Innate Immunity: Resistance and Disease-Promoting Principles
Resistance and Disease-Promoting Principles
1st Edition
Published on 5. June 2013
130 pages
978-3-318-02348-0 (ISBN)
Available for download
Description
Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the 'state of the art' in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.
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G. Hartmann | H. Wagner
Innate Immunity: Resistance and Disease-Promoting Principles
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Content
- Cover
- Front Matter
- Contents
- Preface
- Innate Immunity
- The Else Kröner-Fresenius-Stiftung
- Introduction
- Innate Immunity's Resurrection: How It Perceives Infection
- Innate Immunity's Vibrancy: How Does It Promote Diseases?
- Innate Immunity and the Gut: How It Impacts Gut Microbiota Homeostasis
- Concluding Remarks
- Chapter 1: Innate Immunity and Inflammation
- Innate Immunity, Inflammation and Colorectal Cancer
- Abstract
- Results
- Discussion
- References
- Immunobiology of C-Type Lectin Receptors
- Abstract
- Danger Recognition by C-Type Lectin Receptors
- C-Type Lectin Receptor Effector Pathways
- Conclusions
- References
- Mechanisms of IL-1beta Maturation in Neutrophils
- Abstract
- Neutrophils at the Interface of an Inflammatory Response
- Synthesis and Maturation of IL-1beta
- The Inflammasomes
- Caspase 1-Independent Release of IL-1
- Mechanism of Secretion of IL-1beta by Neutrophils
- Conclusion
- Acknowledgements
- References
- Chapter 2: Innate Immunity and Transplantation
- The Innate Immune System: Its Rediscovery before Toll Was Described
- Abstract
- References
- Innate-Adaptive Immune Responses in Organ Ischemia/Reperfusion Injury
- Abstract
- Introduction
- Toll-Like Receptor System in Ischemia/Reperfusion-Triggered Innate Immune Activation
- Non-Toll-Like Receptors in Ischemia/Reperfusion-Mediated Innate Immune Activation
- IL-10 in Ischemia/Reperfusion Innate Immune Signaling
- T Cells in Ischemia/Reperfusion Innate Immune Activation
- Conclusion
- References
- Tolerogenic Dendritic Cells in Transplantation: From Preclinical to Clinical Application
- Abstract
- Tolerogenic Dendritic Cells in Animal Models
- Tolerogenic Dendritic Cells in Humans
- From Bench to Bedside
- Conclusion
- Acknowledgements
- References
- Chapter 3: Innate Immunity and Intestinal Microbiota
- Microbiota's Influence on Immunity
- Abstract
- Gut Clostridia Affect the Immune System
- Regulatory T Cells in the Gut
- Clostridia-Mediated Treg Cell Induction
- Conclusion
- References
- Inflammasomes and Mucosal Immune Response
- Abstract
- Inflammasome Activation and Function
- Inflammasomes and the Intestinal Mucosal Immune Response
- The Inflammasome and Carcinogenesis
- Inflammasomes as Regulators of Metabolic Disorders
- References
- Microbial Endocrinology: An Evolution-Based Shared Mechanism Determining Microbiota's Influence on Health and Disease
- Abstract
- Discussion
- Conclusions
- Acknowledgements
- References
- Chapter 4: Innate Immunity and Disease Promotion
- Standing Guard: Innate Lymphoid Cells Promote Immunity and Tissue Homeostasis at Barrier Surfaces
- Abstract
- Identification of Group 2 Innate Lymphoid Cells
- Identification of Innate Lymphoid Cells in the Lungs of Mice and Humans
- Group 2 Innate Lymphoid Cells Regulate Airway Inflammation
- Innate Lymphoid Cells Promote Airway Epithelial Repair
- A Role for Lung Innate Lymphoid Cells in Anti-Helminth Immunity?
- Implications for Targeting Group 2 Innate Lymphoid Cells in Human Disease
- Identification of Group 3 Innate Lymphoid Cells
- ROR gammat+ Innate Lymphoid Cells Promote Protective Immunity against Enteric Pathogens
- Group 3 Innate Lymphoid Cells Promote Extraintestinal Tissue Regeneration
- Innate Lymphoid Cells Regulate Containment of Commensal Bacteria to Maintain Homeostasis
- Targeting Group 3 Innate Lymphoid Cells in Human Disease
- Conclusions
- Acknowledgements
- References
- Note Added in Proof
- miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor Signaling
- Abstract
- Results
- Conclusions
- References
- Type 2 Diabetes and Islet Inflammation
- Abstract
- Evidence for an Islet Inflammatory Process inbeta-Cell Failure during Type 2 Diabetes
- Regulation of IL-1beta Expression by Nutrients in Human Islets
- The Inflammasome as a Sensor of Metabolic Stress
- IL-1 Is a Master Regulator of Tissue and Islet Inflammation in Type 2 Diabetes
- Role of Insulitis in Obesity and Type 2 Diabetes: From Islet Adaptation to Failure
- Clinical Validation and Therapeutic Consequences
- References
- The Innate Immune System in Alzheimer's Disease
- Abstract
- Misfolded Proteins in Alzheimer's Disease and Other Neurodegenerative Diseases
- Microglia and IL-1beta in Alzheimer's Disease
- Misfolded Proteins as Activators of the Inflammasome
- Conclusions
- References
- Role of Inflammasomes in Obesity
- Abstract
- References
- Gut-Brain Communication in the Regulation of System Metabolism
- Abstract
- Ghrelin
- Insulin
- Amylin
- Cholecystokinin
- Cleavage Products of Proglucagon
- References
- Chapter 5: Drosophila and Immunity
- Metabolism and Innate Immunity: FOXO Regulation of Antimicrobial Peptides in Drosophila
- Abstract
- The Innate Immune System
- Antimicrobial Peptides
- The Drosophila Immune Pathways
- Local and Systemic Immune Defense
- Insulin Signaling and the FOXO Transcription Factor
- FOXO-Dependent Regulation of Antimicrobial Peptides
- Drosophila Innate Immunity and the Gut Microflora Community
- Receptors for Antimicrobial Peptides in the Brain of Drosophila?
- Acknowledgements
- References
- Chapter 6: Innate Signaling and Adaptive Immunity
- Dendritic Cells Orchestrate Innate Immunity against Bacterial Kidney Infection
- Abstract
- Results
- Conclusions
- Acknowledgments
- References
- Chapter 7: Speakers at the Symposium
- Speakers at the Symposium
- David Artis, PhD
- Bruce Beutler, MD
- Maria Cristina Cuturi, MD
- Vishva Dixit, MD
- Vishwa Deep Dixit, DVM, PhD
- Marc Y. Donath, MD
- Richard Flavell, PhD
- Anne Halle, MD
- Michael Hoch, PhD
- Kenya Honda, MD, PhD
- Veit Hornung, MD
- Michael Karin, PhD
- Daniel Kastner, MD, PhD
- Jerzy Kupiec-Weglinski, MD, PhD
- Christian Kurts, MD
- Walter G. Land, MD
- Eike Latz, MD
- Mark Lyte, PhD
- Luke O'Neill, PhD
- Eyal Raz, MD
- Jürgen Ruland, MD
- Matthias Tschöp, MD
- Harald von Boehmer, MD, PhD
- Editors
- Hermann Wagner, MD, PhD
- Gunther Hartmann, MD, PhD
- Author Index
- Subject Index
- Cover
