Current Topics in Membranes and Transport

Name: Current Topics in Membranes and Transport
Brand: Academic Press
Price: 54.95 EUR
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Sergio Grinstein Ori D. Rotstein(Author)

Academic Press

Published on 23. May 1990

627 pages

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978-0-08-058506-2 (ISBN)

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Front Cover
Mechanisms of Leukocyte Activation
Copyright Page
Contents
Contributors
Preface
Yale Membrane Transport Processes Volumes, xvii
Chapter 1. Genomic Organization and Polymorphism of the T Cell Receptor
I. Introduction
II. Genomic Organization of the T Cell Receptor Genes
III. Conclusion
References
Chapter 2. Chemoattractant Receptors as Regulators of Phagocytic Cell Function
I. Physiology of Phagocytic Cell Function Mediated by Chemoattractants
II. Chemoattractant Receptor Quantification
III. Characterization of Biologically Relevant Chemoattractant Receptors
References.
Chapter 3. Involvement of GTP-Binding Proteins in T- and B-Lymphocyte Activation Signaling
I. Introduction
II. Involvement of G Proteins during Lymphocyte Activation
III. Future Perspectives
References
Chapter 4. Signal Transduction by GTP Binding Proteins during Leukocyte Activation: Phagocytic Cells
I. Introduction
II. GTP Binding Rcgdatory Proteins
III. GTP Binding Proteins as Mediators of Neutrophil Activation
IV. The GTP Binding Protein Compositton of the Neutrophil
V. Mechanisms for Regulation of Signal Transduction in the Neutrophil
VI. Concluzions
References
Chapter 5. Monovalent Ion Transport and Membrane Potential Changes during Leukocyte Activation: Lymphocytes
I. Introduction
II. Membrane Potential Change
III. pH Change
IV. NalK-ATPase of Lymphocytec
V. Anion Channels
VI. Cation Channels
VII. Conclusion
References
Chapter 6. Monovalent Ion Transport and Membrane Potential Changes during Activation in Phagocytic Leukocytes
I. Introduction
II. Ionic Basis of the Resting Membrane Potential
III. Ionic Channels, Pumps, and Carriers
IV. Role of Membrane Potential and Ionic Conductances in Phagocyte Function
V. Summary
Relerences
Chapter 7. Cytosolic Calcium Changes during T- and B-Lymphocyte Activation: Biological Consequences and Significance
I. Introduction
II. Measurement of Cellular Ca2+ Content and [Ca2+]i
III. Cytosolic Calcium Changes in Activated T Lymphocytes
IV. Cytosolic Calcium Changes in Activated B Lymphocytes
V. Summary
References
Chapter 8. Cytoplasmic Calcium in Phagocyte Activation
I. Introduction
II. Measuring and Manipulation (Ca2+]i in Intact Phagocytes
III. Basic [Ca2+]i Homeostatic Mechanisms in Phagocytes
IV. The Rise and Fall of [Ca2+ ]i Changes in [Ca2]i and Phagocyte Activation
V. The Role of Ca2+ as a Second Messenger Is Questioned in Phagocytic Cells
VI. Conclusions: Ca2+ May Not Be All, After All
References
Chapter 9. Role of Intracellular pH in Lymphocyte Activation
I. Introduction
II. Intracellular pH Changes in Nonlymphoid Cells
III. Intracellular pH Changes in T Lymphocytes
IV. Na+/H+ Antiport Activity and pHi in B Cell Differentiation
V. Conclusion
References
Chapter 10. Regulation and Functional Significance of Cytoplasmic pH in Phagocytic Leukocytes
I. Mechanisms of Cytosolic pH Regulation in Phagocytic Leukocytes
II. Role of Cytoplasmic pH in Phagocytic Cell Activation and Modulation of Function
III. pH, Changes during Phagocytic Cell Differentiation: Regulation and Significance
References
Chapter 11. Phosphoinositide Metabolism in Lymphocyte Activation
I. Introduction
II. T Cesll
III. T Cell Proliferation
IV. T Cell Responses in Cellular Immunity
V. B Cells
VI. Summary
References
Chapter 12. Phosphoinositide Metabolism during Phagocytic Cell Activation
I. Introduction
II. Phosphatidic Acid Metabolism
Ill. Role of Enzymes in Phosphoinositide Metabolism in Neutrophil Activation
IV. Conclusions
References
Chapter 13. The Role of Arachidonic Acid Metabolites in Lymphocyte Activation and Function
I. Introduction
II. Effects of Arachidonic Acid Metaholites on Lymphocyte Activation and Function
III. Lymphocyte Synthesis of Arachidonic Acid Metabolites
IV. The Effects of Lipoxygenase Inhibitors on Lymphocyte Activation and Function
V. Conclusions
References
Chapter 14. Mechanisms Regulating the Production of Arachidonate Metabolites in Mononuclear Phagocytes
I. Introduction
II. Involvement of Eicosanoid Production in Host-Defense Mechanisms
III. Biochcemical Mechanisms Involved in Eicosanoid Production
IV. Potential Transductional Mechanisins Involved in the Stimulation of Macrophage Eicosanoid Production
V. Platelet Activating Factor as an Autocrine Component of Eicosanoid Production
VI. The Relationship of Eicosanoid Production to Macrophage Development
VII. Summary
References
Chapter 15. Role of Cyclic Nucleotides in Lymphocyte Activation
I. Introduction
II. Cyclic Nucleotides as Potential Activation Signals
Ill. Modulatory Kffects of Cyclic Nucleotides in Lymphocyte Activation
IV. Interrelation of Cyclic Nucleotides with Other Signal Transduction Pathways: Possible Mechanisms of Cross-Talk
V. Conclusions
References
Chapter 16. Alterations in Cyclic Nucleotides and the Activation of Neutrophils
I. Introduction
II. Receptor-Mediated Activation of Adenylate Cyclase in Neutrophils
Ill. Cyclic AMP in Activated Neutrophils
IV. Effect of Elevated cAMP on Neutrophil Responses
V. Effect of cAMP on lntracellular Signals
VI. Altered Cyclic Nucleotide Responses in Disease
VII. Cyclic GMP in Neutrophils
VIII. Conclusion
References
Chapter 17. induction of Protein Phosphorylation during Leukocyte Activation
I. Introduction
II. Protein Serine/Threonine Kinases
III. Protein Tyrosine Kinases
IV. Lymphoid Cells and Phosphorylation
V. Myeloid Cell Activation
VI. Summary and Perspectives
References
Chapter 18. The Role of Phosphorylation in Phagocyte Activation
I. Introduction
II. Neutrophil Activation by PK-C
Ill. Phosphorylation Studies
IV. PK-C Activation of NADPH-Oxidase
V. Conclusion
References
Chapter 19. Activation of Lymphocytes by Lymphokines
I. Introduction
II. Lymphokines Are Nonspecific in Activity yet Function within a Specific Immune System
Ill. Pleiomorphic Function of Lymphokines
IV. Protein Structure
V. Gene Structure
VI. Lymphokine Receptors
VII. Lymphokines as Initiation and Progression Factors
VIII. Cell Activation
IX. Transmembrane Signaling by Lymphokines
X . Cross-Talk Between Antigen and Lymphokine Receptors
XI. Summary
References
Chapter 20. Role of Cytokines in Leukocyte Activation: Phagocytic Cells
I. Introduction
III. Major Cytokines
IV. Role of Cytokines in Neutrophil Activalion
V. Role of Cytokines in Macrophage-Monocytc Activation
VI. Summary: Cytokine Effects on Activation of Phagocytic Cells
References
Chapter 21. Protooncogene Expression following Lymphocyte Activation
I. Introduction
II. Altcrations in Oncogene Expression in Stimulated T Lymphocytes
III. Alterdtions in Protooncogene Expression in Stimulated B Lymphocytes
IV. Lyrnphocytc Activation Modulates Expression of the Ick Gene
V. Future Directions: The Underlying Complexity of Lymphocyte Activation
References
Chapter 22. Early Gene Expression in the Activation of Mononuclear Phagocytes
I. Introduction
II. Earlys Genes
III. Molccular Mechanisms of Macrophagc Activation
IV. Early Genes in Macrophage Activation
V. Conclusions and Future Directions
References
Index

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Current Topics in Membranes and Transport

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