Normal and Malignant Cell Growth
Recent Results in Cancer Research: Fortschritte der Krebsforschung, Progrès dans les Recherches sur le Cancer
Published on 12. May 2014
252 pages
978-1-4832-2366-7 (ISBN)
Description
Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.
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Content
PrefaceIntroductionList of ParticipantsNormal Cell Kinetics General Introduction Proliferative Capacity of Hemopoietic Stem Cells Discussion: Colony Forming Units in the Bone Marrow of Partial Body Irradiated Mice Cellular Proliferation in the Liver Discussion: Cellular Proliferation in the Liver Cell Proliferation in the Intestinal Epithelium Discussion: Proliferation of Gastrointestinal Cells General Discussion Proliferation of Antibody Forming Cells Discussion: Proliferation of Antibody Forming Cells Composition of Cell Life Cycle Discussion: Methods and Criteria of Mammalian Cell Synchrony Susceptibility of Intestinal Crypt Epithelium to Hydroxyurea and Other Antitumor Agents Discussion: Mammalian Cell Killing by Inhibitors of DNA SynthesisProliferation of Cancer Cells General Introduction: The Growth of Tumor Cells under Normal and Fasting Conditions Cell Proliferation during Carcinogenesis Comparison Between the Rates of Proliferation of Induced Malignancies and Their Normal Tissues of Origin The Use of Three-Dimensional Matrix Tissue Culture for Bioassay of Cancer Discussion: The Use of Three-Dimensional Matrix Tissue Culture for Bioassay of Cancer Importance of the Non-Dividing Leukemia Cell Discussion: Magnitude of Proliferating Fraction and Rate of Proliferation of Populations of Leukemic Cells in Man Incorporation of Iodine-Labeled 5-Iodo-2'-Deoxyuridine into D N A of Mouse Mammary Tumors In Vivo Cell Kinetics of Human Cancers Summary: H. M. PATT Round-Table Discussion
