Current Topics in Cellular Regulation

List of ContributorsPrefacePreface to Volume 8Contents of Previous VolumesA Molecular Model for Morphogenesis: The Primary Septum of Yeast I. The Biological Problem II. The Model III. The Enzymatic Mechanism of Chitin Synthesis IV. Intracellular Distribution of the Components of the Chitin Synthetase System V. A Working Hypothesis for Septum Initiation VI. Some Final Comments ReferencesMetabolic Regulation by Multifunctional Glucose-6-Phosphatase I. Introduction II. Multifunctionality and Other Characteristics of the Enzyme III. Is Phosphotransferase Activity of Glucose-6-Phosphatase of Physiological Significance? IV. Control of Hydrolytic and Synthetic Activities of Glucose-6-phosphatase-Phosphotransferase V. Some Proposed Physiological Regulatory Roles for Synthetic and Hydrolytic Activities of Glucose-6-phosphatase-Phosphotransferase VI. A Concluding Statement Appendix ReferencesGlutamine Synthetase as a Regulator of Enzyme Synthesis I. Introduction II. Genetics of Glutamine Synthetase III. Glutamine Synthetase as Repressor of Glutamate Dehydrogenase IV. Glutamine Synthetase as Activator of the Synthesis of Enzymes Forming Glutamate from Amino Acids V. Conclusions ReferencesAcetyl Coenzyme A Carboxylase I. Background II. Molecular Properties III. Mechanism of the Reaction and Prosthetic Group Translocation IV. Regulation of Catalytic Activity V. Concluding Remarks ReferencesRegulation of Lipogenesis in Animal Tissues I. Introduction II. Regulation of the Enzymes Involved in Fatty Acid Synthesis III. Regulation of Fatty Acid Esterification ReferencesDeamidation of Glutaminyl and Asparaginyl Residues in Peptides and Proteins I. Introduction II. Deamidation Half-Times of Glutaminyl and Asparaginyl Residues in Peptides III. Deamidation of Glutaminyl and Asparaginyl Residues in Proteins IV. Special Intramolecular and Intermolecular Effects V. Molecular Clocks VI. Summary ReferencesPasteur Effect and Phosphofructokinase I. Introduction II. Definition and Physiological Importance III. Methods for Demonstrating the Pasteur Effect IV. Inhibitors of the Pasteur Effect V. Mechanism of the Pasteur Effect VI. Phosphofructokinase as the Site of the Pasteur Effect VII. Properties of Phosphofructokinase and Their Relation to the Pasteur Effect in the Cell VIII. Analysis of the Multiplicity of Effectors of Phosphofructokinase IX. Systems in Which the Pasteur Effect Is Absent X. Molecular Properties of Phosphofructokinase and the Mechanism of Action of Effectors XI. Specificity of Effectors and Substrates of Phosphofructokinase XII. Sedoheptulose 7-Phosphate Kinase Activity of Phosphofructokinase XIII. Conclusions ReferencesSubject Index