Cellular Transplantation
From Laboratory to Clinic
Published on 10. October 2011
696 pages
978-0-08-046904-1 (ISBN)
Description
There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy.
Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier.
The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices.
- Provides detailed description of clinical trials in cell transplantation
- Review of current therapeutic approaches
- Coverage of the broad range of diseases addressed by cell therapeutics
- Discussion of stem cell biology and its role in transplantation
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Book
02/2007
Academic Press
€235.50
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Content
A. BASIC BIOLOGY OF CELL THERAPY1. Immunology of Cell and Tissue Transplantation2. Current Immunosuppressive Drugs and Clinical Use3. Stem and Precursor Cells for Transplant Therapy4. Creating Animals for Cell Xenotransplantation
B. CELL THERAPY FOR PERIPHERAL DISEASES AND RECONSTRUCTIVE APPLICATIONS5. Islet Transplants for Diabetes: The Edmonton Protocol6. Colton-To Come7. Encapsulated Human Islet Allografts: Providing Safety with Efficacy8. Strategies for Cell Replacement for Kidney Failure9. Strategies for Extracorporeal Devices for Kidney Failure10. Transplants for Hemophilia11. Cell Therapy for Peripheral Diseases and Reconstructive Applications: Transplants for Lysosomal Storage Disease12. Cellular Transplants for Liver Diseases13. Stem Cell Transplantation for Autoimmune Diseases14. Cardiac Cell Transplantation15. Engineered Cylindrical Cartilage Transplantation as Tracheal Replacements16. Muscle Cell Transplants
C. CELL THERAPY FOR CNS DISEASES.17. Immunological Consideration in CNS Transplants18. Neurotrophic Cell Transplants for Degenerative Diseases of the Eye19. Transplants for Glioblastoma20. NT2N Cell Transplantation and GDNF Treatment in Stroke: Linking Neurotrophic Factor Therapy and Neuroprotection21. NGF Producing Cell Transplants for Alzheimer's Disease22. Transplants of CNTF-Producing Cells for the Treatment of Huntington's Disease23. Choroid Plexus Epithelial Cell Transplants for Repair of the Brain24. Neural Transplantation in Huntington's Disease25. Neural Transplantation in Parkinson's Disease26. Transplants for Chronic Pain27. Cell Grafting for Spinal Cord Injury Repair: Cell Replacement and Bridging Strategies28. Human Embryonic Stem Cells, Dopaminergic Neurons, and Pathways for Developing a Parkinson's Disease Therapy
D. FUTURE AVENUES OF CELL THERAPY.29. Concepts in Cell Therapy: From Cord Blood to Sertoli Cells30. Immunologically Privileged Environments31. Converging Cell Therapy with Biomaterials32. Nanotechnology's Impact on Cell Transplantation33. Design and Implementation of a Cell Processing Facility34. Developing Cell Therapy Products
