The GnRH Neuron and its Control
Description
The GnRH Neuron and its Control examines the developmental biology of GnRH neurons including their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation, in addition to the hypothalamic mechanisms that control GnRH neurons in adulthood to generate pulsatile and surge modes of GnRH secretion throughout the major life stages including aging. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying function of the adult GnRH neuron is discussed in detail, as is the neuroendocrinology and cell biology governing the generation of both modes of GnRH release.
The book also reviews the neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition, and metabolism, and covers the current and potential therapeutic approaches to regulating GnRH secretion and action. Filled with newly identified research and classical fundamental knowledge to GnRH biology, it will provide students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology.
This is the fifth volume in the Masterclass in Neuroendocrinology Series, a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
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Persons
Editors:
Allan E. Herbison, University of Otago, New Zealand.
Tony M. Plant, University of Pittsburgh, USA.
Content
List of Contributors vii
Series Preface xi
Preface xiii
About the Companion Website xv
Part I Historical Introduction to the GnRH Neuron
1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built 3 Tony M. Plant and Allan E. Herbison
Part II GnRH Neuron Development
2 Prenatal Development of GnRH Neurons 15 Yufei Shan and Susan Wray
3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin-GnRH NeuronalNetwork 43 Hiroko Tsukamura, Kei-ichiro Maeda and Yoshihisa Uenoyama
4 Postnatal Development of GnRH Neuronal Function 61 Ei Terasawa
Part III GnRH Neuron Biology
5 Regulation of GnRH Gene Expression 95 Hanne M. Hoffmann and Pamela L. Mellon
6 Morphology of the Adult GnRH Neuron 121 Rebecca E. Campbell
7 The Anatomy of the GnRH Neuron Network in the Human 149 Katalin Skrapits and Erik Hrabovszky
8 Electrophysiology of Rodent GnRH Neurons 177 Richard Piet and Allan E. Herbison
9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish 203 Yoshitaka Oka
Part IV Regulation of GnRH Neuron Function
10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH NeuronalFunction 227 Vincent Prevot and Ariane Sharif
11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons 259 Michael Candlish, Philipp Wartenberg and Ulrich Boehm
12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats 289 Robert L. Goodman, Satoshi Okhura, Hiroaki Okamura, Lique M. Coolen and Michael N. Lehman
13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen 325 Iain Clarke
14 Influence of Stress on the GnRH Neuronal Network 357 Pasha Grachev and Kevin T. O'Byrne
15 Metabolic Regulation of GnRH Neurons 383 Maggie C. Evans and Greg M. Anderson
16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel CentralMechanisms Governing Mammalian Reproduction 411 Sébastien Milesi, Paul Klosen and Valerie Simonneaux
Part V GnRH in the Clinic
17 Human Genetics of GnRH Neuron Function 445 A. Kemal Topaloglu and L. Damla Kotan
18 Modulators of GnRH Secretion and Therapeutic Applications 469 Claire L. Newton, Ross C. Anderson and Robert P. Millar
Index 499
