The Multi-Organ Donor: A Guide to Selection, Preservation and Procurement
1st Edition
Published on 29. November 2018
215 pages
978-1-68108-756-6 (ISBN)
Description
Advances in the science of immunology have improved the success rate of organ transplantations since the mid twentieth century. Organ transplantation is now a lifesaving medical procedure for thousands of patients around the world with end-organ diseases.
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Juan A. Sanchez | Robert S. D. Higgins
The Multi-Organ Donor
A Guide to Selection, Preservation and Procurement
Book
11/2018
Bentham Science Publishers
€152.99
Shipment within 3-4 weeks
Content
- Cover
- Title
- Biblography
- End User License Agreement
- Contents
- Preface
- List of Contributors
- Introduction
- Juan A. Sanchez and Robert S.D. Higgins*
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- The Organ Allocation System
- Karen Kennedy* and Charles Alexander
- INTRODUCTION
- Legislative, Regulatory and Accreditation History Highlights
- Uniform Anatomical Gift Act
- Organ Procurement Organization Accreditation Program
- Organ Donor Clinical Processes
- Referral and Evaluation
- Authorization Processes
- Clinical Donor Management
- Donor Management Priorities
- Organ Allocation Overview
- Heart and Lung Wait Lists and Allocation: Excerpts from UNOS Policies 6, 10 [2]
- Liver Wait List and Allocation: Excerpts from UNOS Policy 9 [2]
- Intestine Allocation Algorithm: Excerpts from UNOS Policy 7 [2]
- Geographic Location [2]
- Medical Urgency [2]
- Additional Considerations
- Kidney Wait List and Allocation: Excerpts from UNOS Policy 8 [2]
- KDPI Score [2]
- EPTS Score [2]
- CPRA Percentage [2]
- KAS System [2]
- Kidney Allocation Points Score [2]
- Antigen Mismatch [2]
- Geographic Proximity
- Double Kidney Allocation [2]
- Pancreas Wait List and Allocation: Excerpts from UNOS Policy 11 [2]
- CPRA Percentage [2]
- Antigen Mismatch [2]
- Geographic Proximity and Waiting Time
- Kidney - Pancreas Allocation: Excerpts from UNOS Policy 11 [2]
- ABO
- VCA Wait List and Allocation: Excerpts from UNOS Policy 12 [2]
- Surgical Recovery Processes
- Follow-up Activities
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Identification of the Brain Dead Donor
- Justin Zamoyski and Diana Greene-Chandos*
- INTRODUCTION
- PATHOLOGY AND PHYSIOLOGY
- PREPARATION FOR CLINICAL EXAM
- Coma
- Neuroimaging Correlates
- Sedation Absent
- Paralytic Absent
- Absence of Metabolic Abnormalities
- Normothermia
- Normotension
- Absence of Spontaneous Respirations
- COMPONENTS OF BRAIN DEATH EXAMINATION
- Pupillary Reflexes
- Corneal Reflexes
- Oculocephalic Reflex
- Oculovestibular Reflex
- Facial Noxious Stimuli
- Pharyngeal and Tracheal Reflexes
- Noxious Stimuli in Extremities
- APNEA TESTING
- ANCILLARY TESTING
- Electrophysiological Testing
- Vascular Imaging
- SPECIAL CIRCUMSTANCES
- Pediatric Patients
- "Brainstem" Death
- Maternal Death by Neurological Criteria
- Religious Exceptions
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Management of Public Health Service (PHS) Increased Risk Donors and Hepatitis C or HIV Infected Donors
- Nicole Theodoropoulos*, 1, Stephanie Pouch2 and Dorry Segev3
- INTRODUCTION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Management of the Multi-Organ Donor and Logistic Considerations
- Sharon Weeks*, Shane Ottmann and Andrew Cameron
- INTRODUCTION
- DONOR MANAGEMENT
- Cardiovascular Dysfunction
- Pulmonary Deterioration
- Endocrine Derangements
- Temperature Regulation
- LOGISTIC CONSIDERATIONS
- Organizational Considerations
- Logistics of Organ Recovery
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Current State of Organ Preservation
- Eliza Beal, Bryan Whitson* and Sylvester Black
- INTRODUCTION
- Preservation Solutions
- Classification of Preservation Solutions
- Intracellular Vs. Extracellular Solutions
- Impermeants
- Antioxidants
- Buffers
- Energy Precursors
- Abdominal Transplant
- Liver Preservation
- Renal Preservation
- Pancreas Preservation
- Intestinal Preservation
- Cardiac and Pulmonary Transplant
- Heart Transplantation
- Lung Transplantation
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Organ Specific Considerations: Heart
- Vincent Nardy1, Ahmet Kilic2,* and Arman Kilic3
- INTRODUCTION
- Donor and Recipient Selection
- Patient Management and Preservation Strategies
- Procurement Technique
- FUTURE DIRECTIONS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Organ Specific Considerations: Lung
- Jinny Ha, Stephen Broderick and Errol Bush*
- INTRODUCTION
- Donor Criteria
- Age
- Smoking History
- ABO Compatibility
- Size Criteria
- Graft Ischemia
- Radiographic Findings
- Bronchoscopy and Gram Stain
- Gas Exchange
- Techniques for Donor Lung Extraction
- Initial On-site Evaluation of the Donor Organ
- Positioning
- Initial Gross Evaluation of the Donor Lungs
- Donor Lung Dissection
- Donor Lung Excision
- CONCLUSIONS AND FUTURE DIRECTIONS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Liver Procurement: The Donor Hepatectomy
- Marcos E. Pozo, Russell Wesson, Benjamin Philosophe, Andrew Cameron* and Jacqueline Garonzik-Wang
- INTRODUCTION
- General Considerations
- Technique for Liver Procurement
- Before Incision
- Warm Dissection
- Organ Cold Perfusion
- Cold Dissection
- Special Scenarios
- Unexpected Intraabdominal Findings
- Alternative Cannulation and Cross-Clamp Sites
- Donation after Cardiac Death (DCD)
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Organ Specific Considerations: Pancreas and Kidney
- Iyore James, Ashraf El-Hinnawi and Amer Rajab*
- INTRODUCTION
- Donor Selection [Pancreas]
- Donor Selection [Kidney]
- Procurement
- Preservation
- CONCLUSION/FUTURE DIRECTION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Living Donation
- Ben Philosophe1, Jaime Glorioso1, Shane Ottmann1, Iyore James1 and Amer Rajab*, 2
- INTRODUCTION
- Living Donor Liver Transplantation (LDLT)
- Patient Selection
- Surgical Technique
- Donor Right Lobe Hepatectomy
- Donor Left Lobe Hepatectomy
- Donor Left Lateral Hepatectomy
- LIVING DONATION- KIDNEY
- Introduction
- Benefits of Living Donor Kidney Transplant
- Donor Evaluation
- Operative Approach
- Complications
- CONCLUDING REMARKS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Pediatric Issues: Split Liver/Living Liver Donation
- Kyle Jackson, Benjamin Philosophe and Andrew Cameron*
- INTRODUCTION
- SPLIT LIVER TRANSPLANTATION
- Introduction
- Technical Aspects
- Donor and Recipient Selection
- Potential Complications and Issues
- Modern Outcomes
- LIVING DONOR LIVER TRANSPLANTATION
- Introduction
- Donor Issues
- Technical Issues
- Potential Complications and Issues
- Modern Outcomes
- SUMMARY
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Islet Cell Donation
- Jill Buss and Amer Rajab*
- INTRODUCTION
- Donor Characteristics
- Donor Scoring
- Organ Procurement
- Organ Preservation
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- The Future of Organ Donation: Ex Vivo Preservation
- Eliza Beal, Sylvester Black and Bryan Whitson*
- INTRODUCTION
- Ex Vivo Liver Perfusion
- Hypothermic Machine Perfusion
- Subnormothermic Perfusion
- Normothermic Machine Perfusion
- Future Directions in Ex Vivo Liver Perfusion
- Ex Vivo Lung Perfusion
- ANIMAL MODELS
- Porcine Models
- Rodent Models
- Human Observational Studies
- Discarded Lungs
- Biomarkers
- Published Trials
- Ongoing Trials
- FUTURE DIRECTIONS
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- The Future of Organ Donation and Transplantation: 2018 and Beyond
- Robert S.D. Higgins*
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Subject Index
- Back Cover
