Current Topics in Cellular Regulation

ContributorsGTP: A Central Regulator of Cellular Anabolism I. Introduction II. In Vitro Studies of GTP Effects on Anabolic Processes III. Other Regulatory Activities of GTP IV. In Vivo Studies of GTP Effects V. Possible Role of GTP in Oncogenesis VI. The Stringent Response in Bacteria as an Anti-GTP Response VII. Similarities Among GTP-Binding Proteins VIII. Control of GTP Levels IX. General Discussion ReferencesA Quantitative Approach to Metabolic Control I. Introduction II. The Generation and Transmission of Metabolic Fluxes III. Quantitative Analysis of Regulation IV. Adenine Nucleotides as Regulators V. Regulatory Analysis of Branched Systems VI. Sensitivity and "Control Strength" VII. Calculations of the Response to a Large Change in Regulator Concentration VIII. Conclusions IX. Appendices ReferencesInactivation of Rabbit Liver and Muscle Aldolases by Limited Proteolysis by Lysosomal Cathepsin M I. Introduction II. Inactivation of Aldolase by Membrane-Bound Lysosomal Proteinases and by Undisrupted Lysosomes III. Purification of Cathepsin M and Comparison with Cathepsin B IV. Evidence for the Modification of Liver Aldolases by Cathepsin M in Vivo V. Regulation of Cathepsin M Activity VI. Concluding Remarks ReferencesThe Regulatory Functions of Proline and Pyrroline-5-carboxylic Acid I. Introduction II. Background III. The Metabolism of Pyrroline-5-Carboxylate IV. Redox Regulation and P5C Metabolism V. P5C as an Effector Molecule VI. The Proline-P5C Cycle VII. Implications of the P5C-Mediated Redox Regulation VIII. Summary and Perspectives ReferencesCharacteristics and Hormonal Regulation of Amino Acid Transport System A in Isolated Rat Hepatocytes I. Introduction II. General Characteristics of System A-Mediated Transport III. Hormonal Regulation of System A IV. Decay of Stimulated System A Activity V. Conclusions ReferencesIndexCumulative Contributors IndexContents of Recent Volumes