Bioinformatics for Immunomics
1st Edition
Published on 3. October 2009
XVI, 192 pages
978-1-4419-0540-6 (ISBN)
Description
Like many words, the term "immunomics" equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism - be that virus, bacteria, fungus, or parasite - or microbial population, or antigenic or allergenic proteins and peptides derived from the environment as a whole, containing also proteins from eukaryotic sources. However, times have changed and the meaning of immunomics has also changed. Other newer definitions of the Immunome have come to focus on the plethora of immunological receptors and accessory molecules that comprise the host immune arsenal. Today, Immunomics or immunogenomics is now most often used as a synonym for high-throughput genome-based immunology. This is the study of aspects of the immune system using high-throughput techniques within a conc- tual landscape borne of both clinical and biophysical thinking.
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Darren D.R. Flower | Matthew Davies | Shoba Ranganathan
Bioinformatics for Immunomics
Book
11/2009
Springer
€213.99
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Content
Computational Vaccinology.- The Immuno Polymorphism Database.- The IMGT/HLA Database.- Ontology Development for the Immune Epitope Database.- TEPIDAS: A DAS Server for Integrating T-Cell Epitope Annotations.- Databases and Web-Based Tools for Innate Immunity.- Structural Immunoinformatics: Understanding MHC-Peptide-TR Binding.- Discovery of Conserved Epitopes Through Sequence Variability Analyses.- Tunable Detectors for Artificial Immune Systems: From Model to Algorithm.- Defining the Elusive Molecular Self.- A Bioinformatic Platform for a Bayesian, Multiphased, Multilevel Analysis in Immunogenomics.
