Textbook of Diabetes

Preface to the Fourth Edition, xiii

Foreword, xv

List of Abbreviations, xvi

Part 1 Diabetes in its Historical and Social Context

1 The History of Diabetes Mellitus, 3
Robert B. Tattersall

2 The Classifi cation and Diagnosis of Diabetes, 24
K. George M.M. Alberti

3 Epidemiology of Type 1 Diabetes, 31
Lars C. Stene, Valma Harjutsalo, Elena Moltchanova & Jaakko Tuomilehto

4 Epidemiology of Type 2 Diabetes, 45
Ronald C.W. Ma & Peter C.Y. Tong

5 The Global Burden of Diabetes, 69
Mohammed K. Ali, Mary Beth Weber & K.M. Venkat Narayan

Part 2 Normal Physiology

6 Islet Function and Insulin Secretion, 87
Peter M. Jones & Shanta J. Persaud

7 Insulin Action, 104
Xuxia Wu & W. Timothy Garvey

8 Control of Weight: How Do We Get Fat? 126
George A. Bray

Part 3 Pathogenesis of Diabetes

9 Type 1 Diabetes, 141

Autoimmune Type 1 Diabetes, 141
Ahmed J. Delli, Helena Elding Larsson, Sten-A. Ivarsson & Åke Lernmark

Other Disorders with Type 1 Phenotype, 152
Alice P.S. Kong & Juliana C.N. Chan

10 Abnormalities of Insulin Secretion and -Cell Defects in Type 2 Diabetes, 160
Mazen Alsahli & John E. Gerich

11 Insulin Resistance in Type 2 Diabetes, 174
Hannele Yki-Järvinen

12 The Genetics of Type 2 Diabetes: From Candidate Gene Biology to Genome-Wide Studies, 191
Martine Vaxillaire & Philippe Froguel

13 Metabolic Disturbances in Diabetes, 215
Adrian Vella & Robert A. Rizza

14 Obesity and Diabetes, 227
Hans Hauner

Part 4 Other Types of Diabetes

15 Monogenic Causes of Diabetes, 245
Angus Jones & Andrew T. Hattersley

16 Drug-Induced Diabetes, 265
Neil J.L. Gittoes, John Ayuk & Robin E. Ferner

17 Endocrine Disorders that Cause Diabetes, 279
Neil A. Hanley

18 Pancreatic Diseases and Diabetes, 298
Ranjit Unnikrishnan & Viswanathan Mohan

Part 5 Managing the Patient with Diabetes

19 Clinical Presentations of Diabetes, 313
Ee Lin Lim & Roy Taylor

20 The Aims of Diabetes Care, 323
Richard I.G. Holt & Barry J. Goldstein

21 Educating the Patient with Diabetes, 334
Carolé Mensing & Barbara Eichorst

22 Lifestyle Issues: Diet, 346
Monika Toeller

23 Lifestyle Issues: Exercise, 358
Jane E. Yardley, Angela Alberga, Glen P. Kenny & Ronald J. Sigal

24 Social Aspects of Diabetes, 380
Brian M. Frier & Mark W.J. Strachan

25 Monitoring Diabetes, 399
Andrew J. Farmer

26 Drug Therapy: Special Considerations in Diabetes, 410
Bernard M.Y. Cheung & Robin E. Ferner

Part 6 Treatment of Diabetes

27 Insulin and Insulin Treatment, 427
Stephen Gough & Parth Narendran

28 New Technologies for Insulin Administration and Glucose Monitoring, 440
Howard Wolpert & Judy Shih

29 Oral Antidiabetic Agents, 452
Clifford J. Bailey & Andrew J. Krentz

30 Non-Insulin Parenteral Therapies, 478
Jens Juul Holst, Sten Madsbad & Ole Schmitz

31 How to Use Type 2 Diabetes Treatments in Clinical Practice: Combination Therapies, 494
Joseph A. Aloi & Anthony L. McCall

32 In-Hospital Treatment and Surgery in Patients with Diabetes, 514
Maggie Sinclair Hammersley & June James

33 Hypoglycemia in Diabetes, 528
Philip E. Cryer

34 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and Hyperosmolar Hyperglycemia, 546
Troels Krarup Hansen & Niels Møller

Part 7 Microvascular Complications in Diabetes

35 Pathogenesis of Microvascular Complications, 555
Ferdinando Giacco & Michael Brownlee

36 Diabetic Retinopathy, 575
Peter H. Scanlon

37 Diabetic Nephropathy, 599
Sally M. Marshall & Allan Flyvbjerg

38 Diabetic Peripheral Neuropathy, 615
Dan Ziegler

Part 8 Macrovascular Complications in Diabetes

39 The Pathogenesis of Macrovascular Complications Including Atherosclerosis in Diabetes, 637
Riccardo Candido, Mark E. Cooper & Karin A.M. Jandeleit-Dahm

40 Cardiovascular Risk Factors, 657

Hypertension, 657
Peter M. Nilsson

Dyslipidemia: Diabetes Lipid Therapies, 672
Adie Viljoen & Anthony S. Wierzbicki

41 Congestive Heart Failure, 684
Inga S. Thrainsdottir & Lars Rydén

42 Cerebrovascular Disease, 698
Colum F. Amory & Jesse Weinberger

43 Peripheral Vascular Disease, 710
Henrik H. Sillesen

Part 9 Other Complications of Diabetes

44 Foot Problems in Patients with Diabetes, 727
Andrew J.M. Boulton

45 Sexual Function in Men and Woman with Diabetes, 743
David Price

46 Gastrointestinal Manifestations of Diabetes, 760
Adil E. Bharucha & Michael Camilleri

47 The Skin in Diabetes, 774
Graham R. Sharpe & Paul D. Yesudian

48 Bone and Rheumatic Disorders in Diabetes, 789
Andrew Grey & Nicola Dalbeth

49 Psychologic Factors and Diabetes, 807
Christopher M. Ryan

50 Diabetes and Infections, 835
Clive S. Cockram & Nelson Lee

Part 10 Diabetes in Special Groups

51 Diabetes in Childhood, 859
Christine Chan & Marian Rewers

52 Diabetes in Adolescence and Transitional Care, 875
Debbie Kralik & Maria Kambourakis

53 Diabetes in Pregnancy, 888
Anne Dornhorst & Anita Banerjee

54 Diabetes in Old Age, 922
Alan J. Sinclair

55 Psychiatric Disorders and Diabetes, 940
Robert C. Peveler & Richard I.G. Holt

Part 11 Delivery and Organization of Diabetes Care

56 The Role of Community and Specialist Services, 959
Jane Overland, Margaret McGill & Dennis K. Yue

57 The Role of the Multidisciplinary Team, 969
Wing-Yee So & Juliana C.N. Chan

58 Models of Diabetes Care Across Different Resource Settings, 984
Naomi S. Levitt, Bob Mash, Nigel Unwin, Jean Claude Mbanya, Jae-Hyoung Cho & Kun-Ho Yoon

Part 12 Future Directions

59 Future Drug Treatment for Type 1 Diabetes, 1001
Helena Elding Larsson, Ahmed J. Delli, Sten-A. Ivarsson & Åke Lernmark

60 Future Drug Treatments for Type 2 Diabetes, 1017
Clifford J. Bailey

61 Other Future Directions, 1045

Stem Cell Therapy in Diabetes, 1045
Shuibing Chen, Jayaraj Rajagopal, Qiao Zhou & Douglas A. Melton

Islet Transplantation, 1050
Angela Koh, Peter Senior & A.M. James Shapiro

Gene Therapy, 1064
Andreea R. Barbu & Nils Welsh

62 Future Models of Diabetes Care, 1070
Robert A. Gabbay & Alan M. Adelman

Index, 1081