Protection of Functional Groups in Peptide Synthesis

¿List of ContributorsPrefaceNomenclature and AbbreviationsContents of Previous VolumesChapter 1 Amine Protecting Groups I Introduction II Amine Protection III The Types of Amine Protecting Groups IV Selective Protection of a, ¿-Diaminocarboxylic Acids V Amide Protecting Groups VI Hydrazide Protection VII Guanidine Protecting Groups VIII Imidazole Protecting Groups IX Npyr-Protection of ß-(3-Pyrazolyl)alanine X Indole Protecting Groups XI Concluding Remarks ReferencesChapter 2 Carboxyl Protecting Groups I Introduction II Synthesis without Protection of Carboxyl Groups III Trimethylsilyl Esters IV Protecting Groups Cleaved by Mild Acid Treatment V Protecting Groups Cleaved by Hydrogenolysis VI Protecting Groups Removed by Treatment with Alkali VII Protecting Groups Cleaved by Nucleophiles under Neutral Conditions VIII Protecting Groups Cleaved by Photolysis IX Methods of Preparing Amino Acid Esters X Concluding Remarks ReferencesChapter 3 Sulfhydryl Group Protection in Peptide Synthesis I Introduction II Thioethers and Related Protective Groups III Monothioacetals, Dithioacetals, and Related Protective Groups IV Thiazolidines and Related Protective Groups V Thioesters and Related Derivatives VI Sulfenyl Derivatives (Preparation and Removal) ReferencesChapter 4 Protection of the Hydroxyl Group in Peptide Synthesis I Introduction II Synthetic Strategy for Hydroxyl-Containing Peptides: "Minimal" versus "Global" Protection III Serine in Peptide Synthesis IV Threonine in Peptide Synthesis V Hydroxyproline in Peptide Synthesis VI Other Aliphatic Hydroxy Acids: Depsipeptides VII Tyrosine in Peptide Synthesis VIII Peptide Synthesis with Other Phenolic Amino Acids IX Optical Purity of Peptides and Amino Acids ReferencesChapter 5 Differential Protection and Selective Deprotection in Peptide Synthesis I Introduction II General Methods for the Cleavage of Protecting Groups III Deprotection by Acidolysis IV Alkali-Labile Protecting Groups V Compatibility of Protecting Groups VI Differential Protection ReferencesChapter 6 Peptide Synthesis with Minimal Protection of Side-Chain Functions I Introduction II Tactics and Problems Connected with Use of Minimal Side-Chain Protection III Strategies and Examples of Syntheses with Minimal Side-Chain Protection IV Concluding Remarks ReferencesChapter 7 Dual Function Groups I Substituted Hydrazides II Esters III Miscellaneous Groups ReferencesAuthor IndexSubject Index