Current Topics in Cellular Regulation

List of ContributorsPrefaceContents of Previous VolumesPhosphofructokinase I. Introduction-The Discovery of the Regulatory Role of Phosphofructokinase II. Molecular Structure and Association-Dissociation Systems III. Allosteric Kinetics IV. Nature of Allosteric Control V. Identification of Functional Groups in the Enzyme VI. Mechanism of the Reaction VII. Physiological Interpretation of Phosphofructokinase Regulation VIII. Complementarity in Enzyme Regulation IX. Conclusion ReferencesA Theoretical Background to the Use of Measured Concentrations of Intermediates in Study of the Control of Intermediary Metabolism I. Introduction II. Theoretical Background to the Study of Intermediary Metabolism and a General Approach III. The Crossover Theorem IV. Application of the Principles Developed ReferencesMemory Molecules I. Introduction II. Historical Review: Approaches Used by Chemists, Anatomists, Pharmacologists, and Neurophysiologists III. In Search of the Engram IV. Nucleoproteins Increased with Brain Activity V. RNA as the Memory Molecule VI. Short-Term and Long-Term Memory: Proteins for Coding? VII. Interanimal Transfer of Acquired Information VIII. Scotophobin: First Deciphered Word of a New Biological Code? IX. A Theory for the Mode of Action of Memory Peptides X. Conclusion ReferencesProtein Kinases I. Introduction II. General Aspects III. Protein Kinases and the Regulation of Glycogen Metabolism IV. Cyclic AMP-Dependent Protein Kinases V. Protein Kinases and the Regulation of Lipid Metabolism VI. Protein Kinases and the Regulation of Nuclear Activity VII. The Regulation of Adrenal Steroid Production VIII. Protein Kinases and the Regulation of Pyruvic Dehydrogenase IX. Protein Kinases and the Regulation of Other Systems ReferencesGlutamine Phosphoribosylpyrophosphate Amidotransferase I. Introduction II. Kinetics and Mechanism of Action III. Structure IV. Regulation of Activity V. Enzyme Induction, Derepression, and Repression VI. Summary ReferencesThe Regulatory Influence of Allosteric Effectors on Deoxycytidylate Deaminases I. Introduction II. Feedback Regulation of Deoxycytidylate Deaminase III. Allosteric Transitions Effected by the Regulatory Ligands IV. Active and Inactive States Associated with Deoxycytidylate Deaminase V. Use of Inhibitors to Define the Physiological Significance of Deoxycytidylate Deaminase VI. Distribution and Role Deoxycytidylate Deaminase in Bacterial Systems VII. Regulatory Responses of the Bacteriophage-Induced Deoxycytidylate Deaminases to Its Metabolic End Products VIII. Physical and Chemical Properties of the T2r* Bacteriophage-Induced Deoxycytidylate Deaminase IX. The Effect of pH on the Allosteric Response of Deoxycytidylate Deaminase X. Studies on the in Vitro Synthesis of Bacteriophage-Induced Deoxycytidylate Deaminase IX . Conclusion ReferencesThe Citrate Enzymes: Their Structures. Mechanisms. and Biological Functions I. Introduction II. Citrate Lyase (Citritase) III. Citrate Synthase IV. ATP Citrate Lyase (Citrate Cleavage Enzyme) V. Overview ReferencesRegulation of Histidine Biosynthesis in Salmonella typhimurium I. Introduction II. The Enzymes of Histidine Biosynthesis III. The Operon IV. Feedback Inhibition V. Repression VI. Other Possible Mechanisms of Regulation ReferencesAuthor IndexSubject Index