
Human Metabolism
Description
Alles über E-Books | Antworten auf Fragen rund um E-Books, Kopierschutz und Dateiformate finden Sie in unserem Info- & Hilfebereich.
The updated bestselling guide to human metabolism and metabolic regulation
The revised and comprehensively updated new edition of Human Metabolism (formerly Metabolic Regulation - A Human Perspective) offers a current and integrated review of metabolism and metabolic regulation. The authors explain difficult concepts in clear and concise terms in order to provide an accessible and essential guide to the topic. This comprehensive text covers a wide range of topics such as energy balance, body weight regulation, exercise, and how the body copes with extreme situations, and illustrates how metabolic regulation allows the human body to adapt to many different conditions.
This fourth edition has been revised with a new full colour text design and helpful illustrations that illuminate the regulatory mechanisms by which all cells control the metabolic processes necessary for life. The text includes chapter summaries and additional explanatory text that help to clarify the information presented. In addition, the newly revised edition includes more content on metabolic pathways and metabolic diseases. This important resource:
- Is a valuable tool for scientists, practitioners and students across a broad range of health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing
- Includes a full colour text filled with illustrations and additional diagrams to aid understanding
- Offers a companion website with additional learning and teaching resources.
Written for students of medicine, biochemistry, nutrition, dietetics, sports science and nursing, Human Metabolism has been revised and updated to provide a comprehensive review of metabolism and metabolic regulation.
More details
Other editions
Additional editions

Persons
Keith N. Frayn, Emeritus Professor of Human Metabolism, University of Oxford, UK.
Rhys D. Evans, Reader in Metabolic Biochemistry, Department of Physiology, Anatomy and Genetics, University of Oxford, UK.
Content
Preface vi
Abbreviations vii
About the companion website xi
1 The underlying principles of human metabolism 1
2 Cellular aspects of metabolic regulation 48
3 Coordination of metabolism in the whole body 76
4 Digestion and intestinal absorption 93
5 Metabolic specialisation of organs and tissues 118
6 Communication systems 173
7 Integration of carbohydrate, fat and protein metabolism in normal daily life 204
8 Metabolic challenges: Coping with some extreme physiological situations 245
9 Metabolic challenges: Coping with some pathological situations 277
10 Lipoprotein metabolism and atherosclerosis 302
11 Energy balance and body weight regulation 325
12 Diabetes mellitus 346
Index 365
Abbreviations
Some abbreviations used only within a figure, table or box, and defined there, are not included here. Some abbreviations are given in the text not because the terms are used frequently, but because the substance in question is often better known by its abbreviation. In such cases, if the abbreviation only occurs in one limited section, it will not be listed here.
ABC (G5, G8, etc.) ATP-binding cassette-containing protein-G5, G8 etc. ACAT acyl-Coenzyme A: cholesterol acyltransferase ACC acetyl-CoA carboxylase ACCORD Action to Control Cardiovascular Risk in Diabetes ACE angiotensin-converting enzyme ACS acyl-CoA synthase ACSL long-chain acyl-CoA synthase ACTH adrenocorticotrophic hormone (corticotrophin) ADH antidiuretic hormone ADP adenosine 5´-diphosphate AEE activity energy expenditure AGE advanced glycation end-product AgRP Agouti-related protein AIDS Acquired ImmunoDeficiency Syndrome ALT alanine aminotransferase AMP adenosine 5´-monophosphate AMPK AMP-activated protein kinase ANP atrial natriuretic peptide APOA, B, C, E, etc. apolipoprotein A,B,C,E, etc. ARB angiotensin receptor blocker AST aspartate aminotransferase ATGL adipose triacylglycerol (or triglyceride) lipase ATP adenosine 5´-trisphosphate BAT brown adipose tissue BCAA branched chain amino acid BCAT branched chain amino acid aminotransferase BCKD(C) branched chain 2-oxoacid (a-ketoacid) dehydrogenase (complex) BMCP1 brain mitochondria carrier protein 1 BMI body mass index BMR basal metabolic rate BNP brain natriuretic peptide cAMP cyclic adenosine 3´, 5´-monophosphate (cyclic AMP) CARS compensatory anti-inflammatory response syndrome CAT-1, 2 carnitine-acyl transferase-1, 2 CCK cholecystokinin CETP cholesteryl ester transfer protein cGMP cyclic guanosine 3´, 5´-monophosphate (cyclic GMP) CHD coronary heart disease ChRE carbohydrate response element ChREBP carbohydrate response element binding protein CIM critical illness myopathy CIP critical illness polyneuropathy CNP C-type natriuretic peptide CNS central nervous system CoA coenzyme A CoASH coenzyme A reduced form CoQ10 ubiquinone CPT-1, 2 carnitine-palmitoyl transferase-1, 2 CSII continuous subcutaneous insulin infusion DHA docosahexaenoic acid (22 : 6 n-3) D-2HG D-2-hydroxyglutarate DIT diet-induced thermogenesis DPP Diabetes Prevention Program EDRF endothelial-derived relaxing factor EE energy expenditure eIF eukaryotic initiation factor eNOS endothelial NO synthase ER endoplasmic reticulum ERK extracellular signal-regulated kinase FABP(pm) fatty acid binding protein (plasma membrane isoform) FAD flavin adenine dinucleotide (oxidised form) FADH2 flavin adenine dinucleotide (reduced form) FAT fatty acid translocase FATP fatty acid transport protein FFM fat-free mass FGF fibroblast growth factor FH familial hypercholesterolaemia FIL feedback inhibitor of lactation FoxO Forkhead box 'Other' FQ food quotient FSH follicle-stimulating hormone FXR farnesoid X-receptor G Gibbs 'free' energy G6-P glucose 6-phosphate GDP guanosine 5´-diphosphate GH growth hormone GHSR growth hormone secretagogue receptor GIP gastric inhibitory polypeptide, also known as glucose-dependent insulinotrophic polypeptide GK glucokinase GLP (1 and 2) glucagon-like peptide-1 and -2 GLUT glucose transporter GOAT ghrelin-O-acyltransferase GPAT glycerol phosphate-acyl transferase GPCR G protein-coupled receptor GPIHBP1 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 GR glucocorticoid receptor GSK glycogen synthase kinase GTP guanosine 5´-trisphosphate HDAC histone deacetylation/deacetylase HDL high density lipoprotein HIF-1 hypoxia-inducible factor-1 HIV Human Immunodeficiency Virus HK hexokinase HMG-CoA 3-hydroxy-3-methylglutaryl-CoA hPL human placental lactogen HSL hormone-sensitive lipase 5-HT 5-hydroxytryptamine IDDM insulin-dependent diabetes mellitus IGF insulin-like growth factor IL interleukin IMM inner mitochondrial membrane JAK originally Just Another Kinase; redesignated JAnus Kinase Ka dissociation constant for an acid Km Michaelis constant LADA latent autoimmune diabetes in adults LCAD long-chain acyl CoA dehydrogenase LCAT lecithin-cholesterol acyltransferase LDL low-density lipoprotein LH luteinising hormone LPL lipoprotein lipase LXR liver X-receptor MAPK mitogen-activated protein kinase MET (unit of work): 1 MET =...System requirements
File format: ePUB
Copy protection: Adobe-DRM (Digital Rights Management)
System requirements:
- Computer (Windows; MacOS X; Linux): Install the free reader Adobe Digital Editions prior to download (see eBook Help).
- Tablet/smartphone (Android; iOS): Install the free app Adobe Digital Editions or the app PocketBook before downloading (see eBook Help).
- E-reader: Bookeen, Kobo, Pocketbook, Sony, Tolino and many more (not Kindle).
The file format ePub works well for novels and non-fiction books – i.e., „flowing” text without complex layout. On an e-reader or smartphone, line and page breaks automatically adjust to fit the small displays.
This eBook uses Adobe-DRM, a „hard” copy protection. If the necessary requirements are not met, unfortunately you will not be able to open the eBook. You will therefore need to prepare your reading hardware before downloading.
Please note: We strongly recommend that you authorise using your personal Adobe ID after installation of any reading software.
For more information, see our ebook Help page.