CRISPR People
The Science and Ethics of Editing Humans
Published on 16. February 2021
400 pages
978-0-262-36273-3 (ISBN)
Description
What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us?
In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.
In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.
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Person
Henry T. Greely is Professor of Law, Professor by Courtesy of Genetics, and Director of the Stanford Center for Law and the Biosciences at Stanford University, where he also chairs the Steering Committee of the Stanford University Center for Biomedical Ethics and directs the Stanford Program in Neuroscience and Society.
Content
- Intro
- Contents
- Introduction
- I Background
- 1 Just What Did He Jiankui Do?
- 2 Human Germline Genome Editing-What Is It?
- "Human Germline Genome Editing"
- 3 CRISPR-What Is It, Why Is It Important, and Who Will Benefit from It?
- Naming of CRISPR
- 4 Ethics Discussions of CRISPR'd Babies before He
- Asilomar and the Ethics of Recombinant DNA
- The CRISPR Discussions
- 5 The Law of CRISPR'd Babies before He
- The Law of Human Subjects Research
- The Law of Medical Product Approval
- The Specific Law of Germline Genome Editing
- II The Revelation and Its Aftermath
- 6 The He Experiment Revealed
- Just before the Summit-Outside Hong Kong
- Just Before the Summit-in Hong Kong
- At the Summit
- 7 The World Reacts-And So Does China
- World Reactions
- Chinese Reactions
- 8 Who Knew What When? Revelations of Pre-Summit Knowledge
- Outside Academics Whom He Consulted
- Michael Deem
- Remaining Potential Revelations and Sources
- III Assessing and Responding to the He Experiment
- 9 Assessing the He Experiment
- The Risk/Benefit Ratio
- The Dubious Consent
- The Approval Process
- Transparency (or Opacity)
- International (Near) Consensus
- 10 Responses1
- The Inadequate Responses of Science
- Chinese Responses
- IV Human Germline Genome Editing Generally-NowWhat?
- 11 Is Human Germline Genome Editing Inherently Bad?
- The Three Reports
- My Perspective
- 12 Could Human Germline Genome Editing Sometimes Be Bad?
- 13 Just How Useful Is Human Germline Genome Editing?
- Editing Out Disease-Promoting Variations
- Editing in Disease-Preventing Variations
- Editing for Enhancement
- 14 How to Test Human Germline Genome Editing
- Preclinical Trials
- Clinical Trials
- Approval and Afterward
- 15 The Big Decisions-And How to Make Them
- Should Human Germline Genome Editing Be Completely Banned?
- Should Human Germline Genome Editing Be Regulated?
- How Should We Decide?
- Conclusion
- Acknowledgments
- Notes
- Introduction
- Chapter 1
- Chapter 2
- Chapter 3
- Chapter 4
- Chapter 5
- Chapter 6
- Chapter 7
- Chapter 8
- Chapter 9
- Chapter 10
- Chapter 11
- Chapter 12
- Chapter 13
- Chapter 14
- Chapter 15
- Conclusion
- Index
