
Electron Paramagnetic Resonance
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Content
- Electron Paramagnetic Resonance
- CONTENTS
- Preface
- Biomedical applications of EPR spectroscopy
- Introduction
- Reactive oxygen species
- Reactive nitrogen species
- Consequences of free radical reactions with biomolecules
- Damage to lipids
- Damage to DNA
- Damage to proteins
- Free radicals and disease
- Cancer
- Infectious disease
- Alzheimers disease
- Diabetes
- Cardiovascular disease
- Miscellaneous conditions
- Selected biomedical EPR techniques
- In vivo EPR oximetry
- In vivo EPR imaging
- References
- EPR studies of radiation damage to DNA and related molecules
- Introduction
- Scope of this report
- Recent trends in DNA radiation chemistry
- Symbols used
- DNA constituents
- Single crystal studies
- Amorphous systems
- DNA
- Track structure in DNA irradiated with heavy ions
- Studies of DNA-iron complexes
- Formation of 8-oxo-G in irradiated DNA by multiple one-electron oxidations
- Electron transfer versus differential fading of radicals
- Role of excited states in DNA damage-experimental and theoretical results
- Photoinduced radical formation in DNA
- DNA yields and strand breaks
- Electron induced cleavage of thymine dimers
- Acknowledgements
- References
- Measurement of interspin distances by EPR
- Introduction to distance determination
- Related reviews
- CW
- Accessibility to paramagnetic relaxation reagents
- Relaxation of free radicals due to nearby paramagnetic metals
- DEER (PELDOR)
- Determination of relative orientations of radicals in DEER
- More than two spins
- Uncertainty in distributions
- Metal-metal distances by DEER
- Limitations of the DEER method
- Examples of applications of DEER
- Other spin echo methods
- DQC and DEER
- Out-of-phase echo detection
- Biological studies at room temperature
- Sample preparation limitations
- Acknowledgements
- References
- Time-resolved electron paramagnetic resonance studies of transient organic radicals
- Introduction
- Photochemical applications
- Photoionization
- Photoreduction of sensitizers
- Photooxidation
- Homolytic bond scission
- Addition reactions to double bonds
- CIDEP studies
- Pulse radiolysis EPR
- Concluding remarks
- References
- EPR of paramagnetic centres on solid surfaces
- Introduction
- s-Block metal oxides
- Transition metal oxides
- TiO2
- ZrO2
- CeO2
- V2O5 Oxides
- CrOx Oxides
- MoOx Oxides
- Iron oxides
- Copper oxides
- ZnO
- p-Block metal oxides
- References
- EPR of exchange coupled oligomers
- Introduction
- p-Block
- d-Block
- Dimetallic complexes
- Trimetallic complexes
- Tetrametallic complexes
- Polymetallic complexes
- Polymetallic cores encapsulated into polyoxometalates
- Molecular wheels
- Single-molecule magnets (SMMs)
- Mixed p/d- and d/f-block
- Biological systems
- Methods
- Nitrogenases
- Copper
- Manganese (excluding photosystems)
- Diiron (including 2Fe2S)
- Other iron-sulfur centres
- Coupled haems
- Cobalt
- Photosystems
- Nickel
- References
- Continuous wave and pulsed EPR analyses of metalloproteins
- Introduction
- Field-swept EPR methods
- Detecting nuclear interactions
- Now you see it, now you don't
- Interpretation of EPR data
- Choosing between different experiments
- Example 1. The study of high-spin ferric heme proteins
- Example 2. The nickel-containing methyl-coenzyme M reductase
- Conclusion
- Acknowledgements
- References
- An EPR tool box for exploring the formation and properties of ordered template mesoporous materials
- Introduction
- Templated mesoporous materials
- The formation mechanism of TMM
- General principles
- Methods for mechanistic studies
- The formation of TMM with ionic templates
- The formation of TMM with non-ionic templates
- The EPR tool box
- Spin-probes
- The EPR experiments
- EPR investigation of the formation of TMM
- The location of the nitroxide label in micelles
- EPR studies of MCM-41
- EPR studies of SBA-15
- Studies of cubic mesoporous materials
- Studies of wormlike mesoporous materials
- Summary and outlook
- Acknowledgements
- References
- High-field pulse EPR instrumentation
- Introduction
- Scope of the review
- High-field EPR spectroscopy
- History of high-frequency pulse EPR
- Sensitivity
- Cavities
- Sensitivity and deadtime
- Measurement bandwidth
- Averaging and pulse repetition time
- St Andrews system design
- Current system performance
- System overview
- Induction mode cavities and sample holders
- Pulse sources and pulse generation
- Phase coherent detection system
- Spectrometer front end system design
- Control software
- Discussion
- Fourier transform EPR and FID detection
- Hyperfine and electron-dipolar spectroscopies
- Dynamic nuclear polarisation (DNP)
- Conclusions and outlook
- References
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