The Enzymes
Academic Press
3rd Edition
Published on 19. March 1987
509 pages
978-0-08-086595-9 (ISBN)
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The Enzymes
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Paul D. Boyer | Edwin G. Krebs
Enzymes: v. 18
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03/1987
3rd Edition
Academic Press
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Ross Dalbey | Carla Koehler | Fuyuhiko Tamanoi
The Enzymes
Molecular Machines Involved in Protein Transport across Cellular Membranes
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Content
- Front Cover
- The Enzymes: Control by Phosphorylation
- Copyright Page
- Contents
- Preface
- Section I: Control of Specific Enzymes (Continued)
- Chapter 1. Enzymes of the Fructose 6-Phosphate-Fructose 1,6-Bisphosphate Substrate Cycle
- I. Introduction
- II. Purification of Hepatic 6-Phosphofructo-2-Kinase- Fructose-2,6-Bisphosphatase
- III. Assay of 6-Phosphofructo-2-Kinase Activity
- IV. Assay of Fructose-2,6-Bisphosphatase Activity
- V. Structural Properties
- VI. Catalytic Properties of Rat Liver 6-Phosphofructo-2-Kinase
- VII. Catalytic Properties of Rat Liver Fructose-2,6- Bisphosphatase
- VIII. Evidence for Two Catalytic Centers
- IX. Regulation of 6-Phosphofructo-2-Kinase- Fructose-2,6-Bisphophatase by Low-Molecular-Weight Effectors
- X. Regulation of 6-Phosphofructo-2-Kinase-Fructose-2,6- Bisphosphatase by Phosphorylation-Dephosphorylation
- XI. 6-Phosphofructo-1 -Kinase: Possible Role of Phosphorylation in the Control of Enzyme Activity
- XII. Fructose-l,6-Bisphosphatase: Possible Role of Phosphorylation in Control of Enzyme Activity
- XIII. Role of 6-Phosphofructo-2-Kinase-Fructose-2,6- Bisphosphatase in the Hormonal Control of Hepatic Gluconeogenesis and Glycolysis
- XIV. Summary and Overview
- References
- Chapter 2. Pyruvate Kinase
- I. Introduction
- II. Influence of Phosphorylation on the Kinetic Properties of Liver Pyruvate Kinase
- III. Influence of Phosphorylation on the Sensitivity of Liver Pyruvate Kinase to Proteolytic Enzymes
- IV. The Reaction of Cyclic AMP-Dependent Protein Kinase with Liver Pyruvate Kinase as Substrate
- V. Dephosphorylation of Liver Pyruvate Kinase with Phosphoprotein Phosphatases
- VI. Acute Hormonal Regulation of Liver Pyruvate Kinase in Vivo and in Intact Cells
- VII. Phosphorylation of Other Pyruvate Kinases
- VIII. Concluding Remarks
- References
- Chapter 3. Pyruvate Dehydrogenase
- I. Introduction
- II. Mammalian Pyruvate Dehydrogenase Complex
- III. Pyruvate Dehydrogenase Kinase
- IV. Pyruvate Dehydrogenase Phosphatase
- V. Regulation of Mammalian Pyruvate Dehydrogenase Complex
- VI. Comparison of Properties of Mitochondrial a-Ketoacid Dehydrogenase Kinases and Phosphatases
- References
- Chapter 4. Branched-Chain Ketoacid Dehydrogenase
- I. Introduction
- II. Animal Branched-Chain Ketoacid-Dehydrogenase Complex
- III. Regulation by Reversible Phosphorylation
- IV. Biological Significance of Reversible Phosphorylation
- V. Addendum
- References
- Chapter 5. Acetyl-Coenzyme A Carboxylase
- I. Introduction
- II. Structural Aspects and Regulation by Allosteric Effectors
- III. Short-Term Hormonal Regulation of Fatty Acid Synthesis Associated with Persistent Changes in Acetyl-CoA Carboxylase Activity
- IV. Early Evidence for the Regulation of Acetyl-CoA Carboxylase by Reversible Phosphorylation
- V. Effects of Hormones on the level of Phosphorylation of Acetyl-CoA Carboxylase within Intact Cell Preparations
- VI. Protein Kinases That Phosphorylate Acetyl -CoA Carboxylase
- VII. Protein Phosphatases That Act on Acetyl-CoA Carboxylase
- VIII. Concluding Remarks
- References
- Chapter 6. Hormone-Sensitive Lipase
- I. Introduction
- II. Properties
- II. Mechanism of Regulation of the Adipose Tissue Lipase
- IV. Possible Role as a Hormone-Activatable, Multifunctional Tissue Lipase
- V. Conclusions and Perspectives
- References
- Chapter 7. Hydroxymethylglutaryl- Coenzyme A Reductase
- I. Introduction
- II. Topology
- III. Multivalent Control
- IV. Reversible Phosphorylation in Vitro
- V. lntracellular Phosphorylation
- VI. Reversible Phosphorylation and Degradation
- References
- Chapter 8. Aromatic Amino Acid Hydroxylases
- I. Introduction
- II. Phenylalanine Hydroxylase
- III. Tyrosine Hydroxylase
- IV. Tryptophan Hydroxylase
- References
- Section II: Control of Biological Processes
- Chapter 9. Phosphorylation of Bra in Proteins
- I. Introduction
- II. Protein Kinases in the Brain
- III. Phosphoproteins in the Brain
- IV. Protein Phosphatases in the Brain
- V. Conclusion
- References
- Chapter 10. Regulation of Receptor Function
- I. Introduction and Perspectives
- II. The ß-Adrenergic Receptor
- III. Rhodopsin
- IV. The Nicotinic Acetylcholine Receptor
- V. The Receptors for EGF and Insulin
- VI. Other Membrane Receptors
- References
- Chapter 11. Regulation of Ionic Channels
- I. Introduction
- II. Calcium Channels
- III. Potassium Channels
- IV. Acetylcholine Receptor
- V. Sodium Channels
- VI. Conclusions
- References
- Chapter 12. Regulation of Protein Synthesis
- I. Introduction
- II. Initiation of Protein Synthesis in Eukaryotic Cells
- III. Role of elF-2 in Eukaryotic Protein Chain Initiation and the Effect of elF-2a Phosphorylation
- IV. Heme-Regulated elF-2a Kinase
- V. dsRNA-Dependent elF-2a Kinase
- VI. Biological Significance of HRI and dsl
- VII. Guanine Nucleotide-Binding Proteins
- References
- Chapter 13. Regulation of Contractile Activity
- I. Introduction
- II. Regulation of Vertebrate Smooth-Muscle Myosin by Phosphorylation
- III. Role of Phosphorylation in Modulating Contractile Activity of Striated Muscle Proteins
- IV. Phosphorylation-Dependent Regulatory Systems in Invertebrate Muscles
- VI. Summary
- References
- Chapter 14. Protein Phosphorylation in Prokaryotes and Single-Celled Eukaryotes
- I. Introduction
- II. Protein Phosphorylation in Prokaryotes
- III. Protein Phosphorylation in Single-Celled Eukaryotes
- IV. General Comments
- References
- Author Index
- Subject Index
