Basic Pharmacology

Preface Introduction List of Abbreviations 1 General Pharmacology Mechanisms of Drug Action Receptor Mediation of Drug Effects Adverse Effects of Drugs Allergically Determined Hypersensitivity to Drugs Genetically Determined Idiosyncracy to Drugs (Pharmacogenetics) Developmental Toxicity Adverse Drug Interactions Abuse of Drugs Drug Design, Development and Testing 2 Drug Action on Peripheral Excitable Tissues - Drugs Acting on Signaling and Transduction Mechanisms Directly Related to Receptors for the Neurotransmitters Acetylcholine and Noradrenaline The Efferent Peripheral Nervous System The Effector Cells Innervated By Postganglionic Autonomic Neurones The Pharmacology of Cholinergic Axons and Their Terminals The Pharmacology of the Cholinoceptors of Skeletal Muscle The Pharmacology of the Cholinoceptors of Ganglia The Pharmacology of the Cholinoceptors of Smooth Muscle, Cardiac Muscle and Exocrine Glands Cholinesterases and Their Inhibitors Noradrenergic Neuroeffector Transmission as Target of Drug Action Drugs with Noradrenergic Prejunctional Sites of Action Drugs That Modify the Release of Noradrenaline Drugs That Modify the Inactivation of Noradrenaline Agonists at Adrenoceptors Antagonists at Adrenoceptors The Adrenal Medulla 3 Drug Action on Peripheral Tissues - Drugs Acting on Signaling and Transduction Mechanisms Other than Those Directly Related to Receptors for Neurotransmitters and Hormones Local Anaesthesia Cardiac Antidysrhythmic Drugs Cardiac Glycosides Calcium Channel Blockers Methylxanthines Nitrates Diuretics Anticoagulant, Antithrombotic and Fibrinolytic Compounds Lipid-Lowering Drugs 4 Endocrine Pharmacology Hypothalamo-Pituitary Axis Gonadotrophins Oestrogens, Progestogens and Androgens The Thyroid Gland and Drugs Used in Thyroid Abnormalities The Adrenal Cortex and the Corticosteroids Drugs in Diabetes Mellitus Posterior Pituitary Hormones Angiotensin Local Hormones Inflammation 5 Drug Action on the Central Nervous System Chemical Transmission in the CNS Extrapyramidal Disorders of Movement Antidepressive Drugs Antipsychotic Drugs Vomiting, Emetics and Antiemetics Opioid Analgesics and Their Antagonists Stimulants and Hallucinogens Antipyretic Analgesics The State of Consciousness and the General Anaesthetic Agents 6 Antiparasitic Chemotherapy Biochemical Selectivity Distributional Selectivity Drug Resistance in Parasites Chemotherapy of Metazoal Infestations Chemotherapy of Protozoal Infections Chemotherapy of Fungal Infections Chemotherapy of Bacterial Infections Chemotherapy of Viral Infections Chemotherapy of Malignant Neoplasms 7 Drug Disposition Absorption Distribution Elimination Pharmacokinetics Drug Dosage Regimens Physicochemical Groupings of Drugs Water-Soluble Drugs Drugs with Intermediate Solubility Lipid-Soluble Drugs Acidic Drugs Basic Drugs 8 Clinical Pharmacology Acute Poisoning Peptic Ulceration Inflammatory Bowel Disease Gastrointestinal Motility Disorders Congestive Heart Failure Hypertension and Antihypertensive Drugs Angina of Effort Asthma Coughs and Colds Headache and Migraine Drugs and Mental Disorders Epilepsy Drugs and Fertility Haematinic Drugs and the Cellular Elements of Blood Drugs in Joint Disease Drugs and the Skin Suggested Further Reading Index