Current Topics in Cellular Regulation

Control of Metabolism by Dynamic Macromolecular Interactions I. Introduction II. Control of Metabolic Pathways III. Dynamically Organized Enzyme Systems IV. Energetic Aspects V. Concluding Remarks ReferencesLigand Binding and Multienzyme Complex Formation Between Ornithine Carbamoyltransferase and Arginase from Saccharomyces cerevisiae I. Introduction II. Regulation of Arginine Metabolism in Saccharomyces cerevisiae III. Quaternary Structure of Yeast OTCase and Arginase IV. Quaternary Structure of the OTCase-Arginase Multienzyme Complex V. Test for an Ornithine Isosteric Effector Site VI. Intrinsic and Extrinsic Effects ReferencesRegulation of Fatty Acid Uptake and Synthesis in Mammary and Adipose Tissues: Contrasting Roles for Cyclic AMP I. Introduction II. The Cyclic AMP Economy of Mammary Tissue During Lactation III. Acute Regulation of Fatty Acid Uptake and Biosynthesis Processes in Lactating Mammary Tissue IV. Regulation of Acetyl-CoA Carboxylase V. Cyclic AMP-Dependent Protein Phosphorylation in Mammary Epithelial Cells VI. Concluding Remarks ReferencesStructural and Functional Relationships of Guanosine Triphosphate Binding Proteins I. Introduction II. The Role of Guanine Nucleotide Binding Proteins in Hormonal Regulation of Adenylate Cyclase Activity III. The Role of Guanine Nucleotide Binding Proteins in Visual Signal Transmission IV. Novel Guanine Nucleotide Binding Proteins with Other Functions, and Known Guanine Nucleotide Binding Proteins with Novel Functions V. G Protein Structures VI. Summary ReferencesThe Glycogen Storage Disease (gsd/gsd) Rat I. Introduction II. The gsd/gsd Rat III. Perinatal Development in the gsd/gsd Rat IV. Ultrastructure and Morphometry V. Metabolism in Aged gsd/gsd Rats VI. Concluding Remarks References BibliographyFunction and Regulation of the Pentose Phosphate Pathway in Brain I. Introduction II. Measurement of the Pentose Phosphate Pathway III. Contribution of the Pentose Phosphate Pathway to Glucose Metabolism IV. Effects of Activators and Inhibitors on the Pentose Phosphate Pathway in Brain Preparations V. Developmental Changes in the Activity of the Pentose Phosphate Pathway VI. Functional Significance of the Pentose Phosphate Pathway in Brain VII. Summary ReferencesRegulation of Carotenoid Biosynthesis I. Introduction II. Structure and Nomenclature III. Biosynthetic Pathways and Carotenogenic Enzymes IV. Genes Involved in Carotenoid Biosynthesis V. Regulation of Carotenoid Biosynthesis VI. Regulatory Genes VII. Conclusions and Future Studies ReferencesIndex