The Mouse in Biomedical Research
Normative Biology, Immunology, and Husbandry
1st Edition
Published on 10. May 2014
464 pages
978-1-4832-6276-5 (ISBN)
Description
The Mouse in Biomedical Research, Volume III: Normative Biology, Immunology, and Husbandry focuses on the normative biology, immunology, and husbandry of laboratory mice. Topics covered range from gnotobiotics and gastrointestinal microflora to animal health surveillance and health delivery systems, along with environmental monitoring. The management and design of breeding and research facilities are also discussed. Comprised of 18 chapters, this volume begins with an overview of studies involving gnotobiotic mice, the induction of gnotobiosis, and microbiological testing of gnotobiotic animals. Maintenance of breeding colonies of gnotobiotic animals is also considered, together with the shipment of gnotobiotes and laboratory facilities for using gnotobiotes. The reader is then introduced to management and design of breeding and research facilities for gnotobiotic mice; practical factors associated with providing adequate nutrition for laboratory mice; and environmental and equipment monitoring. Subsequent chapters deal with the basic biology of the mouse, including anatomy, embryology, reproductive physiology, physiology, endocrinology, hematology, clinical biochemistry, and gastrointestinal microflora. The book also examines immunoglobulins and immunoglobulin genes; lymphocyte immunogenetics; immune response disorders; and biomethodology and surgical techniques. This monograph will be useful to biologists, immunologists, researchers, and others those who use mice in the laboratory or are concerned with the production and maintenance of colonies of mice.
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Other editions
Additional editions
Henry L. Foster | etc.
The Mouse in Biomedical Research: Normative Biology, Immunology and Husbandry v. 3
Book
05/1983
Academic Press
€157.22
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Content
¿List of ContributorsForewordPrefaceList of Reviewers for Chapters in This VolumeChapter 1 Gnotobiotics I. Introduction II. Sterile Environment III. Induction of Gnotobiosis IV. Microbiological Testing V. Maintenance of Breeding Colonies VI. The Shipment of Gnotobiotes VII. Laboratory Facilities for Using Gnotobiotes ReferencesChapter 2 Management and Design of Breeding Facilities I. Introduction II. Facility Design and Management III. Environmental Management Factors IV. Management and Husbandry V. Conclusions and Summary ReferencesChapter 3 Design and Management of Research Facilities for Mice I. Introduction II. Facility Design and Management III. Environmental Factors to Be Considered in Design and Management IV. Conclusions ReferencesChapter 4 Nutrition I. Introduction II. Nutrient Requirements III. Factors Affecting Nutrient Requirements IV. Required Nutrients V. Classification of Diets VI. Considerations in Diet Selection VII. Diet Formulation VIII. Diet Manufacture IX. Physical Forms of Mouse Diets X. Diet Storage XI. Biological Contaminants ReferencesChapter 5 Animal Health Surveillance and Health Delivery Systems I. Introduction II. Evaluation of Incoming Mice III. Methods of Disease Detection IV. Interpretation of Findings V. Medical Action VI. Impact on Research VII. Summary ReferencesChapter 6 Environmental and Equipment Monitoring I. Introduction II. Management III. Environmental Factors IV. Equipment and Systems V. Feed and Bedding VI. Sanitation VII. Monitoring for Pests VIII. Conclusion ReferencesChapter 7 Anatomy I. Introduction II. External Features III. Skeleton IV. Muscular System V. Nervous System VI. Cardiovascular System VII. Lymph Nodes VIII. Respiratory System IX. Gastrointestinal System X. Urinary System XI. Male Genital System XII. Female Genital System XIII. Endocrine Organs XIV. Other Organs XV. Organ Weights ReferencesChapter 8 Embryology I. Preimplantation II. Implantation III. Differentiation IV. Development of the Placenta V. Staging of Embryos ReferencesChapter 9 Reproductive Physiology I. Introduction II. Determination of Sex III. Gametogenesis IV. Puberty V. Mating VI. Initiation of Development VII. Implantation VIII. Pregnancy IX. Parturition X. Lactation XI. Litter Size XII. Reproductive Life Span XIII. Environmental Influences XIV. Techniques in Reproductive Physiology ReferencesChapter 10 Endocrinology I. Introduction II. Pituitary Gland III. Thymus Gland IV. Thyroid Gland V. Parathyroid Glands VI. Endocrine Pancreas VII. Adrenal Gland VIII. Kidney IX. Ovary X. Testis ReferencesChapter 11 Physiology I. The Cardiovascular System II. Respiratory Physiology III. The Digestive System IV. Metabolism V. Thermoregulation VI. Renal Physiology VII. Water Regulation VIII. Neurophysiology ReferencesChapter 12 Hematology I. Developmental Aspects II. Hemopoiesis and Stem Cell Function III. The Erythron IV. Blood Volume V. Biochemical Aspects VI. White Cells VII. Platelets VIII. Coagulation ReferencesChapter 13 Clinical Biochemistry I. Introduction II. Factors Affecting the Results of Clinical Chemical Assays III. Determination of Reference Ranges IV. Application of Clinical Biochemistry: Preclinical Toxicology V. Interpretative Clinical Biochemistry VI. Trends and Future Developments ReferencesChapter 14 Gastrointestinal Microflora I. Introduction II. Succession of Bacterial Populations in the Gastrointestinal Tract of the Mouse III. The Phenomenon of Adherence IV.
