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Current Topics in Cellular Regulation, Volume 11 focuses on the biochemical mechanisms and key role of the liver in the homeostasis of blood glucose. This book begins with a discussion of glucokinase that is known to play a key role in glucose uptake by liver, followed by a broad overview of the mechanisms that control both glucose uptake by and release from the liver and enzymes involved in glycogen synthesis and breakdown. The classical enzyme models for allosteric regulatory mechanisms known as the biodegradative threonine deaminase are also elaborated. Other topics include the control of blood cholesterol levels, use of cultured mammalian cells, and studies of mutant cell lines. A model for protein turnover is likewise presented, including other mechanisms for the selective degradation of protein, selective uptake by lysosomes, and possible role of stabilizing factors. This publication concludes with an evaluation of complex regulatory mechanisms proposed for the regulation of photosynthetic carbon assimilation. This volume is recommended for biologists and researchers interested in advances in the general area of cellular regulation.
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-1-4832-1710-9 (9781483217109)
Schweitzer Classification
ContentsList of ContributorsPrefacePreface to Volume 11ErratumRegulation of Glucokinase in Liver I. Introduction and History II. Localization in Hepatic Parenchymal Cells III. Dietary Regulation IV. Hormonal Regulation V. Embryonic Development VI. Phosphotransferase Activities of Glucose-6-Phosphatase VII. Glucokinase in Regenerating Liver VIII. Glucokinase in "Aged" Rats IX. Glucokinase in Extrahepatic Tissue X. Possible Mechanisms of Insulin Action on Glucokinase ReferencesThe Role of the Liver in the Homeostasis of Blood Glucose I. Introduction II. A Retrospect III. The Key Enzymes of Hepatic Glycogen Metabolism IV. The Converting Enzymes V. A Biochemical Translation of the Soskin Concept VI. Conclusions ReferencesRegulation of Biodegradative Threonine Deaminase I. Introduction II. Historical Background III. Reaction Mechanism IV. Subunit Structure V. Regulation of the Enzyme Activity VI. Regulation of the Enzyme Synthesis VII. Conclusion ReferencesThe LDL Pathway in Human Fibroblasts: A Receptor-Mediated Mechanism for the Regulation of Cholesterol Metabolism I. Background II. Delineation of the LDL Pathway in Human Fibroblasts III. Sequential Steps of the LDL Pathway IV. Overall Function of the LDL Pathway in Human Fibroblasts V. Feedback Regulation of the Activity of the LDL Receptor VI. The LDL Pathway in Other Cell Types in Tissue Culture VII. Unanswered Questions ReferencesMechanism and Regulation of Protein Turnover in Animal Cells I. Introduction II. A Model for Protein Turnover III. The Rate-Limiting Steps in Protein Turnover IV. Summary and Conclusions References Note Added in ProofRegulatory Mechanisms in Photosynthetic Carbon Metabolism I. Introduction II. Regulation of Catalysis III. Regulation by Mass Action IV. Regulation by Transport V. Regulation of Photorespiration VI. Flow Regulation VII. Conclusions ReferencesSubject IndexContents of Previous Volumes