Circulating Tumor Cells
Isolation and Analysis
Published on 25. March 2016
464 pages
978-1-119-24454-7 (ISBN)
Description
Introduces the reader to Circulating Tumor Cells (CTCs), their isolation method and analysis, and commercially available platforms
* Presents the historical perspective and the overview of the field of circulating tumor cells (CTCs)
* Discusses the state-of-art methods for CTC isolation, ranging from the macro- to micro-scale, from positive concentration to negative depletion, and from biological-property-enabled to physical-property-based approaches
* Details commercially available CTC platforms
* Describes post-isolation analysis and clinical translation
* Provides a glossary of scientific terms related to CTCs
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Book
05/2016
Wiley
€154.50
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Software
04/2016
Wiley
€119.71
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Persons
Z. Hugh Fan, PhD, is a professor of the Department of Mechanical and Aerospace Engineering, J. Crayton Pruitt Family Department of Biomedical Engineering, and Department of Chemistry at the University of Florida (UF), USA. Prior to joining UF in 2003, Dr. Fan was a Principal Scientist at ACLARA BioSciences Inc. and was previously a Member of the Technical Staff at Sarnoff Corp. Dr. Fan has been recognized with E.T.S. Walton Award from Science Foundation of Ireland in 2009, Fraunhofer-Bessel Research Award from Alexander von Humboldt Foundation (Germany) in 2010, and UF Research Foundation Professorship in 2014.
Content
Preface
Part I Introduction
1 Circulating tumor cells and historic perspectives
Jonathan W. Uhr
2 Introduction to microfluidics
Kangfu Chen, Z. Hugh Fan
Part II Isolation Methods
3 Ensemble-decision Aliquot Ranking (eDAR) for CTC Isolation and Analysis
Mengxia Zhao, Perry G. Schiro, Daniel T. Chiu
4 Sinusoidal Microchannels with High Aspect Ratios for CTC Selection and Analysis
Joshua M. Jackson, Steven A. Soper, Malgorzata A. Witek
5 Cell Separation Using Inertial Microfluidics
Nivedita Nivedita, Ian Papautsky
6 Morphological Characteristics of CTCs and the Potential for Deformability-based Separation
Simon P. Duffy, Hongshen Ma
7 Microfabricated filter membranes for capture and characterization of Circulating Tumor Cells
Zheng Ao, Anthony Williams, Richard J. Cote, Ram H. Datar
8 Miniaturized Nuclear Magnetic Resonance Platform for Rare Cell Detection and Profiling
Sangmoo Jeong, Changwook Min, Huilin Shao, Arezou Ghazani, Cesar M. Castro, Ralph Weissleder, Hakho Lee
9 NanoVelcro Cell-Affinity Assay for Detection and Characterization of Circulating Tumor Cells
An-Jou Liang, Anna Fong, Hsian-Rong Tseng, Jie-fu Chen, Millicent Lin, Min Song, Morgan Fong, Qingyu Li, Shang-Fu Chen, Sharon Chen, Shuang Hou, Yang Zhang, Zunfu Ke
10 Acoustophoresis for tumor cell enrichment
Thomas Laurell, Per Augustsson, Cecilia Magnusson, Hans Lilja
11 Photoacoustic flow cytometry for detection and capture of circulating melanoma cells
John A. Viator, Benjamin S. Goldschmidt, Kiran Bhattacharyya, Kyle Rood
12 Selectin-Mediated Targeting of Circulating Tumor Cells for Isolation and Treatment
Jocelyn Marshall, Michael King
13 Aptamers-enabled tumor cell isolation
Jinling Zhang, Z. Hugh Fan
14 Depletion of normal cells for CTC enrichment
Jeffrey J. Chalmers, Maryam B. Lustberg, Clayton Deighan, Kyoung-Joo Jenny Park, Yongqi Wu, Peter Amaya
Part III Post-Isolation Analysis and clinical translation
15 Tumor heterogeneity and single cell analysis of CTCs
Evelyn Kidess Sigal, Stefanie S. Jeffrey
16 Single-cell molecular profiles and biophysical assessment of circulating tumor cells
Chun-Liang Chen, Maria E. Gaczynska, Aaron M. Horning, Chun-Lin Lin, Anna D. Louis, Devalingam Mahalingam, Pawel Osmulski, Chiou-Miin Wang
17 Directing Circulating Tumor Cell Technologies into Clinical Practice
Benjamin P Casavant, David T Kosoff, Joshua M Lang
Part IV Commercialization
18 DEPArray(TM) Technology for Single CTC-analysis
Farideh Z. Bischoff, Nicolò Manaresi, Gianni Medoro
19 CELLSEARCH® instrument, features, and usage
Denis A. Smirnov, Brad W. Foulk, Mark C. Connelly, Robert T. McCormack
Glossary
Jose Varillas, Z. Hugh Fan
Index
List of Contributors
- Peter Amaya William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA
- Zheng Ao Sheila and David Fuente Graduate Program in Cancer Biology, Department of Pathology and Laboratory Medicine, Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute, University of Miami Miller School of Medicine, Miami, FL, USA
- Per Augustsson Department of Biomedical Engineering, Lund University, Lund, Sweden
- Kiran Bhattacharyya Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
- Farideh Z. Bischoff Silicon Biosystems, Inc., San Diego, CA, USA
- Benjamin P. Casavant Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA
- Cesar M. Castro Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
- Jeffrey J. Chalmers William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA
- Chun-Liang Chen Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
- Jie-fu Chen Urologic Oncology Research Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
- Kangfu Chen Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA
- Shang-Fu Chen Department of Life Science, National Taiwan University, Taipei City, Taiwan (ROC)
- Sharon Chen Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Daniel T. Chiu Department of Chemistry, University of Washington, Seattle, WA, USA
- Mark C. Connelly Oncology Biomarkers, Janssen R&D, Huntingdon Valley, PA, USA
- Richard J. Cote Department of Pathology and Laboratory Medicine, Department of Biochemistry and Molecular Biology, Department of Pathology, Jackson Memorial Hospital, Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute, University of Miami Miller School of Medicine, Miami, FL, USA
- Ram H. Datar Department of Pathology and Laboratory Medicine, Department of Biochemistry and Molecular Biology, Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute, University of Miami Miller School of Medicine, Miami, FL, USA
- Clayton Deighan William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA
- Paulina Do Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Simon P. Duffy Department of Mechanical Engineering, University of British Columbia, Vancouver, British Columbia, Canada
- Z. Hugh Fan Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA; Department of Chemistry, University of Florida, Gainesville, FL, USA
- Anna Fong Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Morgan Fong Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Brad W. Foulk Oncology Biomarkers, Janssen R&D, Oncology Biomarkers, Spring House, PA, USA
- Maria E. Gaczynska Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
- Benjamin S. Goldschmidt Department of Bioengineering, University of Missouri, Columbia, MO, USA
- Aaron M. Horning Integrated Biomedical Science Graduate Program, University of Texas Health Science Center, San Antonio, TX, USA
- Shuang Hou Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Joshua M. Jackson Department of Chemistry, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
- Stefanie S. Jeffrey Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
- Sangmoo Jeong Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
- Michael R. King Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA
- David Kosoff Department of Medicine, University of Wisconsin, Madison, WI, USA
- Joshua M. Lang Department of Medicine, University of Wisconsin Carbone Cancer Center, Madison, WI, USA
- Thomas Laurell Department of Biomedical Engineering, Lund University, Lund, Sweden
- Hakho Lee Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
- Qingyu Li Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- An-Jou Liang Department of Life Science, National Taiwan University, Taipei City, Taiwan (ROC)
- Hans Lilja Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- Chun-Lin Lin Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
- Millicent Lin Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Anna D. Louie School of Medicine, University of Nevada, Reno, NV, USA
- Maryam B. Lustberg Stefanie Spielman Comprehensive Breast Center, Wexner Medical Center, The Ohio State University, Columbus, OH, USA
- Hongshen Ma Department of Mechanical Engineering, University of British Columbia, Vancouver, British Columbia, Canada; Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada; Department of Urologic Science, University of British Columbia, Vancouver, British Columbia, Canada
- Cecilia Magnusson Department of Translational Medicine, Lund University, Lund, Sweden
- Devalingam Mahalingam Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
- Nicolò Manaresi Silicon Biosystems, SpA, Bologna, Italy
- Jocelyn R. Marshall Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA
- Robert T. McCormack Oncology Biomarkers, Janssen R&D, Raritan, NJ, USA
- Gianni Medoro Silicon Biosystems, SpA, Bologna, Italy
- Changwook Min Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
- Nivedita Nivedita Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, OH, USA
- Pawel Osmulski Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
- Klaus Pantel Department of Tumour Biology, Center of Experimental Medicine, University Cancer Center Hamburg, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
- Ian Papautsky Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, OH, USA
- Kyoung-Joo J. Park William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA
- Kyle Rood Biodesign Program, One Hospital Drive, Columbia, MO, USA
- Perry G. Schiro MiCareo Inc., Taipei, Taiwan
- Huilin Shao Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
- Evelyn K. Sigal Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
- Denis A. Smirnov Oncology Biomarkers, Janssen R&D, Oncology Biomarkers, Spring House, PA, USA
- Min Song Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Steven A. Soper Department of Chemistry, University of North Carolina Chapel Hill, Chapel Hill, NC, USA; Department of Biomedical Engineering, University of North Carolina Chapel Hill, Chapel Hill, NC, USA; Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA; Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA, USA
- Hsian-Rong Tseng Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, USA
- Jonathan W. Uhr Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
- John A. Viator Biomedical Engineering Program, Duquesne University, Pittsburgh, PA, USA
- Jose Varillas J. Crayton Pruitt...
