Current Topics in Cellular Regulation

List of ContributorsPrefacePreface to Volume 6Contents of Previous VolumesRole of Proteases in Sporulation I. Introduction II. Extracellular Proteases of Bacilli III. Regulation of Extracellular Protease Synthesis and Sporulation IV. Protein Turnover during Sporulation V. The Modification of RNA Polymerase and Aldolase by a Serine Protease VI. Conclusions ReferencesRegulatory Properties of Glucose-6-Phosphate Dehydrogenase I. Introduction II. General Properties III. G6PD from Microorganisms IV. G6PD from Mammalian Cells V. Concluding Remarks ReferencesThe Behavior of Intact Biochemical Control Systems I. Introduction II. Essential Concepts and Techniques Illustrated by the Analysis of a Simple System III. Natural Selection of Feedback Inhibition Patterns in Biosynthetic Pathways IV. On the Significance of Feedforward Inhibition in a Biosynthetic Pathway V. Cascaded Enzymatic Mechanisms VI. Summary ReferencesA Possible Role for Kinetic Reaction Mechanism Dependent Substrate and Product Effects in Enzyme Regulation I. Introduction II. Product Effects on Enzyme Velocity Responses III. Product Effects on Cooperative Substrate Binding IV. Substrate Effects on Enzyme Velocity Responses V. Simulations and Observations with Actual Systems VI. Michaelis Constants VII. Evaluation and Future Developments ReferencesControl of Biogenesis of Isoprenoid Compounds in Animals I. The Pathways of Biogenesis II. Cholesterol III. Ubiquinone IV. Bile Acids V. Steroid Hormones VI. Concluding Remarks ReferencesOn Allosteric Models I. Some General Relations II. A Parent Model III. The MWC and Induced-Fit Models as Subcases IV. The Effect of a Second Ligand V. The Effect of Subunit Heterogeneity VI. An Example from Trout Hemoglobin VII. Conclusion ReferencesRegulation of Uridylic Acid Biosynthesis in Eukaryotic Cells I. General Pathway for Uridylic Acid Biosynthesis II. Genetic Control of Enzyme Levels in Fungi III. The Eukaryotic Enzymes ReferencesFlip-Flop Mechanisms and Half-Site Enzymes I. Introduction II. The Flip-Flop Mechanism. Description of a Model, the Alkaline Phosphatase of Eschenchia coli III. Half-Site Enzymes IV. Half-of-the-Sites Reactivity and Flip-Flop Mechanisms for Allosteric Enzymes V. The Functional and Evolutionary Advantages of Half-Site Enzymes and Flip-Flop Mechanisms References Note Added in ProofAuthor IndexSubject Index