Cellular Therapy
Published on 30. January 2019
321 pages
978-1-77361-764-0 (ISBN)
Description
This book examines the current state and future prospects ofcell therapy. An essential guide to the data, basic science, outcomestudies and decision-making processes in blood and marrowstem cell transplantation. Stem cell research also involvescomplex ethical and legal considerations since they involveadult, foetal tissue and embryonic sources. The book providesa resource for students that will help them learn the basics in adetailed manner that is required for scientists and clinicians.
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Content
- Cover
- Half Title Page
- Title Page
- Copyright Page
- About the Authors
- Table of Contents
- List of Figures
- List of Tables
- Once the Idea, Today the Reality!
- Preface
- SECTION I: INTRODUCTION
- Chapter 1 Immunology and Cellular Therapies: An Overview
- 1.1. Historical Developments In Immunology
- 1.2. Overview of Immune System
- 1.3. Cells of Immune System
- 1.4. Antibodies
- 1.5. To Tap Immune Cells for Diagnostics and Therapy
- 1.6. Recent Advancements in Cellular Therapy
- References
- SECTION II PRACTICING CELLULAR THERAPIES
- Chapter 2 Regulatory Considerations in Practicing Cellular Therapies
- 2.1. Background
- 2.2. Reasons For The Controversies
- 2.3. An Approach Towards Regulatory Guidelines of Cellular as Well as Tissue-Based Products
- 2.4. Product Factors Affecting Each Area of Concern: An Overview
- 2.5. Regulatory Requirements For Minimally and More Than Minimally Manipulated HCT/PS
- 2.6. Future Directions
- 2.7. Summary
- References
- Chapter 3 Principles and Processes Required For The Development of Cellular Therapies
- 3.1. Introduction
- 3.2. The Benefits of Cellular Therapies
- 3.3. Defining The Status of Cellular Therapies: Proven/Unproven
- 3.4. Focusing on Unproven Cellular Therapies
- 3.5. Compassionate Use of Cell Therapy: Making The "Unproven" "Proven
- 3.6. Requirement And Challenges of Data Generation Associated With Unproven Cellular Therapies
- 3.7 Regulatory Concerns
- 3.8 Summary
- References
- SECTION III CELLS AND TISSUES FOR THERAPEUTIC USE FEW CONCEPTS AND CASE STUDIES
- Chapter 4 Bioengineering of Cells
- 4.1. Bioengineering of Embryonic Stem Cells
- 4.2. Bioengineering of Human Fetal Tissue Germ Cells
- 4.3. Bioengineering of Extra Embryonic Fetal Tissue Stem Cells
- 4.4. Tooth Stem Cell Engineering
- 4.5. Bioengineering of Limbus Stem Cells
- 4.6. Menstrual Blood Cells In Bioengineering
- 4.7. Skin Stem Cells And Bioengineering
- 4.8. Bioengineering of Hair
- 4.9. Summary
- References
- Chapter 5 Hematopoietic Progenitor Cellular Therapies
- 5.1. Introduction
- 5.2. Defining Hematopoietic Stem Cells
- 5.3. Transplantation Of Hematopoietic Stem Cells: Cell Therapy
- 5.4. Umbilical Cord Blood
- 5.5. Peripheral Blood For Cell Therapy
- 5.6. Case Study: Stem Cells of Bone Marrow Vs. Peripheral Blood as a Comparison: Clinical Trials
- 5.7. Summary
- References
- Chapter 6 Human Mesenchymal Stromal Cells
- 6.1. Introduction
- 6.2. Sources of Mesenchymal Cells
- 6.3. Culturing of MSCs
- 6.4. Markers of MSCs
- 6.5. Long-Term Storage of MSCs
- 6.6. Differentiation Ability of MSCs
- 6.7. MSCs And Diseases
- 6.8. Case Study: Mesenchymal Stem Cells And Porcine Hepatocytes
- 6.9. Summary
- References
- Chapter 7 Pancreatic Islets Cells
- 7.1. Introduction
- 7.2. Stem Cells
- 7.3. Islet Cell Transplants
- 7.4. Embryonic Stem (ES) Cells And Induced Pluripotent Stem (IPS) Cells
- 7.5. Pluripotent Stem Cell (PSCs) Transplant
- 7.6. ES Cell Therapy
- 7.7. Cell Therapy Via Adult Stem Cells
- 7.8. Regeneration of Pancreatic Islets
- 7.9. Summary
- References
- Chapter 8 Neural Stem Cells
- 8.1. Introduction
- 8.2. A Promising Tool: Cell Therapy Based on NSC Transplantation
- 8.3. Potential Optimization In Approach For Deriving Nsc and Challenges In Clinical Translation In NSC-Based Therapies
- 8.4. Summary
- References
- Chapter 9 Dendritic Cell Vaccines
- 9.1. Why Vaccines For Cancer?
- 9.2. Developing A Vaccine
- 9.3. Dendritic Cells
- 9.4. Dendritic Cell Vaccines
- 9.5. Future Directions
- 9.6. Summary
- References
- Chapter 10 Car T-Cell Therapy
- 10.1. Background
- 10.2. Immunotherapy
- 10.3. Tumor Antigens: The Targets
- 10.4. What Is Car T-Cell Therapy?
- 10.5. Structure of Car
- 10.6. Side Effects
- 10.7. Enhancing Car T-Cells Using Genetic Modification
- 10.8. Clinical Studies
- 10.9. The Road Ahead
- 10.10. Summary
- References
- Chapter 11 Bio-Repositories: A Concept
- 11.1. Introduction
- 11.2. Challenges In Biobanks
- 11.3. Case Studies of Biorepository: Cord Blood Banking
- 11.4. Summary
- References
- Chapter 12 Future Prospect of Cellular Therapy
- 12.1. Introduction
- 12.2. Current Status of Research And Clinical Trials In Cell Therapy
- 12.3. Current Status of Research And Clinical Trials In Regenerative Medicine
- 12.4. Genetically Engineered Stem Cells: Future Of Cell Therapy?
- 12.5. Cryopreservation And Banking
- 12.6. Perspectives Across The Globe Of Stem Cells And Cell Therapy
- 12.7. Summary
- References
- SECTION IV QUALITY ASSURANCE FOR IMPLEMENTING CELLULAR THERAPIES
- Chapter 13 Concepts and Requirements Of Quality Assurance In Cellular Therapies
- 13.1. Introduction
- 13.2. Evolution Of Cellular Therapy Quality Programs
- 13.3. Quality Assurance Resources
- 13.4. Quality Control
- 13.5. Conclusion
- References
- Index
