
Cellular Response to the Genotoxic Insult
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Content
Part 1. Threshold effects observed in experimental studies: Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: implications for dose-response characteristics of mutagenic carcinogens;
Dose-effect relationships of DANN-reactive liver carcinogens;
DNA alkylation and repair after EEMS exposure: Where do the thresholds for mutagenic/clastogenic effects arise? Part 2. Metabolic inactivation of genotoxic reactants: Enzymatic detoxification of endogenously produced mutagenic carcinogens maintaining cellular homeostasis;
Phase 2 detoxifying enzymes and anti-oxygen defense mechanisms in the inactivation of genotoxic carcinogens;
Part 3. DNA repair: Consequences and Repair of oxidative DNA damage;
The plasticity of DNA damage response during cell differentiation: pathways and consequences;
Tumor suppressor protein-mediated regulation of base excision repair in response to DNA damage;
Part 4. Apoptosis: Survival and death strategies in cells exposed to genotoxin;
Different modes of cell death induced by DNA damage;
Transcriptional inhibition by DNA damage as a trigger of cell death;
Part 5. Epigenetic mechanisms: The interplay between epigenetics and Gap junctionional intercellular communication;
Index
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