Macromolecules Regulating Growth and Development

Contributors and Presiding ChairmanPrefaceI. Regulatory Factors in the Selective Growth of Mammalian Cells Role of the Cell Surface in Growth and Transformation I. Introduction II. Loss of Density-Dependent Growth Control in Transformed Cells and Cell Surface Alterations III. Mitosis and Surface Changes during the Cell Cycle of Untransformed Cells in Culture References Epidermal Growth Factor: Chemical and Biological Characterization I. Introduction II. Chemistry of the Epidermal Growth Factor III. Biology of the Epidermal Growth Factor References Tumor Angiogenesis: Role in Regulation of Tumor Growth I. Introduction II. Inhibition of Tumor Growth in the Absence of Angiogenesis III. Stimulation of Capillary Proliferation by Tumor Occurs at a Distance IV. Evidence for Humoral Transmission of Tumor Angiogenesis: Tumor Angiogenesis Factor V. Bioassays for Tumor Angiogenesis Factor VI. Summary References Hormonal Control of Oviduct Growth and Differentiation I. Introduction II. Estrogen-Mediated Differentiation III. The Cell Cycle IV. Properties of Oviduct Chromatin V. Messenger RNA Translation ReferencesII. Formation and Organization of Plant Cell Walls and the Plasma Membrane Origin and Growth of Cell Surface Components I. Introduction II. Origin and Growth of Cell Surface Components in Rapidly Elongating Pollen Tubes III. Origin and Growth of the Plasma Membrane IV. Summary References The Role of Hydroxyproline-Rich Proteins in the Extracellular Matrix of Plants I. Introduction II. Localization of Hydroxyproline III. Chemistry of Hydroxyproline-Rich Glycoproteins IV. Ariadne's Thread References Synthesis and Secretion of Proteins in Plant Cells: the Hydroxyproline-Rich Glycoprotein of the Cell Wall I. Introduction II. Biosynthesis of Peptidylhydroxyproline III. Glycosylation of Peptidylhydroxyproline IV. Secretion of the Glycoprotein V. Characterization of Cell Wall Glycoprotein and Its Cytoplasmic Precursor VI. Regulation of Cell Wall Protein Synthesis References Lipids and Membrane Structure I. Specificity of Hydrophobic Associations in Lipoproteins II. Amphipathic Lipids of Membranes III. Lipid Bilayer Structure in Membranes IV. Lipid Content of Biological Membranes V. Specificity of Hydrocarbon Chains Associated with Amphipathic Lipids VI. Oxidation Resistance of Membrane Lipids VII. Lipids and Development VIII. Membrane Models ReferencesIII. Organization and Expression of Genetic Information Organization of DNA and Proteins in Mammalian Chromosomes I. Introduction II. Observations and Interpretation References The Multiple Relations of tRNA to Metabolic Control Text References Total Synthesis of Transfer RNA Genes Text Biosynthesis of Bacterial Ribosomes Text References The Structural Basis of Selective Gene Expression in Eukaryotes I. Introduction II. The Extent of Transcription in Eukaryotic Cells III. Chemical and Physical Properties of Chromatin IV. Thermal Denaturation of Chromatin V. Characterization of DNA in Fractionated Chromatin VI. Conclusions VII. Summary References Gene Manipulation: Progress and Prospects I. Introduction II. Progress with Microbial Systems III. Possible Applications to Humans IV. A Current Example V. Nature of the Problem Posed by Gene Manipulation VI. Steps Toward a Solution ReferencesSubject Index