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Current Topics in Cellular Regulation, Volume 12 focuses on the binding of polypeptide hormones to the specific receptor sites on the cellular membrane. This book consists of six chapters. Chapter 1 describes how several polypeptide regulators, hormones, and growth factors act through very similar mechanisms. The second messenger roles of cAMP and cGMP in the regulation of various protein kinases are dealt with in Chapter 2. Chapter 3 discusses the experimental conditions employed in studying the characteristics of regulatory enzymes in vitro and in vivo, while Chapter 4 elaborates the intracellular compartmentation of enzymes, cofactors, and metabolic intermediates of glycolysis in various tissues from different organisms. The biochemical mechanisms that underlie the induction of enzymes in catabolic pathways are considered in Chapter 5. The last chapter is devoted to the role of T4 phage-induced covalent modification reactions in the transcriptional control of DNA-dependent RNA-polymerase in E. coli. This volume is suitable for biologists and researchers concerned with the basic mechanisms involved in the regulation of diverse cellular activities.
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-1-4832-1711-6 (9781483217116)
Schweitzer Classification
ContentsList of ContributorsPrefacePreface to Volume 12Hormone Receptors as Regulators of Hormone Action I. Introduction II. The Elements of the Hormonal Response III. Regulation of the Hormonal Response IV. Mechanism of the Hormonal Response V. Summary ReferencesSoluble Cyclic AMP-Dependent Protein Kinases: Review of the Enzyme Isolated from Bovine Cardiac Muscle I. Introduction II. Protein Kinases III. Bovine Cardiac Muscle Protein Kinase IV. Speculation ReferencesMetabolic Control and the Microenvironment I. Introduction II. Classical Concepts of Control III. Realities of the Microenvironment IV. A Case for New Concepts and Considerations V. Areas of Metabolism Influenced by Fructose Diphosphate VI. Concluding Remarks List of Abbreviations ReferencesThe Role of Compartmentation in the Control of Glycolysis I. Introduction II. Indirect Evidence of Localization III. Theoretical Considerations IV. Studies on Individual Enzymes of Glycolysis V. Compartmentation of Metabolites VI. Pyruvate VII. Compartmentation Between Organs in Complex Animals VIII. The Uncontrollability of Glycolysis List of Abbreviations ReferencesThe Evolution of Induction Mechanisms in Bacteria: Insights Derived from the Study of the ß-Ketoadipate Pathway I. Introduction II. Induction Mechanisms III. Origins of Regulatory Genes IV. The ß-Ketoadipate Pathway V. Economy of Enzyme Synthesis VI. Unified Induction VII. Genetic Origin of the ß-Ketoadipate Pathway VIII. Natural Selection of Induction Mechanisms IX. Origin and Selection of Product Induction X. Concluding Remarks ReferencesCovalent Structural Modification of DNA-Dependent RNA Polymerase as a Means for Transcriptional Control I. Introduction II. Two Different Covalent Structural Modifications of DNA-Dependent RNA Polymerase After Infection with Bacteriophage T4 III. Functional Differences Between Normal, T4-Altered, and T4-Modified E. coli RNA Polymerase IV. Conclusions ReferencesSubject IndexContents of Previous Volumes