Trends in High Pressure Bioscience and Biotechnology

Introduction.High pressure bioscience and biotechnology: a century and a decade perspective (K. Heremans). Protein and macromolecules.Structural features and dynamics of protein unfolding (R. Lange, et al.). A discussion of the physical basis for the pressure unfolding of proteins (C.A. Royer). Thermal and pressure stability of Phe46 mutants of ribonuclease A (E. Chatani, R. Hayashi, R. Lange, C. Balny). Pressure and temperature-induced denaturation of carboxypeptidase Y andprocarboxypeptidase Y (M. Kato, R. Hayashi, R. Lange, C. Balny). Compression and expansion of biomatter: predicting the unpredictable? (K. Heremans, et al.). Fluctuation of apomyoglobin monitored from H/D exchange and proteolysis under high pressure (N. Tanaka, et al.). Effect of pressure treatment on hydrophobicity and SH groups interactions of myofibrillar proteins (N. Chapleau, S. Delépine, M. de Lamballerie-Anton). Effects of mutation and ligand binding on the compressibility of a protein (K. Gekko, T. Kamiyama, E. Ohmae, K. Katayanagi). Effect of glycosylation on the mechanism of renaturation of carboxypeptidase Y (M. Dumoulin, et al.). Pressure studies on protein folding, misfolding, protein-DNA interactions and amyloidogenesis (D. Ishimaru, et al.). High pressure gel mobility shift analysis and molecular dynamics: investigating specific protein-nucleic acid recognition (T.W. Lynch, et al.). Aggregation and gel formation of proteins after combined pressure-temperature treatment (L. Smeller, F. Meersman, J. Fidy, K. Heremans). Behavior of actin under high pressure (Y. Ikeuchi, et al.). Effect of pressure and pressure-denaturation on fast molecular motions of solvated myoglobin (W. Doster, et al.). Structural changes in chicken myosin subfragment-1 induced by high hydrostatic pressure (T. Iwasaki, K. Yamamoto). In situ measurements of the solubility of protein crystals under high pressure (Y. Suzuki, et al.). Effects of pressure on growth kinetics of protein crystals(Y. Suzuki, et al.). Lipid bilayer membrane and lipid protein interaction.Pressure effects on the structure and phase behavior of phospholipid-gramicidin bilayer membranes (J. Eisenbläetter, M. Zein, R. Winter). Effect of pressure on the bilayer phase transition of diacylphosphatidylethanolamine (S. Kaneshina, S. Endo, H. Matsuki, H. Ichimori). Effect of deuterium oxide on the phase transitions of phospholipid bilayer membranes under high pressure (H. Ichimori, F. Sakano, H. Matsuki, S. Kaneshina). Effect of pressure on the bilayer phase transitions of N-methylated dipalmitoylphosphatidylethanolamines (H. Matsuki, M. Kusube, H. Ichimori, S. Kaneshina). Enzymes in membrane-like surfactant-based media: perspectives for pressure regulation (N.L. Klyachko, et al.). High-pressure-induced hemolysis is characterized by release of membrane vesicles from human erythrocytes (T. Yamaguchi, S. Terada). Protein aggregation in the system "Aerosol-OT-water-octane" and its regulation by pressure application (N.L. Klyachko, S.V. Shipovskov, F. Meersman, K. Heremans). Enzyme and enzyme reaction.Hydration and conformation changes during enzyme catalysis: from molecular enzymology to enzyme engineering and biotechnology (P. Masson). Enzyme-substrate specific interactions: in situ assessments under high pressure (A. Fernández García, P. Butz, R. Lindauer, B. Tauscher). High-pressure enhancement of cellulase activities (T. Yamanobe, K. Obuchi). Kinetics of lipoxygenase inactivation in soybean and green beans(Indrawati, A.M. Van Loey, L.R. Ludikhuyze, M.E. Hendrickx). Effects of high pressure treatment on rabbit muscle proteasome(S. Yamamoto, et al.). Cell physiology and molecular biology.Molecular mechanisms of pressure-regulation at transcription level in piezophilic bacteria (C. Kato, et al.). The biological significance of tryptophan availability on high-pressure growth in yeast (F. Abe, K. Horikoshi).