The Septins
Published on 20. November 2008
380 pages
978-0-470-77969-9 (ISBN)
Description
"The authors represent most of the key figures and the work andthe book as a whole is an essential reference for the newcomer orspecialist in this area and for any student of eukaryotic cellstructure and function. This is an important and wonderfulreference." -Microbiology Today, May 2009
Septins are an evolutionarily conserved group of GTP-binding andfilament-forming proteins that were originally discovered in yeast.Once the preserve of a small band of yeast biologists, the fieldhas grown rapidly in the past few years and now encompasses thewhole of animal and fungal biology. Furthermore, septins arenowadays recognized to be involved in a variety of diseaseprocesses from neoplasia to neurodegenerative conditions.
This book comprehensively examines the septingene family and their proteins, providing those new to thisresearch area with a detailed and wide ranging introduction toseptin biology. It starts with a unique historical perspective onthe development of the field, from its beginnings in the screen forcell division mutants by the Nobel Laureate Lee Hartwell. Theevolution of the septin gene family then forms a basis forconsideration of the biochemistry and functions of septins in yeastand other model organisms including C. elegans andDrosophila.
A major part of the book considers the diversity of septins inmammals, their functions and properties as well as theirinvolvement in normal and abnormal cellular states, followed by aspeculative overview from the editors of the key questions inseptin research and of where the field may be headed.
In addition, several appendices summarise important informationfor those in, or just entering, the field, e.g. nomenclature andseptin and septin-like sequences.
This book is an essential source of reference materialfor researchers in septin biology, cell biology, genetics andmedicine, in particular pathology, including areas of neurobiology,oncology, infectious disease and developmental biology.
Reviews / Votes
"The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference." (Microbiology Today, May 2009)More details
Other editions
Additional editions
Peter A. Hall | S. E. Hilary Russell | John R. Pringle
The Septins
Software
11/2008
Wiley
€110.15
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Peter A. Hall | S. E. Hilary Russell | John R. Pringle
The Septins
Book
11/2008
Wiley
€180.50
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Persons
SE Hilary Russell, Senior Lecturer in Oncology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland.
Peter A. Hall, Musgrave Professor of Pathology & Consultant Pathologist, Queens University Department of Pathology & The Royal Hospitals Trust,?Belfast, Northern Ireland.
John R. Pringle, Professor of Genetics, Stanford University Medical Center, CA, USA.
Content
Contents
Authors and Affiliations vii
An introduction to the septins 1
Peter A. Hall, S. E. Hilary Russell and John R.Pringle
Section I Setting the scene 5
Chapter 1 Origins and development of the septin field7
John R. Pringle
Chapter 2 Evolution and conserved domains of the septins35
Michelle Momany, Fangfang Pan and Russell L. Malmberg
Section II Septins in model systems 47
Chapter 3 Biochemical properties and supramoleculararchitecture of septin hetero-oligomers and septin filaments49
Michael A. McMurray and Jeremy Thorner
Chapter 4 Yeast septins: a cortical organizer 101
Yves Barral
Chapter 5 Septins in four model fungal systems: diversity inform and function 125
Amy Gladfelter and Peter Sudbery
Chapter 6 Septins in the metazoan model systemsDrosophila melanogaster andCaenorhabditis elegans 147
Christine M. Field, Amy Shaub Maddox, John R. Pringle andKaren Oegema
Section III Septins in mammals 169
Chapter 7 The genomics and regulation of the humanseptin
genes 171
S.E. Hilary Russell
Chapter 8 The functions of septins in mammals 187
Carol D. Froese and William S. Trimble
Chapter 9 Septin-interacting proteins in mammals 211
Brandon E. Kremer and Ian G. Macara
Chapter 10 Septin functions in the mammalian cytoskeleton229
Elias T. Spiliotis and W. James Nelson
Chapter 11 Septins and the synapse 247
Jing Xue, Victor Anggono and Phillip J. Robinson
Chapter 12 Septins and platelets 269
Jerry Ware, Constantino Mart´inez and BarbaraZieger
Chapter 13 Septins and apoptosis 281
Marie-Jeanne Carp and Sarit Larisch
Chapter 14 Septins and human disease 295
Peter A. Hall and Fern P. Finger
Chapter 15 Insight into septin functions from mouse models319
Makoto Kinoshita
Section IV Envoi 337
Chapter 16 Septins: 2008 and beyond 339
Peter A. Hall, S.E. Hilary Russell and John R.Pringle
Appendix A Septin and septin-like sequences 343
Michelle Momany, Fangfang Pan and Russell L. Malmberg
Appendix B Mammalian septin nomenclature 351
Peter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macaraand John R. Pringle
Appendix C Septin meetings and workshops 355
Peter A. Hall and John R. Pringle
Index 361
