Major Methods of Peptide Bond Formation

¿List of ContributorsPrefaceNomenclature and AbbreviationsChapter 1 The Peptide Bond I Introduction II Nature of the Peptide Bond III Cleavage of the Peptide Bond IV Formation of the Peptide Bond V Conclusion and Outlook ReferencesChapter 2 The Formation of Peptide Bonds: A General Survey I Introduction II Coupling between Amino Acid Residues III Ab Initio Assembly of the Backbone IV Conclusions ReferencesChapter 3 Active Esters in Peptide Synthesis I The Development of Active Esters II Classes of Active Esters III Preparation of Active Esters IV Catalysis of Active Ester Reactions V Side Reactions VI Active Esters and the Strategy of Peptide Synthesis VII Active Esters in Various Techniques of Peptide Synthesis VIII Conclusions ReferencesChapter 4 The Azide Method in Peptide Synthesis I Introduction II Experimental Procedure III The Formation of Hydrazides IV The Generation of Azides V Azide Segment Condensation VI Special Applications VII Opportunities and Constraints ReferencesChapter 5 The Carbodiimide Method I Introduction II Mechanism of Carboxyl Activation III Reaction Conditions for Dicyclohexyl-Carbodiimide-Mediated Peptide Bond Formation IV Reactions of Carbodiimides with Amines ReferencesChapter 6 The Mixed Carbonic Anhydride Method of Peptide Synthesis I Introduction II The Experimental Procedure III Reaction Conditions IV Coupling Reagents: EEDQ and IIDQ V Applications VI Related Methods VII Opportunities and Constraints ReferencesChapter 7 Racemization in Peptide Synthesis I Introduction II Racemization of Amino Acids, Peptides, and Their Unactivated Derivatives III Racemization of Activated Acyl Derivatives of Amino Acids and Peptides IV Control of Racemization during Peptide Synthesis V Strategies for Minimizing Racemization During Amide-Forming Steps VI Assays for Chiral Purity ReferencesAuthor IndexSubject Index