Cytogenetics of Cells in Culture
Published on 18. July 2014
326 pages
978-1-4832-8199-5 (ISBN)
Description
Cytogenetics of Cells in Culture is a compendium of papers that deals with techniques to detect patterns of DNA replication, cellular control mechanisms, and chromosome analyses with automated instrumentation. Some papers discuss the effects of cell hybridization and of noxious substances such as radiation, chemical agents, and viruses on chromosomal patterns. Other papers focus on the influence of altered chromosomal complement on the survival of cells to long-term tissue culture or to ionizing radiation treatment. A couple of papers points out that naturally occurring chromosomal abnormalities in mammalian populations are relatively rare and are not necessarily associated with physical defects or disease. One paper notes that chromosomes in cells with different functions have different patterns of replication in which the changes are small and hidden. The chromosomes will usually be neutralized showing little of the characteristic pattern of replication or condensation during the early cleavage stages, that will later change into differentiated characteristic ways for each tissue type. Another paper describes chromosome breakage associated with viruses and DNA inhibitors. The compendium can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or physiology.
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Content
DedicationList of ContributorsPrefaceCytogenetic Alterations in Mixed Cultures of Mammalian SomaticCells in VitroHybridization of Somatic Cells in VitroSelection Pressure in Mammalian Cell PopulationsPhase Cinematography Studies on the EfFects of Radiation and of Some Chemicals on Cells and ChromosomesCellular Interpretation of Aspects of the Acute Mammalian Radiation SyndromeRetention of Euploidy and Mutagenicity of Heterochromatin in CultureThe Nature, Origin, and Genetic Implications of Structural Abnormalities of the Sex Chromosomes in ManChromosome Studies in the General PopulationAlterations Chromosomiques dans des Cellules Cultivees en Presence d'Extraits Tissulaires HeterospecifiquesChromosomal Studies on Human Leucocytes Following Treatment with Radioactive Iodine in Vivo and in VitroThe Limited in Vitro Lifetime of Human Diploid Cell StrainsRegulation of DNA Replication and Variegation-Type Position EffectsIdentification and Characterization of Human Chromosomes by DNA Replication SequenceMutagenic Response of Human Somatic Cell LinesDNA Synthesis and Chromosomal Morphology of Chinese Hamster Cells Cultured in Media Containing N-Deacetyl-N-Methyl-colchicine (Colcemid)Heterochromatin in the Human MaleChromosome Breakage Associated with Viruses and DNA InhibitorsQuantitation and Automation of Chromosomal Data with Special Reference to the Chromosomes of the Hamshire Pig (Sus Scrofa)Author Index
