
Advances in Cancer Research
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Content
- Front Cover
- Advances in Cancer Research
- Copyright Page
- Contents
- Contributors to Volume 90
- Chapter 1. Microenvironmental Regulation of the Initiated Cell
- I. Introduction
- II. Initiation and Promotion of Tumor Development in the Skin of Animals Painted with Carcinogens
- III. Inhibition of Initiated Keratinocytes in Culture by Normal Keratinocytes
- IV. Inhibition of Neoplastic Progression in Mice or in Organotypic Culture by Normal Keratinocytes
- V. Inhibition of Virally Transformed Malignant Keratinocytes by Dermal Fibroblasts in Skin Grafts and in Subcutaneous Injections
- VI. Restriction of Mutant Keratinocytes to the Epidermal Proliferative Unit in Ultraviolet (UV) Carcinogenesis of the Skin
- VII. Microenvironmental Suppression of Neoplastic Transformation Among Cultured Fibroblasts
- VIII. Evaluation of the Evidence Concerning a Role for Proteases in Tumor Initiation
- IX. Visualization of Microenvironmental Regulation in Spontaneous Transformation of Mouse Fibroblasts
- X. Microenvironmental Effects on Mammary Neoplasia
- XI. Further Developments on the Role of Proteases in Carcinogenesis
- XII. Conclusions
- References
- Chapter 2. Persistent Infection with Helicobacter Pylori and the Development of Gastric Cancer
- I. Introduction-H. Pylori and Cancer Development
- II. Bacterial Colonization and Persistence
- III. H. Pylori-Mediated Mucosal Inflammation
- IV. Effects of H. Pylori Infection on Epithelial Cell Turnover
- V. H. Pylori-Mediated Promotion of Tumor Development
- VI. Host Susceptibility Genes and Gastric Cancer Associated with H. Pylori Infection
- VII. Concluding Remarks
- References
- Chapter 3. High-Resolution Analysis of Genetic Events in Cancer Cells Using Bacterial Artificial Chromosome Arrays and Comparative Genome Hybridization
- I. Introduction
- II. Evolution of Molecular Cytogenetics
- III. Development of BAC Resources
- IV. CGHa in the Analysis of Cancer
- V. Summary
- References
- Chapter 4. Natural Killer Cells and Cancer
- I. Introduction
- II. NK Cell Biology
- III. NK Cell Effector Functions
- IV. Receptors Turning NK Cells ''On'' and ''Off''
- V. NK Cells in Tumor Immunosurveillance
- VI. Tumor Escape Mechanisms
- VII. Conclusion
- References
- Chapter 5. Immunity to Cancer Through Immune Recognition of Altered Self: Studies with Melanoma
- I. Introduction
- II. Melanoma Antigens
- III. Cellular Responses to Differentiation Antigens
- IV. Antibody-Mediated Tumor Immunity and Autoimmunity
- V. Clinical Applications
- References
- Chapter 6. Chemical Carcinogens as Foreign Bodies and Some Pitfalls Regarding Cancer Immune Surveillance
- I. Introduction
- II. Chemical Carcinogenesis
- III. Increased Tumor Incidence by MCA in IFNyR-KO Compared with IFNyR-WT Mice
- IV. No New Evidence that Supports T-Cell-Mediated Immune Surveillance of MCA-Induced or Spontaneous Tumors
- V. The Protective Response in IFNyR-WT Mice is Associated with Encapsuation of MCA
- VI. Concluding Remarks
- References
- Chapter 7. Epigenetic Theories of Cancer Initiation
- I. Introduction
- II. Evidence that the Early Stages of Cancer are Epigenetic
- III. Mechanisms of Epigenesis
- IV. Concluding Remarks
- References
- Index
- Color Plate Section
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