Vitiligo
Description
This complete guide to vitiligo provides a full appraisal of strategy for the treatment of this autoimmune disease that affects 1-2% of the world's population. It addresses all aspects of vitiligo, covering the science, medical and surgical therapies, and the psychological evaluations and approaches based on the proper understanding of the causes and classification of a particular case.
Management of vitiligo is challenging and requires a multipronged approach. Vitiligo: Medical and Surgical Management is a comprehensive, timely, state-of-the-art resource that will help those involved with affected patients better understand and treat this disease, which takes its toll on the mental wellness of those afflicted by it. It takes an evidenced-based approach to the disease's treatment; provides an overview of the surgical management; covers tissue and cellular grafting; and more.
* Thoroughly guides those involved in the clinical aspects of vitiligo
* Aids diagnosis and classification of severity
* Balances evidence and experience
* Compiled by world-leading expert editors
Comprehensive in nature, Vitiligo: Medical and Surgical Management contains a strong practical element, and is a welcome go-to source for practicing dermatologists and those training to become a dermatologist.
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About the Editors
Somesh Gupta, MD, DNB, MNAMS, Professor, Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India
Mats J. Olsson, MD, PhD, CEO, ParkCell AB and President, International Vitiligo Center, Uppsala, Sweden
Davinder Parsad, MD, Professor, Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Henry W. Lim, MD, Chair Emeritus, Department of Dermatology and Senior Vice President for Academic Affairs, Henry Ford Health System. Past President, American Academy of Dermatology, Detroit, USA
Nanja van Geel, MD, PhD, Professor, Department of Dermatology, Ghent University Hospital, Ghent, Belgium
Amit G. Pandya, MD, Professor, Department of Dermatology, University of Texas, Southwestern Medical Center, Dallas, USA
Content
List of Contributors xiii
Foreword xix
Preface xxi
About the Companion Website xxiii
Section 1 Basic Science 1
1 Introduction 3 Somesh Gupta and Nanja van Geel
2 Melanocyte and Melanogenesis: Applied Anatomy and Physiology 9 Reinhart Speeckaert and Nanja van Geel
3 Epidemiology of Vitiligo 15 Nader Aboul-Fettouh and Amit G. Pandya
4 Pathogenesis of Vitiligo 19 John E. Harris
5 Understanding the Mechanisms of Repigmentation in Vitiligo 27 Ravinder Kumar, Davinder Parsad, and Amrinder J. Kanwar
Section 2 Clinical Science 33
6 Classification and Clinical Features of Vitiligo 35 Sang Ho Oh and Seung-Kyung Hann
7 Outcome Measures for Vitiligo 49 Brian Clinton, Viktoria Eleftheriadou, Nanja van Geel, Laila Benzekri, Amit G. Pandya, and Khaled Ezzedine
8 Evaluation and Treatment of the Psychosocial Burden of Vitiligo 61 Vishal Gupta and M. Ramam
9 Patient Support, Education, and Compliance 69 Richard H. Huggins, Jackie Gardner, and Amit G. Pandya
10 Goals of Vitiligo Treatment, and Evidence-Based Practice Guidelines for Medical and Surgical Management 77 Kevin Prier and Amit G. Pandya
11 The Concept of Stability of Vitiligo and Stabilization Therapies 81 Anuradha Bishnoi and Davinder Parsad
Section 3 Phototherapy 91
12 Narrow-Band Ultraviolet B Phototherapy in Vitiligo 93 Narumol Silpa-archa and Henry W. Lim
13 UVA-Based Phototherapy: PUVA, PUVA-Sol, and UVA1 Phototherapy 105 Ljubomir B. Novakovic
14 Targeted Phototherapy in Vitiligo 113 Mohammed Al-Jamal, James L. Griffith, Iltefat H. Hamzavi, and Henry W. Lim
Section 4 Medical Management 123
15 Immunomodulators and Immunosuppressives in Vitiligo Treatment 125 Anuradha Bishnoi and Davinder Parsad
16 Topical Glucocorticoids, Topical Calcineurin Inhibitors, and Topical Vitamin D3 Analogs 133 Sai Yee Chuah and Boon Kee Goh
17 Other Therapies in Vitiligo 141 Narumol Silpa-archa, James L. Griffith, Iltefat H. Hamzavi, and Pearl E. Grimes
18 Biologic Therapies for Vitiligo 151 Pablo Michel and Amit G. Pandya
19 Evidence Toward Integrated Management of Vitiligo, Combining Ayurveda and Homeopathy with Modern Dermatology 159 Saravu R. Narahari, Madhur G. Aggithaya, Kuthaje S. Bose, and Kodimoole S. Prasanna
Section 5 Surgical Therapies: History, Patient Selection, and Classification 171
20 History and Chronology of Development of Surgical Therapies for Vitiligo 173 Koushik Lahiri and Abhishek De
21 Patient Selection, Pre- and Postoperative Information in Surgical Therapies for Vitiligo 185 Nanja van Geel and Mats J. Olsson
22 Classification of Surgical Therapies in Vitiligo 193 James L. Griffith, Mohammed Al-Jamal, and Iltefat H. Hamzavi
Section 6 Surgical Therapies: Tissue Grafting 209
23 Minigrafting for Vitiligo 211 Koushik Lahiri
24 Suction Blister Epidermal Grafting 225 Savita Yadav and Somesh Gupta
25 Thin and Ultra-Thin Skin Grafts for Vitiligo 241 Imran Majid
26 Treatment of Leukoderma by Transplantation of Ultra-Thin Epidermal Sheets Using a Motorized Dermatome 249 Mats J. Olsson
27 Mesh Grafts for Vitiligo 257 Chakravarthi R. Srinivas and Reena Rai
28 Smash Grafting 261 Sumit Kar, Ajay Krishnan, and Sudhir Singh
29 Therapeutic Needling and Needling Micrografting 267 Khalifa E. Sharquie and Adil A. Noaimi
30 Complications and Limitations of Melanocyte Transplantation 273 Yvon Gauthier and Laila Benzekri
Section 7 Surgical Therapies: Cellular Grafting 279
31 Treatment of Leukoderma by Transplantation of Basal Cell Layer Suspension 281 Mats J. Olsson
32 Non-Cultured Extracted Follicle Outer Root Sheath Cell Suspension Transplantation 293 Kanika Sahni and Somesh Gupta
33 Long-Term Results of Non-Cultured Epidermal Cellular Grafting in Vitiligo 299 Nanja van Geel, Sofie De Schepper, Hilde Lapeere, Barbara Boone, Boon Kee Goh, and Reinhart Speeckaert
34 Simplified Non-Cultured Cellular Grafting 303 Boon Kee Goh
35 Novel Methods of Preparing Epidermal Cell Suspension for Transplantation in Vitiligo 309 Vishal Gupta, Sanjeev Gupta, Kanika Sahni, and Somesh Gupta
36 Management of Vitiligo: Setting Up a Tissue Culture Laboratory 317 Rafal Czajkowski, Malgorzata Maj, and Tomasz Drewa
37 Treatment of Leukoderma by Transplantation of Cultured Autologous Melanocytes 323 Mats J. Olsson
38 Transplantation of In-Vitro-Cultured Epithelial Grafts for Vitiligo and Piebaldism 337 Liliana Guerra, Sergio Bondanza, and Desanka Raskovic
39 Application of Lasers for Abrasion in Transplantation Procedures for Vitiligo 351 Gwang Seong Choi
40 Cell Delivery on Recipient Skin 357 Thomas Hunziker
41 Safety Concerns in Transplantation of In-Vitro-Cultured Cellular Grafts 363 Liliana Guerra, Elena Dellambra, Patrizia Paterna, and Somesh Gupta
Section 8 Special Issues in Medical and Surgical Therapies 369
42 Surgical Management of Vitiligo of Lips, Eyelids, and Genitals 371 Riti Bhatia and Somesh Gupta
43 Surgical Management of Acral Vitiligo 389 Munish Paul
44 Surgical Management of Leukotrichia 401 Amrendra Kumar
45 Surgical Treatments of Leukodermas Other Than Vitiligo Vulgaris 407 Mats J. Olsson
46 Ethnic Issues in Management of Vitiligo and Sun Protection 417 Haneol S. Jeong, Michelle Rodrigues, and Amit G. Pandya
47 Management Issues for Vitiligo in Children and Pregnant Women 427 Freya Van Driessche and Nanette Silverberg
48 Combination Treatments for Vitiligo 439 Anuradha Bishnoi and Davinder Parsad
49 Micropigmentation 451 Gurvinder P. Thami
50 Camouflage in Vitiligo 459 Chakravarthi R. Srinivas, Pradeep Balasubramanian, and C.K. Shashidharan Nair
51 Depigmentation Treatment for Vitiligo: Bleaching Cream, Laser, and Cryotherapy 469 Nanja van Geel and Monique R.T.M. Thissen
52 Future Directions in the Treatment of Vitiligo 475 Vishal Gupta and Somesh Gupta
53 Informed Consent 491 Mats J. Olsson
Index 495
List of Contributors
Madhur G. Aggithaya, MD
Institute of Applied Dermatology
Kerala
India
Mohammed Al-Jamal, MD
Department of Dermatology
Henry Ford Hospital
Detroit
Michigan
USA
Pradeep Balasubramanian, MD
Department of Dermatology
PSG IMSR
Coimbatore
India
Riti Bhatia, MD
Department of Dermatology and Venereology
All India Institute of Medical Sciences,
New Delhi
India
Anuradha Bishnoi, MD
Department of Dermatology
Postgraduate Institute of Medical Education & Research
Chandigarh
India
Laila Benzekri, PhD
Mohammed V University
Ibn Sina Hospital
Department of Dermatology
Rabat
Morocco
Sergio Bondanza, BSc
Laboratory of Tissue Engineering and Cutaneous Physiopathology
Istituto Dermopatico dell'Immacolata, IDI-IRCCS
Rome
Italy
Barbara Boone, PhD
Department of Dermatology
Ghent University Hospital
Belgium
Kuthaje S. Bose, LECH
Institute of Applied Dermatology
Kerala
India
Gwang Seong Choi, MD, PhD
Department of Dermatology
Inha University College of Medicine
Incheon
Republic of Korea
Sai Yee Chuah, MBChB, MRCP, MRCPS, Diploma in Dermatology
Department of Dermatology
National Skin Centre
Singapore
Rafal Czajkowski, MD, PhD, Prof. NCU
Department of Dermatology
Sexually Transmitted Diseases and Immunodermatology
Ludwik Rydygier Medical College in Bydgoszcz
Nicolaus Copernicus University in Torun
Poland
Elena Dellambra, PhD
Laboratory of Tissue Engineering and Cutaneous Physiopathology
Istituto Dermopatico dell'Immacolata IDI-IRCCS
Rome
Italy
Sofie De Schepper, MD, PhD
Department of Dermatology
Ghent University Hospital
Belgium
Tomasz Drewa, MD, PhD, FEBU
Department of Urology
Ludwik Rydygier Medical College in Bydgoszcz
Nicolaus Copernicus University in Torun
Poland
Khaled Ezzedine, MD, PhD
EA EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques)
UPE-Université Paris-Est
Service de Dermatologie
Hôpital Henri Mondor
France
Jackie Gardner
Vitiligo Support International
Lynchburg
Virginia
USA
Yvon Gauthier, MD
Pigmentary Disorders Outpatient Clinic
Department of Dermatology
Hôpital Saint André
France
James L. Griffith, MD
Department of Dermatology
Henry Ford Hospital
Detroit
Michigan
USA
Pearl E. Grimes, MD, FAAD
Vitiligo and Pigmentation Institute of Southern California
Los Angeles;
Department of Dermatology
University of California, Los Angeles
CA
USA
Liliana Guerra, MD
Laboratory of Tissue Engineering and Cutaneous Physiopathology
Istituto Dermopatico dell'Immacolata, IDI-IRCCS
Rome
Italy
Sanjeev Gupta, MD
Department of Dermatology and Venereology
Maharishi Markandeshwar Institute of Medical Sciences and Research
Ambala
India
Somesh Gupta, MD, DNB, MNAMS
Department of Dermatology and Venereology
All India Institute of Medical Sciences
New Delhi
India
Vishal Gupta, MD
Department of Dermatology and Venereology
All India Institute of Medical Sciences
New Delhi
India
Iltefat H. Hamzavi, MD, FAAD (Fellow of the American Academy of Dermatology)
Department of Dermatology
Henry Ford Hospital
Michigan
USA
Richard H. Huggins, MD, FAAD (Fellow of the American Academy of Dermatology)
Department of Dermatology
Henry Ford Health System
Detroit
Michigan
USA
Thomas Hunziker, MD
Department of Dermatology
University of Bern
Bern
Switzerland
Seung-Kyung Hann, MD, PhD
Korea Institute of Vitiligo Research & Drs Woo and Hann's Skin Center
Seoul
Korea
John E. Harris, MD, PhD
Department of Dermatology
Vitiligo Clinic and Research Center
Worcester MA
USA
Amrinder J. Kanwar, MD
Department of Dermatology
Postgraduate Institute of Medical Education & Research
Chandigarh
India
Sumit Kar, MD
Department of Dermatology, Venereology and Leprosy
MGIMS, Sewagram
Maharashtra
India
Boon Kee Goh, MD, PhD
Pigment Clinic
National Skin Center;
Skin Physicians Private Limited
Mount Elizabeth Medical Centre
Singapore
Ajay Krishnan, MD
Department of Dermatology, Venereology and Leprosy
MGIMS
Wardha
Maharashtra
India
Amrendra Kumar, MD
Dermaclinix
The Complete Skin and Hair Solution Center
New Delhi
India
Ravinder Kumar, PhD
Department of Zoology
Panjab University
Chandigarh
India
Koushik Lahiri, FRCP
Greenwood Nook
Coral Isle
Kolkata
India
Hilde Lapeere, MD, PhD
Department of Dermatology
Ghent University Hospital
Belgium
Henry W. Lim, MD
Department of Dermatology;
Academic Affairs
Henry Ford Health System
American Academy of Dermatology
Detroit, USA
Malgorzata Maj, PhD
Department of Tissue Engineering
Ludwik Rydygier Medical College in Bydgoszcz
Nicolaus Copernicus University in Torun
Poland
Imran Majid, MD (Dermatology and STD)
CUTIS Institute of Dermatology
Srinagar, Kashmi
Saravu R. Narahari, MD
Institute of Applied Dermatology
Kerala
India
Adil A. Noaimi, MD, DDV, FICMS
Department of Dermatology
College of Medicine
University of Baghdad;
Iraqi and Arab Board for Dermatology and Venereology
Baghdad Teaching Hospital
Medical City
Baghdad
Iraq
Ljubomir B. Novakovic FRCP
Department of Photodermatology
St John's Institute of Dermatology
Guy's & St. Thomas' NHS Trust
London, UK
Sang Ho Oh, MD, PhD
Department of Dermatology
Severance Hospital & Cutaneous Biology Research Institute
Yonsei University College of Medicine
Seoul
Korea
Mats J. Olsson, MD, PhD
International Vitiligo Center
Uppsala, Sweden
Amit G. Pandya, MD
Department of Dermatology
University of Texas Southwestern Medical Center
Dallas
Texas
USA
Davinder Parsad, MD
Department of Dermatology
Venereology & Leprology
Postgraduate Institute of Medical Education & Research
Chandigarh
India
Patrizia Paterna, BSc
Laboratory of Tissue Engineering and Cutaneous Physiopathology
Istituto Dermopatico dell'Immacolata, IDI-IRCCS
Rome
Italy
Kodimoole S. Prasanna, DVD
Institute of Applied Dermatology
Kerala
India
Reena Rai, MD
PSG Institute of Medical Science & Research
Coimbatore
India
M. Ramam, MD
Department of Dermatology & Venereology
All India Institute of Medical Sciences
New Delhi
India
Desanka Raskovic, MD
VI Division of Dermatology
Istituto Dermopatico dell'Immacolata, IDI-IRCCS
Rome
Italy
Kanika Sahni, MD
Department of Dermatology and Venereology
All India Institute of Medical Sciences,
New Delhi
India
Khalifa E. Sharquie, MD, PhD
Department of Dermatology
College of Medicine
University of Baghdad;
Iraqi and Arab Board for Dermatology and Venereology
Baghdad Teaching Hospital
Medical City
Baghdad
Iraq
C.K. Shashidharan Nair, PhD
Department of Physics
PSG College of Technology
Coimbatore
India
Narumol Silpa-archa, MD
Department of Dermatology
Henry Ford Health System
Detroit
Michigan
USA;
Department of Dermatology
Faculty of Medicine Siriraj Hospital
Mahidol University
Bangkok
Thailand
Nanette Silverberg, MD
Mt Sinai St Luke's-Roosevelt Hospital Center
New York
USA
Sudhir Singh, MD
Department of Dermatology, Venereology and Leprosy
DMIMSDU
Maharashtra
India
Reinhart Speeckaert, MD, PhD
Department of Dermatology
Ghent University Hospital
Belgium
Chakravarthi R. Srinivas, MD
Department of Dermatology
PSG IMSR
Coimbatore
India
Gurvinder P. Thami, MD
Department of Dermatology
Government Medical College
Chandigarh
India
Monique R.T.M. Thissen, MD, PhD
Department of Dermatology
Maastricht University Medical Centre
Netherlands
Freya Van Driessche, BS
University of Miami
Miller School of Medicine
Miami
FL
USA
Nanja van Geel, MD, PhD
Department of Dermatology
Ghent University Hospital
Ghent,...
