Reproductive and Developmental Toxicology

Section I. General1. Introduction2. Reproductive Anatomy and Physiology3. Pharmacokinetics in Pregnancy4. Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology5. Drugs and Chemical Contaminants in Human Breast Milk Section II. Toxicity Testing Models and Safety Evaluation6. Reproductive and Developmental Safety Evaluation of New Pharmaceutical Compounds7. Juvenile Toxicology Testing8. Postmarket Surveillance and Regulatory Considerations in Reproductive and Developmental Toxicology: A Food and Drug Administration Perspective9. OECD Guidelines for In Vivo Testing of Reproductive Toxicity10. Guidelines for Reproductive and Developmental Toxicity Testing and Risk Assessment of Chemicals11. Validated and Nonvalidated Mechanism-Based Methods for Testing Developmental Toxicity12. Relevance of Animal Testing and Sensitivity of End Points in Reproductive and Developmental Toxicity13. Embryonic Toxic Lesions and Stem Cell Therapy14. In Vitro and Alternative Approaches to Developmental Neurotoxicity15. In Vitro Biomarkers of Developmental Neurotoxicity16. Using Zebrafish to Assess Developmental Neurotoxicity17. Caenorhabditis elegans as a Model to Assess Reproductive and Developmental Toxicity18. A Primate as an Animal Model for Reproductive and Developmental Toxicology Testing Section III. Nanoparticles and Radiation19. Developmental Toxicity of Engineered Nanomaterials20. Toxicity of Radiation: Biological Effects of Ionizing Radiation Exposure on Reproduction Section IV. Gases and Solvents21. Reproductive and Developmental Toxicity of Solvents and Gases Section V. Drugs of Abuse and Addiction, Smoking and Alcohol22. Caffeine23. Developmental Neurotoxicity of Abused Drugs24. Effects of Alcohol on Embryo/Fetal Development25. Cigarette Smoking and Reproductive and Developmental Toxicity Section VI. Pharmaceuticals and Food Additives26. Thalidomide27. Retinoids28. Melamine and Cyanuric Acid29. Ionophores Section VII. Metals30. Boron31. Arsenic, Cadmium, and Lead32. Manganese33. Mercury34. Selenium Section VIII. Pesticides, Industrial and Other Environmental Contaminants35. Organophosphates and Carbamates36. Chlorinated Hydrocarbons and Pyrethrins/Pyrethroids37. Herbicides and Fungicides38. Brominated Flame Retardants39. Polychlorinated Biphenyls, Polybrominated Biphenyls, Polychlorinated Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans40. Reproductive Toxicity of Polycyclic Aromatic Hydrocarbons41. Toxicity and Risk Assessment of Bisphenol A42. Ethylene Glycol43. Perfluorooctane Sulfonate and Perfluorooctanoic Acid44. Phthalates45. Personal Care Products and Cosmetics Section IX. Phytotoxicants, Mycotoxins and Zootoxins46. Toxic plants47. Fumonisins48. Aflatoxins, Ochratoxins, and Citrinin49. Zootoxins Section X. Special Topics50. Systems Toxicology and Predictive Modeling of Male Developmental Toxicity51. Stem Cells in Developmental Toxicity Testing52. Epigenetics in Reproduction and Development53. Mitochondrial Dysfunction in Reproductive and Developmental Toxicity54. Cell Signaling Mechanisms in Developmental Neurotoxicity55. Neuroinflammation and Oxidative Injury in Developmental Neurotoxicity56. Effects of Stress on Reproductive and Developmental Biology57. Disruption of Cholesterol Homeostasis in Developmental Neurotoxicity Section XI. Endocrine Disruption, Mutagenicity, Carcinogenicity, Infertility and Teratogenicity58. Endocrine Disruption59. Developmental and Reproductive Disorders-Role of Endocrine Disruptors in Testicular Toxicity60. Mutagenicity and Carcinogenicity: Human Reproductive Cancer and Risk Factors61. Environmental Pollutants and Neural Tube Defects62. Teratogenicity63. Micro-Computed Tomography and Volumetric Imaging in Developmental Toxicology Section XII. Toxicologic Pathology64. Toxicologic Pathology of the Reproductive System Section XIII. Placental Toxicity65. The Placental Role in Developmental Programming66. Strategies for Investigating Hemochorial Placentation67.