NMR in Pharmaceutical Science
Published on 24. August 2015
504 pages
978-1-118-66023-2 (ISBN)
Description
NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists.
This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies.
Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes.
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More details
Other editions
Additional editions
Jeremy R. Everett | Robin K. Harris | John C. Lindon
NMR in Pharmaceutical Science
Book
09/2015
1st Edition
Wiley
€133.50
Article not available at the moment
Persons
Editors
Jeremy R. Everett, University of Greenwich, Kent, UK
Robin K. Harris, University of Durham, Durham, UK
John C. Lindon, Imperial College London, UK
Ian D. Wilson, Imperial College London, UK
Content
1 Drug Discovery and Development: The Role of NMR
2 Modern NMR Pulse Sequences in Pharmaceutical R & D
3 Experimental NMR Methods for Pharmaceutical Research and Development
4 19F NMR spectroscopy: applications in pharmaceutical studies
5 Quantitative NMR Spectroscopy in Pharmaceutical R & D
6 High-throughput NMR in Pharmaceutical R & D
7 Multivariate Data Analysis methods for Pharmaceutical NMR
8 The Role of NMR in Target Identification & Validation for Pharmaceutical R & D
9 High Resolution MAS NMR of Tissues and Cells
10 NMR Studies of Inborn Errors of Metabolism.
11 NMR-Based Structure Confirmation of Hits & Leads in Pharmaceutical R & D
12 Fragment-based drug design using NMR methods
13 Hit Discovery from Natural Products in Pharmaceutical R & D
14 NMR-Based Structure Determination of Drug Leads and Candidates
15 Mixture Analysis in Pharmaceutical R & D using Hyphenated NMR Techniques
16 Conformation and Stereochemical Analysis of Drug Molecules
17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds
18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety
19 Pre-clinical Drug Metabolism using NMR
20 Pre-clinical Drug Efficacy and Safety using NMR Spectroscopy
21 Characterization of Pharmaceutical Compounds by Solid-State NMR
22 Structure-based Drug Design using NMR
23 Pharmaceutical Technology Studied by MRI
24 NMR-Based Metabolic Phenotyping for Disease Diagnosis & Stratification
25 NMR-Based Pharmacometabonomics: A New Approach to Personalised Medicine
26 Clinical MRI Studies of Drug Efficacy & Safety
27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&D
28 Analysis of counterfeit medicines and adulterated dietary supplements by NMR
29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy
30 NMR Spectroscopy in the European & US Pharmacopoeias
31 NMR in Pharmaceutical Manufacturing
Thomas M. Bocan US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA
The Geneva Foundation, 917 Pacific Ave, Suite 600, Tacoma, WA 98402, USA
Chapter 18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety Sarah K. Branch Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK
Chapter 29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy
Chapter 30 NMR Spectroscopy in the European and US Pharmacopeias Stephen J. Byard Covance Laboratories, Alnwick, UK
Chapter 23 Pharmaceutical Technology Studied by MRI Leo L. Cheng Massachusetts General Hospital, Harvard Medical School, Pathology, MGH 149, 13th Street Charlestown, Boston, MA 02129, USA
Chapter 9 High-resolution MAS NMR of Tissues and Cells Muireann Coen Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
Chapter 20 Preclinical Drug Efficacy and Safety Using NMR Spectroscopy Olivia Corcoran Medicines Research Group, School of Health, Sport and Bioscience, University of East London, London E15 4LZ, UK
Chapter 13 Hit Discovery from Natural Products in Pharmaceutical R&D Helen Corns Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK
Chapter 30 NMR Spectroscopy in the European and US Pharmacopeias Paulo Dani Former employee from Merck Sharp & Dohme (MSD), Oss, The Netherlands
Chapter 31 NMR in Pharmaceutical Manufacturing Anthony C. Dona MRC-NIHR National Phenome Centre, Department of Surgery & Cancer, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Chapter 3 Experimental NMR Methods for Pharmaceutical Research and Development Jeremy R. Everett Medway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UK
Chapter 1 Drug Discovery and Development: The Role of NMR
Chapter 25 NMR-based Pharmacometabonomics: A New Approach to Personalized Medicine Paul D. Hockings Antaros Medical, BioVenture Hub, 43183 Mölndal, Sweden
Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety John C. Hollerton GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK
Chapter 6 High-throughput NMR in Pharmaceutical R&D Ulrike Holzgrabe Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany
Chapter 5 Quantitative NMR Spectroscopy in Pharmaceutical R&D Mark Jeeves School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK
Chapter 22 Structure-based Drug Design Using NMR Beatriz Jiménez Clinical Phenotyping Centre, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK
Chapter 24 NMR-based Metabolic Phenotyping for Disease Diagnosis and Stratification Lauren Keith National Institute of Allergy and Infectious Disease, 8200 Research Plaza, Frederick, MD 21702, USA
Chapter 18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety Edwin Kellenbach Aspen Pharmacare, PO Box 20, 5340BH Oss, Oss, The Netherlands
Chapter 31 NMR in Pharmaceutical Manufacturing Sarantos Kostidis Center for Proteomics and Metabolomics, Leiden University Medical Center, P.O. Box 9600, 2300RC Leiden, The Netherlands
Chapter 10 NMR Studies of Inborn Errors of Metabolism John C. Lindon Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
Chapter 4 19F NMR Spectroscopy: Applications in Pharmaceutical Studies
Chapter 15 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR Techniques Myriam Malet-Martino Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France
Chapter 28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR Robert Martino Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France
Chapter 28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR James S. McKenzie Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
Chapter 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research Emmanuel Mikros Faculty of Pharmacy, University of Athens Panepistimiopolis, 15771 Zografou, Greece
Chapter 10 NMR Studies of Inborn Errors of Metabolism Jeremy K. Nicholson Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
Chapter 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research Michael Overduin School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK
Chapter 22 Structure-based Drug Design Using NMR John A. Parkinson WestCHEM, Department of Pure and Applied Chemistry, NMR Spectroscopy Facility, University of Strathclyde, Glasgow G1 1XL, UK
Chapter 2 Modern NMR Pulse Sequences in Pharmaceutical R&D Torren M. Peakman torren@nmrpeak.co.uk
Chapter 14 NMR-based Structure Determination of Drug Leads and Candidates Antonio Pineda-Lucena Structural Biochemistry Laboratory, Advanced Therapies Program, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012-Valencia, Spain
Chapter 12 Fragment-based Drug Design Using NMR Methods Leonor Puchades-Carrasco Structural Biochemistry Laboratory, Advanced Therapies Program, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012-Valencia, Spain
Chapter 12 Fragment-based Drug Design Using NMR Methods Lee Quill School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK
Chapter 22 Structure-based Drug Design Using NMR David G. Reid Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Chapter 23 Pharmaceutical Technology Studied by MRI
Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety Ricardo Riguera Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
Chapter 17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds Andrea Ruggiero Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK
Chapter 29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy Nadeem Saeed BioClinica, 72 Hammersmith Road, London W14 8UD, UK
Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety Krishna Saxena Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, D-60438, Germany
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Chapter 8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&D Harald Schwalbe Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance,...
Contributors
Thomas M. Bocan US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA
The Geneva Foundation, 917 Pacific Ave, Suite 600, Tacoma, WA 98402, USA
Chapter 18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety Sarah K. Branch Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK
Chapter 29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy
Chapter 30 NMR Spectroscopy in the European and US Pharmacopeias Stephen J. Byard Covance Laboratories, Alnwick, UK
Chapter 23 Pharmaceutical Technology Studied by MRI Leo L. Cheng Massachusetts General Hospital, Harvard Medical School, Pathology, MGH 149, 13th Street Charlestown, Boston, MA 02129, USA
Chapter 9 High-resolution MAS NMR of Tissues and Cells Muireann Coen Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
Chapter 20 Preclinical Drug Efficacy and Safety Using NMR Spectroscopy Olivia Corcoran Medicines Research Group, School of Health, Sport and Bioscience, University of East London, London E15 4LZ, UK
Chapter 13 Hit Discovery from Natural Products in Pharmaceutical R&D Helen Corns Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK
Chapter 30 NMR Spectroscopy in the European and US Pharmacopeias Paulo Dani Former employee from Merck Sharp & Dohme (MSD), Oss, The Netherlands
Chapter 31 NMR in Pharmaceutical Manufacturing Anthony C. Dona MRC-NIHR National Phenome Centre, Department of Surgery & Cancer, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Chapter 3 Experimental NMR Methods for Pharmaceutical Research and Development Jeremy R. Everett Medway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UK
Chapter 1 Drug Discovery and Development: The Role of NMR
Chapter 25 NMR-based Pharmacometabonomics: A New Approach to Personalized Medicine Paul D. Hockings Antaros Medical, BioVenture Hub, 43183 Mölndal, Sweden
Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety John C. Hollerton GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK
Chapter 6 High-throughput NMR in Pharmaceutical R&D Ulrike Holzgrabe Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany
Chapter 5 Quantitative NMR Spectroscopy in Pharmaceutical R&D Mark Jeeves School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK
Chapter 22 Structure-based Drug Design Using NMR Beatriz Jiménez Clinical Phenotyping Centre, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK
Chapter 24 NMR-based Metabolic Phenotyping for Disease Diagnosis and Stratification Lauren Keith National Institute of Allergy and Infectious Disease, 8200 Research Plaza, Frederick, MD 21702, USA
Chapter 18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety Edwin Kellenbach Aspen Pharmacare, PO Box 20, 5340BH Oss, Oss, The Netherlands
Chapter 31 NMR in Pharmaceutical Manufacturing Sarantos Kostidis Center for Proteomics and Metabolomics, Leiden University Medical Center, P.O. Box 9600, 2300RC Leiden, The Netherlands
Chapter 10 NMR Studies of Inborn Errors of Metabolism John C. Lindon Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
Chapter 4 19F NMR Spectroscopy: Applications in Pharmaceutical Studies
Chapter 15 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR Techniques Myriam Malet-Martino Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France
Chapter 28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR Robert Martino Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France
Chapter 28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR James S. McKenzie Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
Chapter 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research Emmanuel Mikros Faculty of Pharmacy, University of Athens Panepistimiopolis, 15771 Zografou, Greece
Chapter 10 NMR Studies of Inborn Errors of Metabolism Jeremy K. Nicholson Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
Chapter 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research Michael Overduin School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK
Chapter 22 Structure-based Drug Design Using NMR John A. Parkinson WestCHEM, Department of Pure and Applied Chemistry, NMR Spectroscopy Facility, University of Strathclyde, Glasgow G1 1XL, UK
Chapter 2 Modern NMR Pulse Sequences in Pharmaceutical R&D Torren M. Peakman torren@nmrpeak.co.uk
Chapter 14 NMR-based Structure Determination of Drug Leads and Candidates Antonio Pineda-Lucena Structural Biochemistry Laboratory, Advanced Therapies Program, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012-Valencia, Spain
Chapter 12 Fragment-based Drug Design Using NMR Methods Leonor Puchades-Carrasco Structural Biochemistry Laboratory, Advanced Therapies Program, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012-Valencia, Spain
Chapter 12 Fragment-based Drug Design Using NMR Methods Lee Quill School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK
Chapter 22 Structure-based Drug Design Using NMR David G. Reid Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Chapter 23 Pharmaceutical Technology Studied by MRI
Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety Ricardo Riguera Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
Chapter 17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds Andrea Ruggiero Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK
Chapter 29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy Nadeem Saeed BioClinica, 72 Hammersmith Road, London W14 8UD, UK
Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety Krishna Saxena Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, D-60438, Germany
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Chapter 8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&D Harald Schwalbe Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance,...
