Success in Academic Surgery: Basic Science
Description
This book advises the reader on the mechanics of starting a basic science research career as an academic surgeon. Written by established content experts, the chapters are both comprehensive and practical in their approach. The book includes a suggested timeline for the initial academic appointment, including how to setup and fund the laboratory and identifying appropriate scientific mentors and lab personnel. It also describes the application of basic and advanced research techniques, including animal models, flow cytometry, gene editing, tissue engineering, and microbiome analysis. Success in Academic Surgery: Basic Science is an essential guidebook for senior residents or fellows approaching their first academic appointment, young faculty in the process of establishing their research career, and more senior investigators interested in expanding their research horizons.
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Catherine J. Hunter, MD graduated from Cornell Medical College of Medicine and completed her surgical training at Harbor-UCLA Medical Center. She completed her research fellowship at Children's Hospital of Los Angeles and has been the primary investigator of a funded basic science laboratory for over 10 years. Her laboratory studies the pathophysiology of necrotizing enterocolitis, with a focus on epithelial signalling and tight junction biology. She is currently the Chief of Pediatric Surgery at Oklahoma Children's Hospital and the Children's Hospital Foundation Paula Milburn Miller Chair in Pediatric Surgery.
Vikas Dudeja, MD is Professor with tenure, James P Hayes Endowed Professor and Director of Division of Surgical Oncology at University of Alabama at Birmingham. He completed his bachelor of medicine and surgery at the All India Institute of Medical Sciences (AIIMS) in New Delhi, India. He also received his master of surgery from AIIMS in 2005.Dr. Dudeja spent the next 3 years doing research on the pathogenesis of pancreatic cancer and pancreatitis and developing novel therapies against these diseases. Afterwards he received residency training in general surgery at the University of Minnesota and fellowship in complex general surgical oncology and hepato-pancreato-billiary surgery at Memorial Sloan Kettering Cancer Centre. Dr. Dudeja's clinical practice is focused on taking care of patients with hepato-pancreatico-biliary diseases. On research front, Dr. Dudeja's laboratory focuses on deciphering the biology of tumor microenvironment in pancreatic cancer and interaction of gut microbiome with anti-cancer immune response. In the area of pancreatitis, his laboratory focuses on developing novel treatment for this morbid disease. Currently, he is the initiating PI on two clinical trials evaluating novel drugs in patients with pancreatitis. His research efforts has been funded by grants from National Institute of Health (NIH), Veterans Affairs, Department of Defense and various Society Grants. His work has been published in high impact journals like Gastroenterology, GUT, Clinical Cancer Research and Nature Reviews in Gastroenterology and Hepatology.
Content
How to Establish, Staff, and Fund Your Basic Science or Translational Research Laboratory.- How to Fund Your Basic Science or Translational Research Laboratory.- Choosing a Good Scientific Mentor and Being a Good Mentee.- Effective Time Management Strategies for Conducting Laboratory Research.- Maintaining an Effective Lab Notebook and Data Integrity.- Statistics and Bioinformatics for Bench Research.- Ethics in Laboratory Research.- Modern Techniques for DNA and RNA Assessment.- Modern Techniques for Protein Assessment.- Considerations for Immunohistochemistry and tissue imaging.- Fundamentals of Flow Cytometry and Cytometry by Time of Flight (CyTOF).- Effective Cell and Tissue Culture.- Gene Therapy & Gene Editing Techniques.- Single-cell RNA sequencing technologies and applications: A brief overview.- Stem cells and Tissue Engineering.- Animal Models in Surgical Research.- Overview of Advances in Live Animal Imaging.- The Role of the Microbiome in Surgical Diseases and their Management.- Systems Biology: Generating and Understanding Big Data.
