The Enzymes
Academic Press
3rd Edition
Published on 22. October 1986
609 pages
978-0-08-086594-2 (ISBN)
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The Enzymes
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Paul D. Boyer | Edwin G. Krebs
Enzymes: v. 17
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10/1986
3rd Edition
Academic Press
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Ross Dalbey | Carla Koehler | Fuyuhiko Tamanoi
The Enzymes
Molecular Machines Involved in Protein Transport across Cellular Membranes
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Content
- Front Cover
- The Enzymes, Volume XVII
- Copyright Page
- Contents
- Preface
- Section I. Enzymology of Control by Phosphorylation
- Chapter 1. The Enzymology of Control by Phosphorylation
- I. Historical Aspects of Protein Phosphorylation
- II. Protein Phosphorylation-Dephosphorylation Reactions
- III. Classification of Protein Kinases and Phosphoprotein Phosphatases
- IV. Protein Phosphorylation and the Regulation of Biological Processes
- References
- Chapter 2. Cyclic Cascades and Metabolic Regulation
- I. Perspectives
- II. Features of Cyclic Cascade Systems
- III. Experimental Verification of the Cyclic Cascade Model
- IV. Energy Consumption
- V. Covalent Interconversion versus Simple Allosteric Control
- VI. Concluding Remarks
- References
- Chapter 3. Cyclic Nucleotide-Dependent Protein Kinases
- I. Introduction
- II. Purification
- III. Characterization and Physical Properties
- IV. Mechanism of Action
- V. Biological Role of Protein Kinases
- References
- Chapter 4. Calmodulin-Dependent Protein Kinases
- I. Introduction
- II. Myosin Light Chain Kinases
- III. Multifunctional Calmodulin-Dependent Protein Kinases
- References
- Chapter 5. Protein Kinase C
- I. Introduction
- II. Properties
- III. Biochemical Activation
- IV. Physiological Activation
- V. Action of Tumor Promoters
- VI. Inhibitors
- VII. Synergistic Roles with Calcium
- VIII. Growth Response and Down Regulation
- IX. Target Proteins and Catalytic Specificity
- X. Relation to Other Receptors
- XI. Conclusion
- References
- Chapter 6. Viral Oncogenes and Tyrosine Phosphorylation
- I. Introduction and Historical Perspective
- II. Individual Viral Protein-Tyrosine Kinases and Their Cellular Homologues
- III. Other Transformation-Related Tyrosine Phosphorylation Systems
- IV. General Properties of Protein-Tyrosine Kinases
- V. Cellular Substrates for Protein-Tyrosine Kinases
- VI. Conclusions
- References
- Chapter 7. The Insulin Receptor and Tyrosine Phosphorylation
- I. Introduction and Scope
- II. Structure of the Insulin Receptor and Its Relation to Other Tyrosine-Specific Protein Kinases
- III. Properties of Tyrosine-Specific Protein Kinases
- IV. Tyrosine Phosphorylation of Insulin Receptors and Other Proteins in the Intact Cell
- V. Regulation of Hormone Receptors by Multisite Phosphorylation
- VI. Evidence That Tyrosine Phosphorylation Is Physiologically Important
- VII. Conclusions
- References
- Chapter 8. Phosphoprotein Phosphatases
- I. Introduction and Historical Overview: The "PR Enzyme
- II. Classification of Protein Phosphatases
- III. Phosphatase Type 1 (Phosphorylase Phosphatase)
- IV. Phosphatase Type 2A
- V. Phosphatase Type 2B (Calcineurin)
- VI. Phosphatase Type 2C
- VII. Phosphotyrosyl-Protein Phosphatases
- References
- Section II. Control of Specific Enzymes
- Chapter 9. Glycogen Phosphorylase
- I. Introduction
- II. Enzymic Characteristics of Phosphorylase
- III. Molecular Structure
- IV. Substrate-Directed Control of Phosphorylation and Dephosphorylation
- V. Structural Consequences of Serine-14 Phosphorylation
- VI. Functional Results of the Phosphorylation of Serine-14
- VII. Concluding Remarks
- References
- Chapter 10. Phosphorylase Kinase
- I. Introduction
- II. Physicochemical Properties
- III. Subunit Function and Interaction between Subunits
- IV. Catalytic Properties
- V. Regulation of Phosphorylase Kinase Activity by Allosteric Effectors
- VI. Proteolytic Activation of Phosphorylase Kinase
- VII. Covalent Regulation: In Vitro Studies
- VIII. Regulation of Phosphorylase Kinase in Intact Cells
- References
- Chapter 11. Muscle Glycogen Synthase
- I. Introduction
- II. Structure of Glycogen Synthase from Mammalian Skeletal Muscle
- III. Glycogen Synthase Kinases in Mammalian Skeletal Muscle
- IV. Effect of Phosphorylation on the Activity of Skeletal-Muscle Glycogen Synthase
- V. Synergism between Glycogen Synthase Kinase-3 and Glycogen Synthase Kinase-5
- VI. The Glycogen Synthase Phosphatases in Skeletal Muscle
- VII. Phosphorylation State of Skeletal-Muscle Glycogen Synthase in Vivo
- VIII. Interpretation of in Vivo Phosphorylation Experiments
- References
- Chapter 12. Liver Glycogen Synthase
- I. Introduction
- II. Liver Glycogen Synthase
- III. Converting Enzymes
- IV. Phosphorylation of Liver Glycogen Synthase
- V. Comparative Enzymology of Glycogen Synthase
- VI. Control of Hepatic Glycogen Synthase
- VII. Conclusion
- References
- Author Index
- Subject Index
