Current Topics in Membranes and Transport

Name: Current Topics in Membranes and Transport
Brand: Academic Press
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Joseph F. Hoffman Bliss Forbush(Author)

Academic Press

Published on 1. September 1983

1042 pages

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978-0-08-058490-4 (ISBN)

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Front Cover
Structure, Mechanism, and Function of the Na/K Pump, Volume 19
Copyright Page
Contents
List of Contributors
Preface
Acknowledgments
Yale Membrane Transport Processes Volumes
Contents of Previous Volumes
PART I: THERMODYNAMIC ASPECTS OF MEMBRANE TRANSPORT
Chapter 1. What Is a Coupled Vectorial Process?
Chapter 2. The Membrane Equilibrium with Chemical Reactions
PART II: STRUCTURAL ANALYSIS OF Na,K-ATPase
Chapter 3. Structural Aspects of Na,K-ATPase
Chapter 4. Detergent Solubilization of Na,K-ATPase
Chapter 5. Methods for the Cleavage of the Large Subunit of Na,K-ATPase and the Resolution of the Peptides Produced
Chapter 6. Selective Purification of Na,K-ATPase and Ca2+, Mg2+-ATPase from Eel Electroplax
Chapter 7. High-Performance Gel Chromatography of Horse Kidney Na,K-ATPase
Chapter 8. Native Membranes from Dog Kidney Outer Medulla, Enriched in Na,K-ATPase, and Vesicular in Nature
Chapter 9. Ultrastructure of Na,K-ATPase in Plasma Membranes Vesicles
Chapter 10. Electron Microscope Analysis of Two-Dimensional Crystals of Membrane-Bound Na,K-ATPase
Chapter 11. Organization of the Transmembrane Segments of Na,K-ATPase. Labeling of Lipid Embedded and Surface Domains of the a-Subunit and Its Tryptic Fragments with [125l] lodonaphthylazide, [32P]ATP, and Photolabeled Ouabain
Chapter 12. Structural Studies on Lamb Kidney Na,K-ATPase
Chapter 13. Two Slightly Different a-Subunit Components of Kidney Na,K-ATPase Induced by Heat Treatment
Chapter 14. Radiation Inactivation Analysis of Na,K-ATPase
Chapter 15. Stoichiometrical Binding of Ligands to Less than 160 Kilodaltons of Na,K-ATPase
Chapter 16. The Active Site Structure of Na,K-ATPase: Location of a Specific Fluorescein Isothiocyanate-Reactive Site
Chapter 17. Subunit Distribution of Sulfhydryl Groups and Disulfide Bonds in Rena Na,K-ATPase
Chapter 18. Lipid Regions of Na,K-ATPase Examined with Fluorescent Lipid Probes
Chapter 19. Role of Cholesterol and Other Neutral Lipids in Na,K-ATPase
PART III: LIGAND INTERACTIONS: CARDIAC GLYCOSIDES AND IONS
Chapter 20. Cardiotonic Steroid Binding to Na,K-ATPase
Chapter 21. Binding of Monovalent Cations to the Na,K-ATPase
Chapter 22. Half-of-the-Sites Reactivity of Na,K-ATPase Examined by the Accessibility of Vanadate and ATP into Enzyme-Ouabain Complexes
Chapter 23. Binding of Rb+ and ADP to a Potassium-Like Form of Na,K-ATPase
Chapter 24. Side-Dependent Ion Effects on the Rate of Ouabain Binding to Reconstituted Human Red Ceii Ghosts
Chapter 25. Intracellular Sodium Enhancement of Ouabain Binding to Na,K-ATPase and the Development of Glycoside Actions
Chapter 26. Lithium-Catalyzed Ouabain Binding to Canine Kidney Na,K-ATPase
Chapter 27. Ouabain Binding and Na,K-ATPase in Resealed Human Red Cell Ghosts
Chapter 28. Stereoelectronic Interaction between Cardiotonic Steroids and Na,K-ATPase: Molecular Mechanism of Digitalis Action
Chapter 29. Use of Prophet and MMS-X Computer Graphics in the Study of the Cardiac Steroid Receptor Site of Na,K-ATPase
Chapter 30. Photoaffinity Labeling of the Ouabain Binding Site of Na,K-ATPase
Chapter 31. New Ouabain Derivatives to Covalently Label the Digitalis Binding Site
Chapter 32. Ouabain Sensitivity: Diversity and Disparities
PART IV: LIGAND INTERACTIONS: NUCLEOTIDES, VANADATE, AND PHOSPHORYLATION
Chapter 33. Ligand Interactions with the Substrate Site of Na,K-ATPase: Nucleotides, Vanadate, and Phosphotylation
Chapter 34. Conformational Changes of Na,K-ATPase Necessary for Transport
Chapter 35. On the Mechanism behind the Ability of Na,K-ATPase to Discriminate between Na+ and K+
Chapter 36. Characteristics of the Electric Eel Na,K-ATPase Phosphoprotein
Chapter 37. Sulfhydryl Groups of Na,K-ATPase: Effects of N-Ethylmaleimide on Phosphorylation from ATP in the Presence of Na+ + Mg2+
Chapter 38. Alternative Pathways of Phosphorylation of Na,K-ATPase Regulated by Na+ Ions on Both Sides of the Plasma Membrane
Chapter 39. Structurally Different Nucleotide Binding Sites in Na,K-ATPase
Chapter 40. Study of Na,K-ATPase with ATP Analogs
Chapter 41. Affinity Labeling Studies of the ATP Binding Site of Canine Kidney Na,K-ATPase
Chapter 42. 31P[18Ol NMR Kinetic Analysis of 18O Exchange Reaction between Pi and H2O Catalyzed by Na,K-ATPase
PART V: CONFORMATIONAL CHANGES, STRUCTURE/FUNCTION, AND ACTIVE SITE PROBES
Chapter 43. Principal Conformations of the a-Subunit and Ion Translocation
Chapter 44. Magnesium-Induced Conformational Changes in Na,K-ATPase
Chapter 45. Rubidium Movements in Vesicles Reconstituted with Na,K-ATPase, Measured in the Absence of ATP and Pi, in the Presence of Either Ligand, and in the Presence of Both Ligands: Role of the "Occluded State" in Allowing for the Control of the Direction of Ion Movements
Chapter 46. Eosin: A Fluorescent Probe of ATP Binding to Na,K-ATPase
Chapter 47. Interaction of Divalent Cations with Fluorescein-Labeled Na,K-ATPase
Chapter 48. Cation Activation of Na,K-ATPase after Treatment with Thimerosal
Chapter 49. Alteration of Conformational Equilibria in Na,K-ATPase by Glutaraldehyde Treatment
Chapter 50. Conformational Transition between ADP-Sensitive Phosphoenzyme and Potassium- Sensitive Phosphoenzyme
Chapter 51. Relation between Red Cell Membrane Na,K-ATPase and Band 3
PART VI: REACTION MECHANISM AND KINETIC ANALYSIS
Chapter 52. Kinetic Analyses and the Reaction Mechanism of the Na,K-ATPase
Chapter 53. Evidence for Parallel Pathways of Phosphoenzyme Formation in the Mechanism of ATP Hydrolysis by Electrophorous Na,K-ATPase
Chapter 54. Evaluation of the Reaction Mechanism of the Sodium Pump by Steady-State Kinetics
Chapter 55. Kinetic Evidence in Favor of a Consecutive Model of the Sodium Pump
Chapter 56. Kinetic Models of Na-Dependent Phosphorylation of Na,K-ATPase from Rat Brain
Chapter 57. Reinvestigation of the Sequence of Sensitivity of Phosphoenzyme of Na,K-ATPase to ADP and K+ during the Presteady State of the Phosphorylation by ATP
Chapter 58. Interaction of Na+, K+, and ATP with Na,K-ATPase
Chapter 59. Sodium Ion Discharge from Pig Kidney Na,K-ATPase
Chapter 60. ADP Sensitivity of the Native and Oligomycin-Treated Na,K-ATPase
Chapter 61. Three (at Least) Consecutive Phosphointermediates of Na-ATPase
Chapter 62. Aspects of the Presteady State Hydrolysis of ATP by Na,K-ATPase
Chapter 63. Identity of the Na Activation Sites in ATPase wlth the K Activation Sites in p-Nitrophenylphosphatase
Chapter 64. On the Existence of Two Distinct Hydrolysis Cycles for Na,K-ATPase with Only One Active Substrate Site
Chapter 65. Kinetic Analysis of the Effects of Na+ and K+ on Na,K-ATPase
Chapter 66. Divalent Cations and Conformational States of Na,K-ATPase
PART VII: ION TRANSLOCATION AND REACTION MECHANISM
Chapter 67. Na,K-ATPase: Reaction Mechanisms and lon Translocating Steps
Chapter 68. Existence and Role of Occluded-Ion Forms of Na,K-ATPase
Chapter 69. Na and K Fluxes Medlated by ATP-Free and ATP-Activated Na,K-ATPase in Liposomes
Chapter 70. Sidedness of Cations and ATP Interactions with the Sodium Pump
Chapter 71. Sidedness of Sodium lnteractions with the Sodlum Pump in the Absence of K+
Chapter 72. Magnesium Dependence of Sodium Pump Mediated Sodium Transport in Intact Human Red Ceils
Chapter 73. K+-Independent Active Transport of Na+ by Na,K-ATPase
Chapter 74. ADP-ATP Exchange in Internally Dialyzed Squid Giant Axons
Chapter 75. Sodium Pump-Catalyzed ATP-ADP Exchange In Red Blood Cells: The Effects of lntracellular and Extracellular Na and K Ions
Chapter 76. Ouabain-Sensitive ATP-ADP Exchange and Na-ATPase of Resealed Red Cell Ghosts
Chapter 77. Effect of Internal Adenine Nucieotides on Sodium Pump-Catalyzed Na-Na and Na-K Exchanges
Chapter 78. Na/K Pump in Inside-out Vesicles Utilizing ATP Synthesized at the Membrane
Chapter 79. Anion-Coupled Na Efflux Mediated by the NalK Pump in Human Red Blood Cells
Chapter 80. Effect of Trypdn Digestion on the Kinetlc Behavior of the NalK Pump in Intact Erythrocytes
Chapter 81. Sodium Movement and ATP Hydrolysis in Basolateral Plasma Membrane Vesicles from Proximal Tubular Cells of Rat Kidney
Chapter 82. Stoichiometry of the Electrogenic Na Pump in Barnacle Muscle: Simultaneous Measurement of Na Efflux and Membrane Current
PART VIII: BIOSYNTHESIS, MULTIPLE FORMS, AND IMMUNOLOGY
Chapter 83. Regulation of Na,K-ATPase by Its Biosynthesis and Turnover
Chapter 84. Biosynthesis of Na,K-ATPase in MDCK Cells
Chapter 85. Possible Functional Differences between the Two Na,K-ATPases of the Brain
Chapter 86. Antigenic Properties of the a-,ß-, and ?-Subunits of Na,K-ATPase
Chapter 87. Antibodies to Na,K-ATPese: Characterization and Use in Cell-Free Synthesis Studies
Chapter 88. lmmunoreactivity of the a- and a( +)-Subunits of Na,K-ATPase in Different Organs and Species
Chapter 89. Role of Na+ and Ca2+ Fluxes in Terminal Differentiation of Murine Erythroleukemia Cells
Chapter 90. Na/K Pumps and Passive K+ Transport in Large and Small Reticulocytes of Anemic Low- and High-Potassium Sheep
Chapter 91. Enhancement of Biosynthesis of Na,K-ATPase in the Toad Urinary Bladder by Aldosterone But Not T3
Chapter 92. Na,K-ATPase Activity in Rat Nephron Segments: Effect of Low-Potassium Diet and Thyroid Deficiency
Chapter 93. Axonal Transport of Na,K-ATPase in Optic Nerve of Hamster
PART IX: Na,K-ATPase AND POSITIVE INOTROPY
ENDOGENOUS GLYCOSIDES
Chapter 94. Positive lnotropic Action of Digitalis and Endogenous Factors: Na,K-ATPase and Posltive Inotropy
"Endogenous Glycosides"
Chapter 95. Endogenous Glycoside-Like Substances
Chapter 96. Monovalent Cation Transport and Mechanisms of Digltalis-Induced Inotropy
Chapter 97. Effects of Sodium Pump Inhibition on Contraction in Sheep Cardiac Purkinje Fibers
Chapter 98. Quantitative Evaluation of [3H]Ouabain Binding to Contracting Heart Muscle, Positive Inotropy, Na,K-ATPase Inhibition, and 86Rb+ Uptake in Several Species
Chapter 99. Contractile Force Effects of Low Concentrations of Ouabain in Isolated Guinea Pig, Rabbit, Cat, and Rat Atria and Ventricles
Chapter 100. Difference of Digitalis Binding to Na,K-ATPase and Sarcolemma Membranes
Chapter 101. Pharmacological and Biochemical Studies on the Digitalis Receptor: A Two-Site Hypothesis for Positive lnotropic Action
Chapter 102. Hypothesis for the Mechanism of Stimulation of the NdK Pump by Cardiac Glycosides-Role of Endogenous Digitalis-Like Factor
Chapter 103. lmmunochemical Approaches to the Isolation of an Endogenous Digoxin-like Factor
Chapter 104. Demonstration of a Humoral Na/K Pump lnhlbitor in Experimental Low-Renin Hypertension
Chapter 105. Absence of Ouabain-Like Activity of the Na,K-ATPase Inhibitor in Guinea Pig Brain Extract
Chapter 106. Brain Na,K-ATPase: Regulation by Norepinephrine and an Endogenous Inhibitor
Chapter 107. Inhibitory and Stimulatory Effects of Vanadate on Sodium Pump of Cultured Heart Cells from Different Species
Chapter 108. Endogenous Inhibitor of Na,K-ATPase: "Endodigin"
PART X: PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE Na/K PUMP
Chapter 109. Disorders in Molecular Assemblies for Na Transport in Essential Hypertension
Chapter 110. The Na-K Cotransport System in Essential Hypertension
Chapter 111. Loss of Na,K-ATPase Activity during Cataract Formation in Lens
Chapter 112. Na/K Pump: Effect of Obesity and Nutritional State
Chapter 113. Decreased Na,K-ATPase Activity in Erythrocyte Membranes and Intact Erythrocytes from ObeseMan
Chapter 114. Functionally Abnormal Na/K Pump in Erythrocytes from a Morbidly Obese Subject
Chapter 115. Specific Insulin Binding to Purified Na,K-ATPase Associated with Rapid Activation of the Enzyme
Chapter 116. A Mechanism for Cholinergic Stimulation of Sodium Pump in Rat Submandibular Gland
Chapter 117. Evidence for an Aldosterone-Mediated, Na-Dependent Activation of Na,K-ATPase in the Cortical Collecting Tubule
Chapter 118. Vanadate and Somatostatin Having Divergent Effects on Pancreatic Islet Na,K-ATPase
Chapter 119. Phosphorylation of a Kidney Preparation of Na,K-ATPase by the Catalytic Subunit of CAMP-Dependent Protein Kinase
Chapter 120. Modulation of Na,K-ATPase Activity in Rat Brain by Adenosine 3' ,5' -Monophosphate
Chapter 121. Stimulation and Inhibition by Plasma of Ouabain-Sensitive Sodium Efflux in Human Red Blood Cells
Chapter 122. Inhibition of the Na Pump by Cytoplasmic Calcium in Intact Red Cells
Chapter 123. Involvement of Calmodulin in the Inhibition of Na,K-ATPase by Ouabain
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Current Topics in Membranes and Transport

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