Current Topics in Cellular Regulation

Enzyme-Enzyme Interactions and the Regulation of Metabolic Reaction Pathways I. The Existence of Enzyme-Enzyme Interactions in Supermolecular Cellular Structures II. The Concentration of Enzymes and Metabolites in Cellular Compartments and Their Influence on Metabolic Regulation III. Evidence for the Direct Transfer of Metabolite Among Enzymes via Enzyme-Enzyme Interactions IV. Molecular Inferences Regarding the Mechanism of Direct Transfer of Metabolites via Enzyme-Enzyme Interactions V. Further Consequences of the Direct Transfer Mechanism on Metabolic Pathways VI. Conclusions ReferencesThe Central Metabolic Pathways of Escherichia coli: Relationship Between Flux and Control at a Branch Point, Efficiency of Conversion to Biomass, and Excretion of Acetate I. Overview II. Flux of Carbon through the Central Metabolic Pathways III. Control of Flux at the Junction Created During Growth on Acetate IV. Excretion of Acetate and Conversion of Primary Carbon Source to Biomass ReferencesThe Concept of the Intracellular Amino Acid Pool and Its Relevance in the Regulation of Protein Metabolism, with Particular Reference to Mammalian Cells I. Introduction II. Intracellular Amino Acid Pools III. Uptake Features of Amino Acids into the Intracellular Pools IV. Pool Size and Composition V. A General Perspective of Intracellular Amino Acid Pool VI. Concluding Comments ReferencesProduction of Superoxide by Phagocytic Leukocytes: A Paradigm for Stimulus-Response Phenomena I. Introduction II. Overview of the Situation in Leukocytes III. Reduction of Oxygen by Phagocytic Leukocytes IV. Transmembrane Signaling V. Conclusions and Future Considerations ReferencesRegulation of Adrenergic Receptor Function by Phosphorylation I. Introduction II. Purification of Adrenergic Receptors III. Regulation of Responsiveness: The Model of Desensitization IV. Summary and Conclusions ReferencesControl of 5-Aminolevulinate Synthase in Animals I. Introduction II. ALV-Synthase and Heme Biosynthesis III. Mitochondrial and Cytosolic Forms of ALV-Synthase IV. Control of the Catalytic Activity of ALV-Synthase V. Transport of ALV-Synthase into Mitochondria VI. Control of the Level of Hepatic ALV-Synthase VII. Mechanism of Heme Depletion by Xenobiotics VIII. Erythroid ALV-Synthase and Its Control IX. ALV-Synthase Control in Other Tissues X. Porphyrias and ALV-Synthase XI. Summary ReferencesMeprin: A Membrane-Bound Metallo-Endopeptidase I. Introduction II. Molecular Properties and Cellular/Subcellular Distribution III. Heritable Deficiency of Meprin Activity in Mice IV. Physiological Significance of Meprin V. Conclusions ReferencesRegulation of Intracellular Protein Turnover: Covalent Modification as a Mechanism of Marking Proteins for Degradation I. Introduction II. Background III. Covalent Modification of Proteins as a First Step in the Degradation Process IV. Mixed-Function Oxidation of Proteins V. Characterization of a Nonlysosomal High-Molecular-Weight Cysteine Proteinase VI. Basis for Susceptibility to Proteolysis VII. Metabolic Control of Intracellular Protein Breakdown VIII. Is ATP Required for the Degradation of All Proteins? IX. Concluding Remarks ReferencesIndex