Cell Surface Receptors
Published on 14. May 2014
547 pages
978-0-08-049379-4 (ISBN)
Description
Cell Surface Receptors contains an extensive discussion of cell surface receptors in 11 chapters by experts in their field. As cell surface receptors are involved in almost every aspect of signaling throughout the body, the topic has been of high interest in the community in recent years.Selected Contents:
- Structures of Axon Guidance Molecules and Their Neuronal Receptors
- Shared Cytokine Signaling Receptor
- NKG2D and Related Immunoreceptors
- Inonotropic Glutamat Receptor Recognition and Activation
- Chemotaxis Receptors and Signaling
More details
Series
Language
English
Place of publication
San Diego
United States
Product notice
Windows
ISBN-13
978-0-08-049379-4 (9780080493794)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
K. Christopher Garcia
Cell Surface Receptors: Volume 68
Book
12/2004
Academic Press
€142.60
Shipment within 15-20 days
Content
- Cover
- Contents
- Preface
- Chapter 1. Structure and Function of the Epidermal Growth Factor (EGF/ErbB) Family of Receptors
- I. Introduction
- II. The EGF and EGFR Families
- III. Association of ErbB Receptors with Human Disease
- IV. Structure of Individual ErbB Receptor Domains
- V. Structure of Entire ErbB Receptor Ectodomains
- VI. HER2
- VII. Therapeutic Anti-HER2 Antibodies
- VIII. Remaining Questions
- References
- Chapter 2. The Three-Dimensional Structure of Integrins and Their Ligands, and Conformational Regulation of Cell Adhesion
- I. Introduction
- II. Conformational Regulation of Integrin Structure and Function
- III. Integrin/Ligand Interactions
- References
- Chapter 3. Structures of Axon Guidance Molecules and Their Neuronal Receptors
- I. Introduction
- II. Eph Receptors and Ephrins
- III. Semaphorins, Neuropilins, and Plexins
- IV. Myelin-Associated Inhibitors of Axonal Regeneration
- V. Conclusion and Perspectives
- References
- Chapter 4. Shared Cytokine Signaling Receptors: Structural Insights from the gp130 System
- I. Cross-Reactive Signaling Receptors in Biology
- II. Cytokines and Receptors
- III. The Growth Hormone Paradigm: Generalities and Limitations
- IV. Shared Signaling Receptors for Hematopoietic Cytokines
- V. gp130 Family of Cytokines and Receptors
- VI. A Structural Basis of gp130 Cross Reactivity: Site II
- VII. Thermodynamic Basis for a Universal Binding Solution
- VIII. Cross-Reactivity of the gp130 IGD with Cytokine Site III
- IX. Predicting the Higher-Order Assemblies of the Asymmetric Complexes (gp130/LIFR)
- X. Translating Ligand Recognition into Signaling
- References
- Chapter 5. The Structural Basis for Biological Signaling, Regulation, and Specificity in the Growth Hormone-Prolactin System of Hormones and Receptors
- I. Structural Basis for Receptor Homodimerization
- II. Hormone Receptor Binding Sites
- III. Hormone-Receptor Binding Energetics: The Binding ''Hot-Spot'' Concept
- IV. Stereoselectivity of the Prolactin Receptor (hPRLR)
- V. Comparison of the hGH Site1 and Site2 Binding Energy Epitopes in the hGH-hGHR Ternary Complex
- VI. Protein Engineering to Create New Properties
- VII. Allosteric Effects, A Big Surprise
- VIII. Biological Implications of Transient Receptor Dimerization
- IX. Mechanism of ECD2 Binding, the Regulation Step in Biological Signaling
- X. Future Directions
- References
- Chapter 6. Structural Analysis of IL-10 and Type I Interferon Family Members and Their Complexes with Receptor
- I. Introduction
- II. Structures of the HCIIs
- III. Structures of the Class 2 Homology Region (C2HR)
- IV. Structure of the High-Affinity HCII/C2HR Interfaces
- V. Concluding Remarks
- References
- Chapter 7. Assembly of Post-Receptor Singnaling Complexes for the Tumor Necrosis Factor Receptor Superfamily
- I. Introduction
- II. Domain and Oligomeric Structures of TRAFs
- III. TRAF2-Receptor Interactions: Establishment of the Paradigm
- IV. TRAF3-Receptor Interactions: Similarities and Differences with TRAF2
- V. TRAF6-Receptor Interactions: Distinct Specificity
- VI. Thermodynamics of TRAF-Receptor Interactions
- VII. TRAF2-TRADD Interaction: A Novel Mode of TRAF Signaling
- VIII. TRAF Signaling Inhibitors
- IX. DD and DD-DD Interactions
- X. Conclusion: Emerging Principles of Post-Receptor Signal Transduction
- References
- Chapter 8. NKG2D and Related Immunoreceptors
- I. T Cell Receptors and MHC Class I Proteins: Paradigms of Immunological Recognition
- II. NK Cells and Receptors
- III. NKG2x NK Cell Receptors
- IV. HuNKG2D Ligands: MIC-A/B
- V. HuNKG2D Ligands: ULBPs
- VI. MuNKG2D Ligands: RAE-1s, H60, and MULT1
- VII. NKG2D-Ligand Complexation
- VIII. NKG2D-Ligand Recognition Degeneracy: ''Rigid Adaptation'' Rather Than ''Induced-Fit''
- IX. NKG2D: Open Questions
- X. NKG2D: Implications for NKG2x-CD94 Recognition
- XI. MIC and yd TCRs
- References
- Chapter 9. Ionotropic Glutamate Receptor Recognition and Activation
- I. Introduction
- II. Beginnings of Structure: Cloning, Mutagenesis, Transmembrane Topology, and Homology Models
- III. The Amino Terminal Domain (ATD)
- IV. Structure and Dynamics of the Glutamate-Binding Domain
- V. Structure of the Ion Channel
- VI. The C-Terminal Domain
- VII. Relating Structure, Function, and Dynamics: Channel Gating and Desensitization
- VIII. Evolution of Glutamate Receptors
- IX. Summary
- References
- Chapter 10. Chemokine-Receptor Interactions: GPCRs, Glycosaminoglycans and Viral Chemokine Binding Proteins
- I. Introduction
- II. The Chemokine Superfamily
- III. Interaction of Chemokines and Glycosaminoglycans
- IV. Viral Chemokines and Receptors, Chemokine Mimics, and Chemokine Binding Proteins
- V. Chemokines and Disease
- References
- Chapter 11. Chemotaxis Receptors and Signaling
- I. Introduction to Chemotaxis
- II. Signal Transduction Events
- III. G Protein-Coupled Receptors
- IV. Conserved Elements of GPCR Structure
- V. Rhodopsin Structure
- VI. Proposed GPCR Activation Mechanisms
- VII. Activation Mechanisms of Specific Chemotaxis GPCRs
- VIII. Receptor Oligomerization
- IX. Conclusions
- References
- Author Index
- Subject Index
- Color Plate Section
