release system
- 4. Applications in targeted drug delivery
- 4.1 Oral drug delivery
- 4.2 Nasal drug delivery
- 4.3 Transdermal drug delivery
- 4.4 Ophthalmic drug delivery
- 4.5 Application in cancer treatment
- 5. Applications in therapeutics
- 5.1 High cholesterol treatment
- 5.2 Application in treatment of pruritus
- 5.3 Applications in treating of oedema
- 5.4 Application in the treatment of cardiac oedema
- 5.5 Applications as antacids
- 5.6 Treating uremia
- Conclusion
- References
- 8
- Applications of Ion Exchange Resins in Water Softening
- 1. Introduction
- 2. Water hardness
- 2.1 Salts providing hardness
- 2.2 Negative effect of water hardness
- 3. Ion exchange resins for water softening
- 3.1 Strongly acidic resins
- 3.2 Weakly acidic resins
- 3.3 Polymer-inorganic resins
- 4. Regeneration of ion exchange resins and their fouling
- 5. Ion exchange in a combination with other processes
- 5.1 Ion exchange and ultrasound
- 5.2 Ion exchange and electrodialysis
- Conclusions
- References
- back-matter
- Keyword Index
- About the Editors
