Extracellular Matrix
Published on 2. December 2012
436 pages
978-0-323-15041-5 (ISBN)
Description
Extracellular Matrix contains the proceedings of the symposium ""The Extracellular Matrix,"" sponsored by the Michigan Molecular Institute and held in Midland, Michigan, on June 28-July 2, 1982. The papers explore the role played by the extracellular matrix (ECM) in the physiology of a cell, particularly in the regulation of cellular phenotypes, differentiation, and proliferation. The progress made in isolating and defining the chemistry and functional interactions of the ECM components is discussed, along with the biology of the ECM. This book is comprised of 52 chapters and begins with an introduction to the ECM, with emphasis on the question of whether the malignant process can be defined in a cell culture model, and in particular, whether the pericellular matrix is characteristically altered in cancer. The discussion then turns to the structure of the heparan sulfate proteoglycans and the molecular mechanisms responsible for the association of these molecules with the surfaces of cultured cells. Subsequent chapters focus on the chemistry of ECM components such as collagen, glycosaminoglycans, and adhesive glycoproteins, along with their functional interactions, biosynthesis, turnover, and degradation. The final section is devoted to the diseased states of ECM. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.
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Susan Hawlees | John L. Wang
Extracellular Matrix
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01/1982
Academic Press
€65.72
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Content
ParticipantsPrefaceIntroduction Perspectives in Extracellular Matrix Research: The Role of Cell Culture ModelsI Chemistry of ECM components: Collagens, Glycosaminoglycans,and Adhesive Glycoproteins Heparan Sulfate: On the Structure and Function of the Cell-Associated Proteoglycans Structure and Function of Fibronectin Structure and Biosynthesis of Cartilage Collagens Interactions and Assembly of Basement Membrane ComponentsII Systems for Studying the Role of ECM in Growth and Differentiation Cell-Matrix Interaction in Embryonic Avian Cornea and Lens Patterns of Proteoglycan Synthesis during Chondrogenesis Proteoglycan Synthesis by Proliferating, Non-Proliferating, and Senescent Cultures of Human Embryo Lung FibroblastsIII Cell-Substratum Adhesion and Adhesion-Deficient Cell ines The Effect of Different Proteoglycans on Serum-Mediated Cell Adhesion and Spreading Adhesions and Cellular Adhesion Selection of Substratum-Specific Adhesion Variants of Rat Hepatoma (HTC) Cells Characterization of Cell Surface Heparan Sulfates Produced by Adhesion-Deficient Cell Lines On the Mechanism of Cell Adhesion to Substratum in Metastatic and Other Tumor CellsIV Biological Effects of the ECM in Tissue Interactions and Differentiation Scanning Electron Microscopy (SEM) of the Extracellular Matrix Meshwork during Cranial Neural Crest Cell Migration in Chick Embryos The Role of the Extracellular Matrix in the Control of Neural Crest Cell Migration Tunicamycin-Induced Defects in the Mouse Embryo: An In Vitro Study Proteins of the Embryonic Extracellular Matrix: Regional and Temporal Correlation with Tissue Interaction in the Heart Parameters Influencing Formation and Migration of Cardiac Mesenchymal Cells in Three-Dimensional Collagen Gels Collagen Biosynthesis as a Key Regulatory Step in the Hormone-Induced Differentiation of the Mouse Mammary Gland Influence of Extracellular Matrix, Laminin, and Fibronectin on the Growth of Cultured Mammalian Lens Epithelial Cells The Role of ECM in the Development of Invertebrates: A Phylogeneticist's View Glycosaminoglycans in and around Transplantable Hepatomas of Varying Growth Rates and Metastatic Characteristics The Extracellular Matrix in the Control of Prostate Cell GrowthV Functional Interactions of ECM Components Functions for Fibronectin, Hyaluronate, and Heparan Proteoglycans in Substratum Adhesion of Fibroblasts Transformation-Dependent Alterations in the Composition and Interactions of Glycoproteins in the Extracellular Matrix of Human Fibroblasts: Characteristics of GP140 and GP250 Transformation Specific Protein of the Extracellular Matrix Carbohydrates Protect the Collagen-Binding Domain of Fibronectin against Proteolytic DegradationVI Growth of Cells on Surfaces Derivatized with ECM Components Extracellular Matrix and Morphogenesis: Collagen Overlay Induces Lumen Formation by Epithelial Cell Lines Extracellular Glycoprotein Mediates the Binding of Hyaluronate to In Situ Migrating Chick Cardiac MesenchymeVII Structural and Functional Studies of the Components of the ECM Studies on the Major Carbohydrate from Human Placental Cellular Fibronectin Specific Attachment of Collagen to Cardiac Myocytes: In Vivo and In Vitro Laminin and Heparan Sulfate in Matrix Attachment of Teratocarcinoma-Derived Endodermal Cells An Integral Membrane Proteoglycan is Capable of Binding Components of the Cytoskeleton and the Extracellular Matrix Subcellular Sites of Elongation of Hyaluronate Suppression of Sulfated-Proteoglycan Biosynthesis in Chondrocyte Cultures by Calcium Ionophores Immunochemical Analysis of cAMP during Murine Limb Chondrogenesis In Vitro A Biochemical Profile of the ECM during the Sequential Stages of Otic Capsule Formation In Vivo and In Vitro Elaboration of Extracellular Matrix and Reverse Transformation of Chinese Hamster Ovary CellsVIII Modulati
